Navigation Links
Restoring blood flow
Date:8/1/2011

tissue half-life, limiting its potency and requiring repeat dosing. By virtue of its engineering, this nanomaterial mimics VEGF but is capable of much longer life in the tissue, greatly enhancing its potency."

Losordo also is the Eileen M. Foell Professor of Heart Research at Northwestern's Feinberg School of Medicine and director of the Program in Cardiovascular Regenerative Medicine at Northwestern Memorial Hospital.

"We approached this as an engineering problem," said first author Matthew Webber, a doctoral student in Stupp's research group at the Institute for BioNanotechnology in Medicine (IBNAM). "To be able to design and create a small molecule that can assemble into nanostructures that function therapeutically is rewarding."

Stupp and his team created a nanostructure in the form of a fiber that displays on its surface a high density of peptides (potentially hundreds of thousands) per fiber. The peptides mimic the biological effect of VEGF, initiating the signaling process in cells that leads to blood vessel growth.

The extremely large number of active peptides results in a very potent therapeutic, and the size and stability of the nanofiber ensure the structure is retained longer in the tissue after injection.

After developing the nanostructure, Stupp and Webber teamed up with Losordo to test the nanostructures in vivo.

The researchers used an animal model of peripheral arterial disease and demonstrated the effectiveness of the nanofiber in treating the condition. In animals whose limbs were restricted to only 5 to 10 percent of normal blood flow, treatment with the nanofiber resulted in blood flow being restored to 75 to 80 percent of normal levels.

Treatment with the peptide alone did not produce the same therapeutic effect; the nanostructure was needed to display the peptides to produce results.

"Using simple chemistry, we have produced an artificial structure by design that can tr
'/>"/>

Contact: Megan Fellman
fellman@northwestern.edu
847-491-3115
Northwestern University
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. FDA Grants Full Approval of PROCLEIX(R) ULTRIO(R) Blood Screening Assay
2. Biotest Diagnostics Receives FDA Clearance for Full Line of Traditional Blood Bank Reagents
3. Limbs saved by menstrual blood stem cells
4. Sanofi Aventis : New Study Results Support the "Basal Plus" Strategy With LANTUS(R) and APIDRA(R) to Improve Blood Sugar Control in Patients With Type 2 Diabetes
5. Human Trial Results Show Plant Extract Tops Drug at Regulating Blood Sugar Levels; Huge Market Seen for Newly Developed Food Additive Emulin™
6. No Blood Needed Thanks to Innovative Medical Technology
7. The Modern DeBakey VAD™ To Be Introduced For the First Time in the U.S. : HeartAssist 5™ Pediatric VAD Features Industry Exclusive Direct Blood Flow Measurement System
8. Cepheid Receives FDA Clearance for First On-Demand Diagnostic Test for Life-Threatening MRSA and Staphylococcus aureus From Patient Positive Blood Cultures
9. CORD:USE Cord Blood Bank is Proud to Announce that Cord Blood Pioneer and Leading Transplanter Dr. Eliane Gluckman has Joined its Team
10. American Red Cross Expands Agreement for Strategic Blood Management(TM) Services from Strategic Healthcare Group LLC
11. China Biologic Products Enters Into Agreement to Acquire 35% Interest in Xian Huitian Blood Products Co., Ltd. and Introduces Preliminary Guidance for 2009
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Cambridge Semantics, the leading provider of smart ... 2014 was a record-breaking year across the board for the ... Smart Data Platform and our Smart Data solutions, our customers ... data which led to record growth for the company in ...
(Date:1/22/2015)... zFlo Motion , a US leader in biomechanics ... from a new partner. STT-Systems has developed an ... years, with offerings in the optical-motion capture, 3D scanning, and ... measurement unit), iSen, is opening eyes around the world. With ...
(Date:1/22/2015)... NEW BRUNSWICK , Nueva Jersey , 22 ... Award for Biomedical Research abre hoy su llamada ... las personas cuya investigación científica ha hecho, o tiene ... de la salud humana. Las nominaciones se aceptarán hasta ...
(Date:12/25/2014)... December 25, 2014 The report “Service ... Product Type & Provider Type - Global Advancements, Worldwide ... with an in-depth analysis and forecasting of revenues. ... through 221 pages and in-depth TOC on “Service Quality ...
Breaking Biology Technology:Cambridge Semantics Announces Record Results for 2014 23D Motion Capture Just Got Easy 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4
... pictured here in 2001 in his Primate Center lab. Source: ... anatomy professor James Thomson attempted to separate hype ... cell research, which in some cases uses tissue from human ... 200 at the UW Memorial Union as part of the ...
... offer from one of the employers youve been tangoing with for ... it as getting an interview but squared. It means they really ... are wanted (not to mention the prospect of getting a real ... judgment. , ,Taking a job is not like going on a ...
... it means someone or something from the U.S.A. But the ... jets. Signs in D.C. announce American University. American is well ... of trademarks in the U.S., it is not uncommon for a ... of businesses in different industries. , ,American is also a keyword ...
Cached Biology Technology:UW stem cell guru outlines scientific and political future 2UW stem cell guru outlines scientific and political future 3Ten red flags in your Midwest technology offer letter 2Ten red flags in your Midwest technology offer letter 3Ten red flags in your Midwest technology offer letter 4Ten red flags in your Midwest technology offer letter 5Thats my trademark 2Thats my trademark 3Thats my trademark 4
(Date:12/19/2014)... Inc., the leading personal genetics company, today announced the publication ... of individuals from across the United States ... hundred years ago, the United States ... continents. This study illuminates how American history and the ongoing ...
(Date:12/17/2014)... , Dec. 16, 2014 Valencell, a leader ... PerformTek biometric technology to industry leaders such as Intel, ... clinically validated, biometric wearable products. These products will be ... Las Vegas . ...
(Date:12/11/2014)... DUBLIN , Dec. 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced the addition ... report to their offering. One major ... multimodal biometric systems. Multimodal biometric systems utilize more than ...
Breaking Biology News(10 mins):23andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... 2008The 2008 American Society for Microbiology (ASM) Eli Lilly ... K. Newman, Wilson Professor of Biology and Geobiology, Massachusetts ... unusual merit in microbiology or immunology by an individual ... Dr. Newman is a pioneering young scientist who has ...
... of the future may need to be managed as much ... goal, researchers say in a new federal report but ... the insatiable, often conflicting demands for this precious resource. ... both urban and agricultural demands for water continue to increase, ...
... Society for Microbiology (ASM) William A. Hinton ... Arturo Casadevall, Chair, Department of Microbiology and ... University, New York. This award recognizes outstanding ... underrepresented minorities in microbiology. Dr. Casadevall ...
Cached Biology News:American Society for Microbiology honors Dianne K. Newman 2New report: Greatest value of forests is sustainable water supply 2New report: Greatest value of forests is sustainable water supply 3American Society for Microbiology honors Arturo Casadevall 2