Navigation Links
Restoring blood flow
Date:8/1/2011

tissue half-life, limiting its potency and requiring repeat dosing. By virtue of its engineering, this nanomaterial mimics VEGF but is capable of much longer life in the tissue, greatly enhancing its potency."

Losordo also is the Eileen M. Foell Professor of Heart Research at Northwestern's Feinberg School of Medicine and director of the Program in Cardiovascular Regenerative Medicine at Northwestern Memorial Hospital.

"We approached this as an engineering problem," said first author Matthew Webber, a doctoral student in Stupp's research group at the Institute for BioNanotechnology in Medicine (IBNAM). "To be able to design and create a small molecule that can assemble into nanostructures that function therapeutically is rewarding."

Stupp and his team created a nanostructure in the form of a fiber that displays on its surface a high density of peptides (potentially hundreds of thousands) per fiber. The peptides mimic the biological effect of VEGF, initiating the signaling process in cells that leads to blood vessel growth.

The extremely large number of active peptides results in a very potent therapeutic, and the size and stability of the nanofiber ensure the structure is retained longer in the tissue after injection.

After developing the nanostructure, Stupp and Webber teamed up with Losordo to test the nanostructures in vivo.

The researchers used an animal model of peripheral arterial disease and demonstrated the effectiveness of the nanofiber in treating the condition. In animals whose limbs were restricted to only 5 to 10 percent of normal blood flow, treatment with the nanofiber resulted in blood flow being restored to 75 to 80 percent of normal levels.

Treatment with the peptide alone did not produce the same therapeutic effect; the nanostructure was needed to display the peptides to produce results.

"Using simple chemistry, we have produced an artificial structure by design that can tr
'/>"/>

Contact: Megan Fellman
fellman@northwestern.edu
847-491-3115
Northwestern University
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. FDA Grants Full Approval of PROCLEIX(R) ULTRIO(R) Blood Screening Assay
2. Biotest Diagnostics Receives FDA Clearance for Full Line of Traditional Blood Bank Reagents
3. Limbs saved by menstrual blood stem cells
4. Sanofi Aventis : New Study Results Support the "Basal Plus" Strategy With LANTUS(R) and APIDRA(R) to Improve Blood Sugar Control in Patients With Type 2 Diabetes
5. Human Trial Results Show Plant Extract Tops Drug at Regulating Blood Sugar Levels; Huge Market Seen for Newly Developed Food Additive Emulin™
6. No Blood Needed Thanks to Innovative Medical Technology
7. The Modern DeBakey VAD™ To Be Introduced For the First Time in the U.S. : HeartAssist 5™ Pediatric VAD Features Industry Exclusive Direct Blood Flow Measurement System
8. Cepheid Receives FDA Clearance for First On-Demand Diagnostic Test for Life-Threatening MRSA and Staphylococcus aureus From Patient Positive Blood Cultures
9. CORD:USE Cord Blood Bank is Proud to Announce that Cord Blood Pioneer and Leading Transplanter Dr. Eliane Gluckman has Joined its Team
10. American Red Cross Expands Agreement for Strategic Blood Management(TM) Services from Strategic Healthcare Group LLC
11. China Biologic Products Enters Into Agreement to Acquire 35% Interest in Xian Huitian Blood Products Co., Ltd. and Introduces Preliminary Guidance for 2009
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2015)... ... ... Capital Edge Consulting , a nationwide consulting firm that specializes in helping ... one of the top 5000 companies listed on the 2015 Inc. 5000 , ... is truly an honor to be recognized as one of America’s fastest growing companies. ...
(Date:8/27/2015)... MENLO PARK, Calif. , Aug. 27, 2015 /PRNewswire/ ... company in the emerging field of regenerative medicine, today ... two investor conferences in the month of September.  ... Officer, will present at Rodman & Renshaw,s 17th Annual ... 10:25am ET/7:25am PT at the St. Regis Hotel in ...
(Date:8/27/2015)... , ... August 27, 2015 , ... Inc. Magazine released ... ranking iLab Solutions as number 1,361 in growth for the three years through 2014. ... top 0.1% fastest-growing privately held organizations in the country. , “We are thrilled ...
(Date:8/26/2015)... ... August 26, 2015 , ... MediVet Biologics, a leader in ... is to open in Manhattan, Kansas in early October, 2015. The location of ... research and development through collaboration with researchers from Kansas State University’s College of ...
Breaking Biology Technology:Capital Edge Consulting Makes Inc. 5000 List of America’s Fastest-Growing Private Companies 2Capital Edge Consulting Makes Inc. 5000 List of America’s Fastest-Growing Private Companies 3Asterias Biotherapeutics to Present at Upcoming Investor Conferences 2iLab Solutions Named to 2015 Inc. 5000 List 2iLab Solutions Named to 2015 Inc. 5000 List 3MediVet Biologics Animal Health Secures Additional Laboratory Facility in Manhattan, Kansas 2MediVet Biologics Animal Health Secures Additional Laboratory Facility in Manhattan, Kansas 3
... The 14th Annual National Ergonomics,Conference and Exposition (NECE) ... a record number of conference sessions, and mark ... geared toward workplace design,and occupational health professionals, as ... environments. These new tracks are coupled with,the NECE,s ...
... AEterna Zentaris Inc.,(NASDAQ: AEZS , TSX: AEZ), ... oncology, today announced that its Senior Vice,President and ... a,company overview at the upcoming CIBC World Markets ... 2008 at 3:25 pm (eastern,time), at the Centre ...
... Shandong, China, Sept. 17 /Xinhua-PRNewswire-FirstCall/ --,China Biologic ... Biologic",or the "Company"), one of the leading ... China ("PRC"), today announced that the Company,received ... Drug Administration (the,"SFDA") to commence clinical trial ...
Cached Biology Technology:2008 National Ergonomics Conference Schedule Announced, Features Four New Tracks of Programming and Focus on Corporate Sustainability and Productivity; Most Product Debuts in Expo's 14-Year History 22008 National Ergonomics Conference Schedule Announced, Features Four New Tracks of Programming and Focus on Corporate Sustainability and Productivity; Most Product Debuts in Expo's 14-Year History 3China Biologic Receives SFDA Approval for Clinical Trial of Human Coagulation Factor VIII 2China Biologic Receives SFDA Approval for Clinical Trial of Human Coagulation Factor VIII 3
(Date:8/6/2015)... , Aug. 6, 2015 Synaptics Inc. ... human interface solutions, today announced collaboration with Microsoft ... Windows 10. Microsoft leveraged Synaptics, deep expertise in ... system. Through stringent testing, Synaptics, ... certified with Microsoft,s Precision TouchPad (PTP) specification empowering ...
(Date:8/5/2015)... MOUNTAIN VIEW, Calif. , Aug. 5, 2015 /PRNewswire/ ... it exhibits continuous growth in applications, penetration into newer ... year after year. The global biosensors space has seen ... having exited the market so far. (Photo ... from Frost & Sullivan, Analysis of the Global ...
(Date:8/3/2015)... , Aug. 3, 2015 Synaptics, Inc. ... interface solutions, today announced that members of the executive ... the Pacific Crest Global Technology Leadership Forum on Tuesday, ... conference will be held at the Sonnenalp Resort in ... The presentation may include forward-looking information. An audio webcast ...
Breaking Biology News(10 mins):Synaptics Chosen for Human Interface Co-Development on Windows 10 2Innovative Biosensors Incite Use in Non-Traditional Applications 2Innovative Biosensors Incite Use in Non-Traditional Applications 3Innovative Biosensors Incite Use in Non-Traditional Applications 4
... Tuberculosis remains one of the deadliest threats to public ... the disease, which is caused by the microorganism Mycobacterium ... infected and more and more bacterial strains have developed ... the European Molecular Biology Laboratory (EMBL) and the Max ...
... future use of stem cells to treat heart disease, ... of Nature (June 29, 2006). , Authored by ... and Gladstone Institutes postdoctoral scholar Kathryn Ivey, PhD, the ... of research: the developmental processes within the ...
... -A new imaging method has revealed early signs of emphysema ... to a study published in the June issue of Radiology. ... a new magnetic resonance imaging (MRI) technique that appears to ... current modality of choice, computed tomography (CT). , "With this ...
Cached Biology News:New potential drug target in tuberculosis 2Progress being made in exploring potential use of stem cells to treat heart disease 2New MRI technique shows emphysema in asymptomatic smokers 2
Anti-human L-Ficolin, Clone GN4, Monoclonal Antibody...
14-3-3 tau Antibody Shipping Temperature: HOT Storage Temperature: -20C...
Applications: Western blotting Stability: Room temperature, indefinitely ...
... Rabbit Antibody to ARG. Vasopressin ... vasopression peptide. Cells are found in ... fibers are found throughout the hypothalmus ... perfused tissue. Immunogen: ...
Biology Products: