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Revolutionary IVF Study May Change the Way Embryos are Biopsied for Genetic Disease
Date:10/19/2011

5 biopsy.  For both groups, physicians transferred one biopsied and one non-biopsied embryo into participants. With those that resulted in singleton (one baby) pregnancies, DNA fingerprinting was conducted to determine whether the baby resulted from the biopsied or non-biopsied embryo.

"We found a loss of reproductive potential by more than one third when comparing embryos biopsied on day 3 versus non-biopsied embryos, 31% versus 53%," said Dr. Scott.  "These results suggest that day 3 biopsy dramatically decreases an embryo's chances of becoming a healthy baby.  In contrast, the implantation rate of biopsied and non-biopsied day 5 embryos was equivalent, 52% versus 54%.  This study demonstrated that day 5 blastocyst biopsy is unequivocally safer than day 3 cleavage stage biopsy, and does not diminish the potential for embryos to implant and develop into healthy babies," Dr. Scott explained.  

Previous groundbreaking research at RMANJ into its Comprehensive Chromosome Screening technique demonstrated that when chromosomally normal embryos are identified prior to embryo transfer, it increases a couple's chance of conception.  "We now know that the safest method is to culture the embryos to the blastocyst stage and biopsy at day 5," Dr. Scott explained. "The chromosomal screening technique we developed is unique in that we can obtain results of genetic analysis in as little as four hours, allowing day 5 biopsy and embryo transfer in one cycle.  The combination of culture to day 5, safe embryo biopsy, and utilization of a highly validated and rapid genetic technology dramatically improves delivery rates," said Dr. Scott.  

Conducting embryo biopsy on day 5 is much more highly advanced than the day 3 biopsies.  "To conduct day 5 blastocyst biopsies with positive results, the embryologists must be skilled and experienced in this method," Dr. Scott continued.  "This technology, the only technology of
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SOURCE Reproductive Medicine Associates of New Jersey
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