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Revised: Othera Pharmaceuticals Appoints Dr. Frederick R. Rickles Chief Scientific Officer
Date:10/2/2007

-730 as a novel improved beta-blocker for treatment of glaucoma. OT-730 is designed to have excellent beta-blocking activity in the eye, yet easily break down into inert components upon entry into the bloodstream. Today's marketed beta-blockers as a class are the most widely-prescribed drugs by volume for glaucoma, but suffer from the potential danger of systemic side effects. Initial preclinical studies support the concept that OT-730 could overcome the systemic side effect problem. An IND filing is planned for 2008.

Othera's product pipeline also includes orally-acting, small molecule analogues of OT-551. OT-304 has been identified as the lead candidate in this series and has demonstrated activity in preclinical models of cell-mediated thrombosis in cancer and inflammatory diseases. Completion of preclinical development supporting the use of OT-304 in the treatment and/or prevention of thrombosis in cancer and inflammatory diseases is expected later this year. The appointment of Dr. Rickles as CSO will enhance Othera's existing development capabilities and expertise as he is one of the most recognized experts in cancer and thrombosis in the world.

For information please visit Othera's website at http://www.othera.com.


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SOURCE Othera Pharmaceuticals, Inc.
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