Navigation Links
Researchers visualize herpes virus' tactical maneuver
Date:1/6/2011

For the first time, researchers have developed a 3D picture of a herpes virus protein interacting with a key part of the human cellular machinery, enhancing our understanding of how it hijacks human cells to spread infection and opening up new possibilities for stepping in to prevent or treat infection. This discovery uncovers one of the many tactical manoeuvres employed by the virus.

The Biotechnology and Biological Sciences Research Council (BBSRC)-funded team, led by The University of Manchester, have used NMR - a technique related to the one used in MRI body scanners and capable of visualising molecules at the smallest scales to produce images of a herpes virus protein interacting with a mouse cellular protein. These images were then used to develop a 3D model of this herpes virus protein interacting with human protein. The research is published this evening (06 January) in PLoS Pathogens.

Lead researcher Dr Alexander Golovanov from Manchester's Interdisciplinary Biocentre and Faculty of Life Sciences said "There are quite a few types of herpes viruses that cause problems as mild as cold sores through to some quite serious illnesses, such as shingles or even cancer. Viruses cannot survive or replicate on their own they need the resources and apparatus within a human cell to do so. To prevent or treat diseases caused by viruses we need to know as much as possible about how they do this so that we can spot weak points or take out key tactical manoeuvres."

The 3D model shows how the viral protein piggybacks onto the molecular machinery components inside human cells, promoting virus replication and spread of infection through the body.

"When you look at the image, it's like a backpack on an elephant: the small compact fragment of viral protein fits nicely on the back of the human protein," said Dr Golovanov.

By studying the images along with biochemical experiments using the human version of the cellular protein, the team has uncovered the mechanism by which the viral and cellular proteins work together to guide the viral genetic material out of the cell's nucleus. Once there, the genetic material can be utilized to make proteins that are used as building blocks for new viruses. The researchers have also confirmed that this relationship between the two proteins exists for related herpes viruses that infect monkeys.

Dr Golovanov continued "Our discovery gives us a whole step more detail on how herpes viruses use the human cell to survive and replicate. This opens up the possibilities for asking new questions about how to prevent or treat the diseases they cause."

Professor Janet Allen, BBSRC Director of Research said "This new research gives us an important piece of the jigsaw for how a particular viral infection works on a molecular level, which is great news. Understanding the relationship between a human, animal or plant the host and the organisms that cause disease pathogens is a fundamental step toward successful strategies to minimise the impact of infection. To study host-pathogen relationships we have to look in detail at the smallest scale of molecules as this study does and also right through to the largest scale of how diseases work in whole systems a crop disease in the context of a whole area of agricultural land, for example. BBSRC's broad portfolio of research into host-pathogen relationships facilitates this well."


'/>"/>

Contact: Nancy Mendoza
press.office@bbsrc.ac.uk
44-179-341-3355
Biotechnology and Biological Sciences Research Council
Source:Eurekalert

Related biology technology :

1. Thomson Reuters and ChemAxon Partner to Help Speed Drug Discovery for Life Science Researchers
2. Strange new twist: Berkeley researchers discover Möbius symmetry in metamaterials
3. Rice researchers take molecules temperature
4. Researchers create new high-performance fiber
5. Dutch royal honors for Manchester researchers
6. Virtual reality helps researchers track how brain responds to surroundings
7. Elsevier Releases Image Search; New SciVerse ScienceDirect Feature Enables Researchers to Quickly Find Reliable Visual Content
8. LSU researchers awarded 1 of the largest NSF grants in Louisiana history
9. Researchers find Goldilocks of DNA self-assembly
10. Plague researchers race to beat bioterrorists
11. Microsoft Research Makes Microsoft Biology Foundation and MODISAzure-Based Environmental Service Available to Scientists and Researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2017)... (PRWEB) , ... April 20, 2017 , ... Parallel6™ ... clinical trials worldwide, announced today that they were named one of the 2017 ... covers the latest developments in the pharmaceutical industry. , “We take pride in honoring ...
(Date:4/20/2017)... For today, Stock-Callers.com redirects investors, attention to Biotechnology, ... research aimed at treating diseases and medical conditions. Under evaluation ... (NASDAQ: KERX), Kite Pharma Inc. (NASDAQ: KITE), and ZIOPHARM Oncology ... complimentary research reports on these stocks now at: ... http://stock-callers.com/registration Biostage ...
(Date:4/19/2017)... ... April 18, 2017 , ... Optofluidics today announced that ... after the company changed focus to making analytical tools for biopharmaceutical quality control. ... technology,” says CEO Robert Hart. Founders Bernardo Cordovez, Robert Hart and David Erickson ...
(Date:4/19/2017)... ... April 19, 2017 , ... As part of ... accessible to novices as well as experienced users, attendees will gain a better ... screening tests. , Hemostasis testing quality is determined by preanalytical variables which ...
Breaking Biology Technology:
(Date:4/3/2017)... 3, 2017  Data captured by IsoCode, ... detected a statistically significant association between the ... treatment and objective response of cancer patients ... predict whether cancer patients will respond to ... well as to improve both pre-infusion potency testing ...
(Date:3/30/2017)... 30, 2017 The research team of The ... (3D) fingerprint identification by adopting ground breaking 3D fingerprint minutiae recovery ... of speed and accuracy for use in identification, crime investigation, immigration ... ... A research team ...
(Date:3/29/2017)...  higi, the health IT company that operates the ... , today announced a Series B investment from ... The new investment and acquisition accelerates higi,s strategy to ... population health activities through the collection and workflow integration ... collects and secures data today on behalf of over ...
Breaking Biology News(10 mins):