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Resverlogix Phase 1b/2a Study Meets Primary Endpoint
Date:8/25/2009

    TSX Exchange Symbol: RVX

    Additional quarterly and clinical updates included

CALGARY, Aug. 25 /PRNewswire-FirstCall/ - Resverlogix Corp. (TSX:RVX) is pleased to announce several quarterly updates. The Phase 1b/2a study testing RVX-208 for 28 days in three different doses has met its primary endpoint of increasing plasma ApoA-I significantly. Quality controls are still ongoing as part of regular good clinical practice, thus the compilation of the full data report should take place within the second half of 2009. As such if there are modifications to this endpoint they will be communicated. This successful data, in combination with the drug showing favorable safety and tolerance characteristics, is expected to see RVX-208 progress into Phase 2 studies in cardiovascular disease patients.

ApoA-I is the core protein of HDL, often termed the good cholesterol, and ApoA-I is generally endorsed as a key protective factor against atherosclerosis and cardiovascular disease. Developing small molecules increasing ApoA-I would satisfy a huge unmet medical need. This selective early analysis will be communicated in private meetings at the European Society of Cardiology starting at the end of this month. The plasma ApoA-I increase is significant during treatment and at the lowest dose, while continued increases follow a dose-response and time-response pattern. This data is building on similar results from non-human primate studies and a previous 7-day study in humans last year that also showed significant ApoA-I increases. The safety data has not yet been compiled according to who received active or placebo treatment, nevertheless, based on the number and degree of adverse events in total, safety blood analysis and conduct of the study it can be concluded that RVX-208 is safe and tolerable at doses efficient in increasing plasma ApoA-I concentrations.

A protocol is being been compiled together with the IVUS Steering Committe
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SOURCE Resverlogix Corp.
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