Navigation Links
Reverse engineering epilepsy's 'miracle' diet
Date:5/25/2012

For decades, neurologists have known that a diet high in fat and extremely low in carbohydrates can reduce epileptic seizures that resist drug therapy. But how the diet worked, and why, was a mysteryso much so that in 2010, The New York Times Magazine called it "Epilepsy's Big, Fat Miracle."

Now, researchers at Dana-Farber Cancer Institute and Harvard Medical School have proposed an answer, linking resistance to seizures to a protein that modifies cellular metabolism in the brain. The research, to be published in the May 24th issue of the journal Neuron, may lead to the development of new treatments for epilepsy.

The research was led jointly by Nika Danial, HMS assistant professor of cell biology at Dana-Farber Cancer Institute, and Gary Yellen, professor of neurobiology at Harvard Medical School. The first author was Alfredo Gimnez-Cassina, a research fellow in Danial's lab.

Epilepsy is a neurological disorder characterized by repeated seizures, an electrical storm in the brain that can manifest as convulsions, loss of motor control, or loss of consciousness. Some cases of epilepsy can be improved by a diet that drastically reduces sugar intake, triggering neurons to switch from their customary fuel of glucose to fat byproducts called ketone bodies. The so-called ketogenic diet, which mimics effects of starvation, was described more than 80 years ago and received renewed interest in the 1990s. Recent studies corroborate that it works, but shed little light on how.

"The connection between metabolism and epilepsy has been such a puzzle," said Yellen, who was introduced to the ketogenic diet through his wife, Elizabeth Thiele, HMS professor of neurology, who directs the Pediatric Epilepsy Program at MassGeneral Hospital for Children, but was not directly involved in the study. "I've met a lot of kids whose lives are completely changed by this diet," Yellen said. "It's amazingly effective, and it works for many kids for
'/>"/>

Contact: David Cameron
david_cameron@hms.harvard.edu
617-432-0441
Harvard Medical School
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Groundbreaking National Program to Reverse Obesity Expands to 50 Locations
2. Soligenix Announces 1 for 20 Reverse-Split of its Common Stock
3. Stem cell therapy reverses diabetes
4. Rosetta Genomics Announces One-For-Four Reverse Stock Split
5. Reverse NanoJapan: Rice to host 25-30 Japanese students
6. Cord Blood America Announces Reverse Stock Split Takes Effect Monday, May 9, 2011
7. Spherix Announces Reverse Stock Split Effective May 6, 2011
8. Cord Blood America: Shareholders Approve Common Stock Reverse Split
9. Spherix to Effect Reverse Stock Split
10. GenVec, Inc. Announces Effectiveness of Reverse Stock Split
11. Advanced Life Sciences Announces 2010 Fourth Quarter and Full Year Financial Results and Reverse Stock Split
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2015)... -- Research and Markets ( ... PharmaBiotech,s new report "Biomarkers - Technologies, Markets ... This report follows the broad definition of a ... measured and evaluated as an indicator of normal ... responses to a therapeutic intervention. Tests based on ...
(Date:9/2/2015)... (PRWEB) , ... September 02, 2015 , ... ... development of botanical and plant-derived compounds. BCC Research reveals in its new ... 2020 because this market defines the category and generates the most market demand. ...
(Date:9/2/2015)... Sept. 2, 2015 Veracyte, Inc. (NASDAQ: ... , president and chief executive officer, will present at ... 16, 2015 at 10:30 a.m. ET in ... live audio webcast and subsequent replay may be accessed ... be available shortly after conclusion of the presentation and ...
(Date:9/2/2015)... (PRWEB) , ... September 02, 2015 , ... ... critical demand to aid high-risk surgeries. From vital sign monitoring in ICU to ... Intel technology enables surgeon to make real-time clinical decisions with simultaneous access to ...
Breaking Biology Technology:Updated 2015 Biomarkers Report - Latest Technologies, Markets and Companies Insights to 2024 with over 1,000 References 2Updated 2015 Biomarkers Report - Latest Technologies, Markets and Companies Insights to 2024 with over 1,000 References 3Plant-derived Compounds Poised to Assume Greater Role in Global Drug Markets, According to BCC Research 2Plant-derived Compounds Poised to Assume Greater Role in Global Drug Markets, According to BCC Research 3Veracyte to Present at Morgan Stanley Global Healthcare Conference 2Surgical Workstation Powered by 6th Gen. Intel® Core™ Skylake Processors 2Surgical Workstation Powered by 6th Gen. Intel® Core™ Skylake Processors 3
...  Dyadic International, Inc. ("Dyadic") (OTC Pink: DYAI), a global ... sale of enzyme and protein products for the industrial ... will launch FibreZyme® G5000, a next generation, ... to improve paper quality and improve the economics of ...
... awareness about the disease and its overall occurrence and ... (MS) market. This is being exacerbated by the limited ... immediate need for innovative and enhanced therapeutic and diagnostic ... of treatment options. New analysis from Frost ...
... 2012   Kimberly-Clark Corporation (NYSE: KMB ... vice president of Global Nonwovens, has been named to ... in Corporate America." The Top 100 listing showcases ... and executives representing a diverse range of industries who ...
Cached Biology Technology:Dyadic International Launches FibreZyme® G5000 High Performance Powder Pulp and Paper Enzyme in Booth #1065 at Tissue World Americas Conference 2Dyadic International Launches FibreZyme® G5000 High Performance Powder Pulp and Paper Enzyme in Booth #1065 at Tissue World Americas Conference 3European Multiple Sclerosis Market in Dire Need of Increased Disease Awareness and Treatment Options, Cautions Frost & Sullivan 2European Multiple Sclerosis Market in Dire Need of Increased Disease Awareness and Treatment Options, Cautions Frost & Sullivan 3Kimberly-Clark's Bob Stargel Named One of Savoy Magazine's Top 100 Most Influential Blacks in Corporate America 2Kimberly-Clark's Bob Stargel Named One of Savoy Magazine's Top 100 Most Influential Blacks in Corporate America 3
(Date:8/6/2015)... and TELTOW, Germany , August ... Siggraph Conference, SensoMotoric Instruments (SMI) shows the ... , based on Epson,s Moverio BT-200 see-through ... platform. With this new solution, unprecedented quality and efficiency ... interaction with context-sensitive displays. For the first time, professionals ...
(Date:8/5/2015)... Calif. , Aug. 5, 2015 The ... continuous growth in applications, penetration into newer sectors, and ... year. The global biosensors space has seen the entry ... the market so far. (Photo - ... & Sullivan, Analysis of the Global Biosensors Market ...
(Date:7/31/2015)... Kina, 31. juli 2015 Den 10. internationale ... af BGI fra den 22. - 25. oktober i ... fejrer sin 10-års fødselsdag i år. Siden starten i ... årlige møder på ,omik,-feltet, og er en af de ... ICG-10 fokuserer på nylige gennembrud og fremskridt inden ...
Breaking Biology News(10 mins):SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 2SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 3Innovative Biosensors Incite Use in Non-Traditional Applications 2Innovative Biosensors Incite Use in Non-Traditional Applications 3Innovative Biosensors Incite Use in Non-Traditional Applications 4Den 10. internationale konference om Genomics (ICG-10) åbner i oktober 2
... (Rockville, MD September 20, 2007) Fifteen students mentored ... (ASPB) were selected to receive the 2007ASPB Summer Undergraduate ... to devote full-time effort to his or her research ... award also includes $500 to the mentor for lab ...
... West Nile virus first struck New York City in ... and public health officials alike, showing that even affluent, ... Nile virus has been widely studied, there is still ... differs between urban and rural areas. Assistant professor ...
... anniversaries of Annals of the Entomological Society of America ... oldest journals. The occasion will be celebrated at ESAs ... over 2,000 entomologists will gather for four days of ... were launched the same year (1908), but with very ...
Cached Biology News:ASPB announces Summer Undergraduate Research Fellowship 2007 recipients 2ASPB announces Summer Undergraduate Research Fellowship 2007 recipients 3UGA Odum School of Ecology professor receives grant to study West Nile Virus in NYC 2ESA celebrates 100 years of insect science journals 2
Glutamate Receptor 5/1a...
Dual Color Mouse anti-Human Anti-Kappa FITC/CD19 PE Class: Antibody Product Group: Immunogluobulin...
... monoclonal [EP282Y] to Asparagine synthetase ... tested applications). ... to residues in the C-terminus ... Entrez GeneID: ...
Fluorescein isothiocyanate (FITC) mouse anti-human IFN-alpha2 50 ug...
Biology Products: