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Results From Neurotech's NT-501 Phase 2 Retinitis Pigmentosa Studies Demonstrate Consistent Biological Effect on Photoreceptors
Date:5/28/2009

short 12-month time period," added Dr. Birch.

"We are encouraged with the consistent biological effects of CNTF observed in these two Phase 2 RP studies," commented Ted Danse, President and Chief Executive Officer of Neurotech. "We will continue to follow the patients in these studies and plan to discuss the results and the clinical development path with the Food and Drug Administration (FDA)," added Mr. Danse.

"We are pleased that the NT-501 treatment has shown a positive biological effect on the retina in these two clinical trials, and we are hopeful that vision preservation will be observed when all information is available at the conclusion of the clinical trials," stated Stephen Rose, PhD, Chief Research Officer, Foundation Fighting Blindness. "We are very proud of our long-term support for NT-501 and the innovative ECT technology."

Explants of 25 NT-501 devices from these two studies were prospectively performed between 12 and 24 months following implantation. All have been found to have uniformly healthy, viable cells that continue to produce therapeutic levels of CNTF. This is consistent with data from multiple trials of NT-501 in which, to date, 40 devices have been explanted between 6 and 24 months following implantation and all devices have contained healthy, viable CNTF-producing cells.

"We are very excited about the ability of our ECT platform to deliver a variety of therapeutic factors in a consistent, long-term and well-controlled manner," said Danse. "In addition to these RP studies, we are actively developing NT-501 for geographic atrophy associated with dry AMD, and plan to initiate a Phase 1 study for our second product candidate, NT-503, in wet AMD in the second half of this year. NT-503 inhibits a well-validated target in wet AMD, VEGF, and has the potential to provide a one-time administration for a 12 to 18 month period versus the current wet AMD treatment regimen that requi
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SOURCE Neurotech Pharmaceuticals, Inc.
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