Navigation Links
Researchers write protein nanoarrays using a fountain pen and electric fields
Date:10/13/2008

EVANSTON, Ill. --- Nanotechnology offers unique opportunities to advance the life sciences by facilitating the delivery, manipulation and observation of biological materials with unprecedented resolution. The ability to pattern nanoscale arrays of biological material assists studies of genomics, proteomics and cell adhesion, and may be applied to achieve increased sensitivity in drug screening and disease detection, even when sample volumes are severely limited.

Unfortunately, most tools capable of patterning with such tiny resolution were developed for the silicon microelectronics industry and cannot be used for soft and relatively sensitive biomaterials such as DNA and proteins.

Now a team of researchers at Northwestern University has demonstrated the ability to rapidly write nanoscale protein arrays using a tool they call the nanofountain probe (NFP).

"The NFP works much like a fountain pen, only on a much smaller scale, and in this case, the ink is the protein solution," said Horacio Espinosa, head of the research team and professor of mechanical engineering in the McCormick School of Engineering and Applied Science at Northwestern.

The results, which will be published online the week of Oct. 13 in the Proceedings of the National Academy of Sciences (PNAS), include demonstrations of sub-100-nanometer protein dots and sub-200-nanometer line arrays written using the NFP at rates as high as 80 microns/second.

Each nanofountain probe chip has a set of ink reservoirs that hold the solution to be patterned. Like a fountain pen, the ink is transported to sharp writing probes through a series of microchannels and deposited on the substrate in liquid form.

"This is important for a number of reasons," said Owen Loh, a graduate student at Northwestern who co-authored the paper with fellow student Andrea Ho. "By maintaining the sensitive proteins in a liquid buffer, their biological function is less likely
'/>"/>

Contact: Megan Fellman
fellman@northwestern.edu
847-491-3115
Northwestern University
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Researchers improve ability to write and store information on electronic devices
2. Long-awaited international ethical guidelines for biobank researchers
3. CU researchers shed light on light-emitting nanodevice
4. Stevens researchers provide new information about mass spectrometry
5. Researchers measure carbon nanotube interaction
6. Researchers underscore limitations of genetic ancestry tests
7. ASU researchers improve memory devices using nanotech
8. UD researchers race ahead with latest spintronics achievement
9. Researchers outline structure of largest nonvirus particle ever crystallized
10. Ames Laboratory researchers solve fuel-cell membrane structure conundrum
11. Researchers use magnetism to target cells to animal arteries
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... Due to a misstatement posted by the Family ... Technology Center, LLC ( ASCTC ) was reported as an ... might benefit ALS patients. Because of ASCTC's exclusive focus ... and therapeutic applications, FRC listed ASCTC as one of several ... wish not to support research that requires the death of ...
(Date:8/28/2014)... Best Sanitizers, Inc., a leader in hand ... is asking industry professionals to prepare for fall harvest ... soap they’re currently using to the Best Sanitizers’ ... hygiene is critical to fighting cross-contamination and the spread ... criteria are identified to evaluate the effectiveness of an ...
(Date:8/28/2014)... an electronic which is not only based on ... spin and the spin-related magnetism. Spin-charge converters enable ... vice versa. Recently, the research group of Professor ... Johannes Gutenberg University Mainz in collaboration with researchers ... the first time realised a new, efficient spin-charge ...
(Date:8/28/2014)... SunTrust Robinson Humphrey (STRH) today announced the ... research team in biotechnology and oilfield services.  ... demonstrates our commitment to providing our valued institutional ... decision making," said Biff Woodruff , Head ... significant investments in differentiated content at a time ...
Breaking Biology Technology:The Adult Stem Cell Technology Center, LLC Declines ALS Ice Bucket Challenge Donors Wishing to Support Ethical Research for New Stem Cell Therapies 2The Adult Stem Cell Technology Center, LLC Declines ALS Ice Bucket Challenge Donors Wishing to Support Ethical Research for New Stem Cell Therapies 3Best Sanitizers, Inc. Asks Food Industry Professionals: With Fall Harvest On the Way, Is Your E2 Hand Soap Up to the Task? 2A new, tunable device for spintronics 2A new, tunable device for spintronics 3SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 2SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 3
... system for studying NFAT activation , Li ... Chao-Feng Zheng ,Stratagene , Stratagenes new PathDetect ... for studying the activation of the,nuclear factor of ... play an essential role in inducible gene expression,during ...
... , , , Stratagene introduces the first ... glass slides. These GeneConnection discovery microarrays II , ... , al., 1 can be used ... genes. The microarrays are configured on standard 25 mm x 75 mm glass , ...
... New filter designed for optimal image clarity , ... , Michelle Cayouette Jane Moores ,Stratagene , A new ... ,II Still Video System that increases contrast ... II Still Video System,is currently sold ...
Cached Biology Technology:Cis-Reporting System Monitors Intracellular Calcium Mobilization 2Cis-Reporting System Monitors Intracellular Calcium Mobilization 3Cis-Reporting System Monitors Intracellular Calcium Mobilization 4Cis-Reporting System Monitors Intracellular Calcium Mobilization 5Stratagenes Human cDNA Microarrays: Perform Gene Expression Profiling and,Discover New Genes 2Stratagenes Human cDNA Microarrays: Perform Gene Expression Profiling and,Discover New Genes 3Stratagenes Human cDNA Microarrays: Perform Gene Expression Profiling and,Discover New Genes 4Eagle Eye Optical Filter Optimized for Imaging Silver-Stained,Gels 2Eagle Eye Optical Filter Optimized for Imaging Silver-Stained,Gels 3
(Date:8/29/2014)... German . ... nitrogen cycle on Earth and in biological wastewater treatment ... depend on nitrite as their source of energy. An ... microbiologist at the University of Vienna, has now shown ... source of energy. The oxidation of hydrogen with oxygen ...
(Date:8/29/2014)... twist them, fold them: modern materials that are light, ... as artificial skin or electronic paper. , Making such ... but a new way of working with copper nanowires ... , Previous success in the field of ultra-lightweight ... precious gold and silver nanowires. , By turning ...
(Date:8/28/2014)... researchers have identified a handful of bacterial culprits that ... disease and ulcerative colitis, using patients, own intestinal immune ... Aug. 28 in the journal Cell . , ... which plays a critical role in the development and ... small number of bacterial species affect a person,s susceptibility ...
Breaking Biology News(10 mins):Hydrogen powers important nitrogen-transforming bacteria 2Hydrogen powers important nitrogen-transforming bacteria 3Copper shines as flexible conductor 2Yale study identifies possible bacterial drivers of IBD 2
... with a damaged insula ?a region in the brain linked ... to a study in the Jan. 26 issue of the ... grip on the brain. , It also raises ... strong hold on neural circuits for pleasure. , The ...
... could help control weight, lower fat and cholesterol levels, and ... Chemistry & Industry, the magazine of the SCI. , Yellow ... this is one of the reasons why frozen food manufacturer ... a team of Korean researchers has shown that black soya ...
... worth of statistics, researchers are sounding a new alarm about ... The overall number of syphilis cases in the United States ... perhaps because of a nationwide prevention campaign aimed at heterosexuals. ... this decade. , "The entire nation was caught ...
Cached Biology News:Smokers quit after damage to brain region 2Syphilis rate on rise in US gay, bisexual men 2
... EC570-90 is a compact, lightweight, high current power ... or 2500 milliamps. It is an excellent choice ... gels. It is also ideal for all types ... be set to automatically end a run and ...
... a highly purified preparation qualified to specifically ... The preparation is functionally tested for activity ... detectable contaminating proteases. Prepared from human plasma ... to be negative for HBsAg and for ...
Acetate Plate Sealers 100/Box...
... Buffer is a concentrated formulation of a ... capillary action technology, as well as for ... with David Brigati M.D., Department of Pathology, ... buffer is recommended for all the rinsing ...
Biology Products: