Navigation Links
Researchers use nanoparticles to deliver vaccines to lungs
Date:9/25/2013

, and mucosal vaccines against cholera, rotavirus and typhoid fever.

To create better ways of delivering such vaccines, Irvine and his colleagues built upon a nanoparticle they developed two years ago. The protein fragments that make up the vaccine are encased in a sphere made of several layers of lipids that are chemically "stapled" to one another, making the particles more durable inside the body.

"It's like going from a soap bubble to a rubber tire. You have something that's chemically much more resistant to disassembly," Irvine says.

This allows the particles to resist disintegration once they reach the lungs. With this sturdier packaging, the protein vaccine remains in the lungs long enough for immune cells lining the surface of the lungs to grab them and deliver them to T cells. Activating T cells is a critical step for the immune system to form a memory of the vaccine particles so it will be primed to respond again during an infection.

Stopping the spread of infection

In studies of mice, the researchers found that HIV or cancer antigens encapsulated in nanoparticles were taken up by immune cells much more successfully than vaccine delivered to the lungs or under the skin without being trapped in nanoparticles.

HIV does not infect mice, so to test the immune response generated by the vaccines, the researchers infected the mice with a version of the vaccinia virus that was engineered to produce the HIV protein delivered by the vaccine.

Mice vaccinated with nanoparticles were able to quickly contain the virus and prevent it from escaping the lungs. Vaccinia virus usually spreads to the ovaries soon after infection, but the researchers found that the vaccinia virus in the ovaries of mice vaccinated with nanoparticles was undetectable, while substantial viral concentrations were found in mice that received other forms of the vaccine.

Mice that received the nanoparticle vaccine lo
'/>"/>

Contact: Andrew Carleen
acarleen@mit.edu
617-253-1682
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. New England Biolabs Introduces Polbase, an Information Repository of Scientific Data for Polymerase Researchers
2. In new quantum-dot LED design, researchers turn troublesome molecules to their advantage
3. Multidisciplinary team of researchers develop world’s lightest material
4. Researchers shrink tumors and minimize side effects using tumor-homing peptide to deliver treatment
5. Innovative MetaMorph® NX Software Shatters Barriers Between Researchers and Image Analysis Goals with Exclusive Visual Workflow
6. UCLA researchers demonstrate fully printed carbon nanotube transistor circuits for displays
7. Penn and Brown researchers demonstrate earthquake friction effect at the nanoscale
8. Two Top Biological Imaging Centers Offer Powerful Free Online Tool to Researchers, Educators, and Public
9. Researchers develop one of the worlds smallest electronic circuits
10. MU researchers identify key plant immune response in fight against bacteria
11. Researchers realize high-power, narrowband terahertz source at room temperature
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/31/2014)... (PRWEB) October 31, 2014 Following the ... a free learning webinar to introduce its new product ... directors and biostatisticians. , Launched in September, Formedix On ... suite of clinical trial automation tools. For the first ... web browser. And by introducing Formations – a revolutionary ...
(Date:10/31/2014)... 31, 2014 ENVIRON , ... announced today that Dr. Harvey Clewell III has ... will work closely with senior professionals in ENVIRON’s ... to serve at The Hamner Institutes for Health ... Carolina, where he is Director, Center for Human ...
(Date:10/30/2014)... October 30, 2014 The report “Fragrance ... by Application (Cosmetics & Toiletries, and Soaps & Detergents) ... 2019”, has defined and segmented the Fragrance Ingredients Market ... in terms of value. The market has been segmented ... America, Europe, Asia-Pacific, Latin America, and Rest of the ...
(Date:10/30/2014)... 30, 2014 2014 Deep Research ... is a professional and in-depth research report on ... Naltrexone HCL information, including its definition, classification, application, ... overview. This research covers the international market analysis, ... industry analysis covering macroeconomic environment & economic situation ...
Breaking Biology Technology:Formedix to Introduce "Revolutionary" Clinical Trial Automation Software with Learning Webinar 2Internationally recognized health scientist Dr. Harvey Clewell renews association with ENVIRON 2Internationally recognized health scientist Dr. Harvey Clewell renews association with ENVIRON 3Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 2Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 3Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 4Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 5Naltrexone HCL Market & Nalbuphine HCL Industry Analysis for Global, China Regions Now at DeepResearchReports.com 2Naltrexone HCL Market & Nalbuphine HCL Industry Analysis for Global, China Regions Now at DeepResearchReports.com 3
... 30 ChemRisk, a leading scientific,consulting firm, was ... examine,the recent publication by Institute for Agriculture and ... High Fructose Corn Syrup," and the,Environmental Health journal ... product sugar," by Dufault et al, 2009, and ...
... risk factors better than standard cholesterol test and traditional ... Traditional risk factors such as age, standard cholesterol ... predicting heart disease risk in younger, healthy adults with ... to a recent study published in Clinical Cardiology ...
... Mass., Jan. 30 Jeff Olson, Manager of Nucleic ... Enrichment of Genomic Loci for Targeted Sequencing Applications ... RainStorm micro-droplet technology on the new RDT 1000 instrument, ... (AGBT) conference on Friday, February 6th, in Marco Island, ...
Cached Biology Technology:Recent Reports Regarding Mercury and High Fructose Corn Syrup Flawed and Misleading 2Recent Reports Regarding Mercury and High Fructose Corn Syrup Flawed and Misleading 3Recent Reports Regarding Mercury and High Fructose Corn Syrup Flawed and Misleading 4Traditional Risk Factors Often Miss Heart Disease Warning Signs 2Traditional Risk Factors Often Miss Heart Disease Warning Signs 3Traditional Risk Factors Often Miss Heart Disease Warning Signs 4'Enrichment of Genomic Loci for Targeted Sequencing Application' Is Focus of 2009 AGBT Conference Workshop 2'Enrichment of Genomic Loci for Targeted Sequencing Application' Is Focus of 2009 AGBT Conference Workshop 3
(Date:10/29/2014)... rage. Thousands of scientists worldwide are conducting research on ... nanoparticles from sun creams can get through the skin ... products are as hazardous for the lungs as asbestos ... get into the blood via the intestinal flora, for ... – and the number of scientific projects is skyrocketing: ...
(Date:10/29/2014)... to as ,facultative, form part—together with other cells—of tissues ... cells from the others. However, they have a very ... stem cells again. This phenomenon is something that happens ... stimulate tissue growth, thus allowing the regeneration of the ... the underlying mechanism that allows these cells to ...
(Date:10/29/2014)... – Ghrelin is a hormone released by the stomach ... commonly viewed as a psychoactive substance that primarily affects ... food. , This knowledge, combined with findings from ... has the potential to stimulate alcohol craving. , Dr. ... and found that, as they had anticipated, alcohol craving ...
Breaking Biology News(10 mins):Nanosafety research: The quest for the gold standard 2Nanosafety research: The quest for the gold standard 3A mechanism that allows a differentiated cell to reactivate as a stem cell revealed 2Ghrelin stimulates an appetite for drinking alcohol 2
... VEGAS , Jan. 7, 2014 from ShowStoppers @ ... of securing consumer data on mobile and other digital devices, ... data once it leaves the device and enters the cloud. ... announced the formalization of its Biometric Open Standards Protocols (BOPS). ...
... This news release is available in Portuguese . ... is available in Portuguese . , ... goes beyond the presence or absence of wings. In a study published ... Keller and Patrcia Beldade from the Instituto Gulbenkian de Cincia (IGC, ...
... underrepresented among speakers at scientific meetings, both in absolute ... a new study suggests one way to address this ... published in mBio , the online open-access journal ... inclusion of at least one woman on a convening ...
Cached Biology News:Hoyos Labs Issues Biometric Open Protocol Standard for Safer Authentication 2Hoyos Labs Issues Biometric Open Protocol Standard for Safer Authentication 3Ants shape their thoraces to match the tasks they perform 2Ants shape their thoraces to match the tasks they perform 3Including women on convening committees increases women speakers at scientific meetings 2
Recombinant DNA polymerase from Thermus aquaticus expressed in E. coli; 5 units/uL; 25 tubes of 1, 000 units enzyme/tube w/ Buffer I...
Taq DNA Polymerase (cloned), 250 units. Category: Nucleotides & Enzymes & Biochemicals, Modifying Enzymes, Polymerases....
Request Info...
Request Info...
Biology Products: