Navigation Links
Researchers use genomics to investigate TB outbreak
Date:2/25/2011

Vancouver, BC - Scientists supported by Genome BC have set a new standard for studying outbreaks of infectious disease by combining advanced genomics with a detailed map of the social relationships between cases to investigate a recent outbreak of tuberculosis in a BC community.

The study tracked 41 individuals who developed tuberculosis: patient interviews revealed a tightly-knit community where most patients knew one another, while DNA fingerprinting of the bacterial samples from each individual showed them to be identical to each other. These two factors together made reconstructing the outbreak family tree impossible.

In order to get a more detailed picture of how TB spread through the community, researchers from the BC Centre for Disease Control (BCCDC), Canada's Michael Smith Genome Sciences Centre and Simon Fraser University turned to whole genome sequencing to discern subtle genetic differences between different bacterial strains. These slight differences allowed them to identify individual transmission events, in which one patient can be identified as the most likely source of the subsequent patient's infection. By looking at all of the transmission events revealed by the data, the researchers were able to identify not only where the outbreak organism had originated, but also how it had moved throughout the community.

"Genome sequencing used to be prohibitively expensive, so it was simply impossible to sequence the bacteria from all the patients involved in an outbreak and we had to go with the next best thing, DNA fingerprinting," says Dr. Jennifer Gardy at the BCCDC. "Now, however, sequencing tens, hundreds, or thousands of bacterial isolates is very doable in a reasonable timeframe and at a manageable cost. We can figure out how these bacteria are related to each other by comparing their genome sequences, and when we overlay that information onto a map of the social relationships between cases we can actually reconstruct
'/>"/>

Contact: Jenny Boon
jboon@genomebc.ca
778-327-8374
Genome BC
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Quantum hot potato: NIST researchers entice 2 atoms to swap smallest energy units
2. Researchers get a grip on nervous systems receptors
3. Researchers at Harvard and MITRE produce worlds first programmable nanoprocessor
4. Size of airborne flu virus impacts risk, Virginia Tech researchers say
5. What a ride! Researchers take molecules for a spin
6. Practice Fusion Invites Health Researchers to Analyze This! Contest on Windows Azure
7. Columbia University researchers use nanoscale transistors to study single-molecule interactions
8. Researchers visualize herpes virus tactical maneuver
9. Thomson Reuters and ChemAxon Partner to Help Speed Drug Discovery for Life Science Researchers
10. Strange new twist: Berkeley researchers discover Möbius symmetry in metamaterials
11. Rice researchers take molecules temperature
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... September 30, 2014 Rainbow Scientific, ... research products, recently opened an online store to ... culture product lines developed and manufactured by Biological ... store include Biological Industries’ Nutristem® serum-free, xeno-free reagents ... embryonic stem cell (hESC) culture. , The ...
(Date:9/30/2014)... Whitehouse Laboratories is pleased to ... Parenteral Drug Association (PDA) to host a unique ... closure integrity testing. This lecture/laboratory course will examine the ... detailed in the recently proposed revision to USP 1207 ... will span container closure integrity testing (leak testing) critical ...
(Date:9/29/2014)... 30, 2014 Each year in ... require medical attention. In the military, burn injury ... to battlefield medical care. More than 800 service ... Burn wounds heal slowly, remain inflamed and often ... physically debilitating and functionally damaging. While developments in ...
(Date:9/29/2014)... BEACH, Va. , Sept. 29, 2014 /PRNewswire-USNewswire/ ... from the fields of cartilage repair, regeneration, allograft ... attendees from around the world gathered to discuss ... LifeNet Health Institute of Regenerative Medicine symposium, ... Direction . Topics included Orthopedic Biosurgery, Minced Juvenile ...
Breaking Biology Technology:Rainbow Scientific, Inc. opens online store for state-of-the-art stem cell culture and cytogenetic reagents 2Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 2Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 3Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 4Faster Healing with Fewer Scars 2World Renowned Experts Discuss Future Of Cartilage Regeneration 2World Renowned Experts Discuss Future Of Cartilage Regeneration 3
... Organization Exceeds Expectations, MEMPHIS, Tenn., Nov. ... exclusively focused on oncology, announced today that ... as the company continues,to experience banner growth. ... to consistently exceed client expectations, and we ...
... N.J., Nov. 10 Aton Pharma, Inc., ... a recent,survey of ophthalmologists regarding issues in ... dry eye. Aton provides the dry eye ... sustained release prescription insert that helps to ...
... 3SBio Inc. (Nasdaq:,SSRX), a leading biotechnology company focused ... in China,today announced that it has filed with ... approval of NuLeusin for the treatment of late,stage ... expected to,be the only treatment of this kind ...
Cached Biology Technology:ACORN CRO Continues Growth in Strong Third Quarter 2Dry Eye Survey: Ophthalmologists Cite Treatment Limitations/Gaps in Treatment of Moderate to Severe Dry Eye 2Dry Eye Survey: Ophthalmologists Cite Treatment Limitations/Gaps in Treatment of Moderate to Severe Dry Eye 3Dry Eye Survey: Ophthalmologists Cite Treatment Limitations/Gaps in Treatment of Moderate to Severe Dry Eye 4Dry Eye Survey: Ophthalmologists Cite Treatment Limitations/Gaps in Treatment of Moderate to Severe Dry Eye 53SBio Inc. Files for SFDA Approval of NuLeusin 23SBio Inc. Files for SFDA Approval of NuLeusin 33SBio Inc. Files for SFDA Approval of NuLeusin 4
(Date:9/29/2014)... research team says recently identified radiation detection properties of ... doors for homeland security and medical advances. , In ... issue of Optics Letters , UT Arlington Physics ... method to fabricate transparent nanoscintillators by heating nanoparticles composed ... is formed. A scintillator refers to a material ...
(Date:9/29/2014)... has presented Dr. Cristin Samper, president and CEO ... Order of San Carlos. , The Order of ... military officers who have made outstanding contributions to ... relations. , An international authority on conservation biology ... the Colombian Residence in New York to receive ...
(Date:9/29/2014)... annual Advocacy Awards will ... advancing medical progress to improve the health and ... take place on Wednesday, March 11, 2015, at ... , The 2015 Advocacy Award winners are ABC,s ... founder of the Milken Institute and FasterCures; Dr. ...
Breaking Biology News(10 mins):UT Arlington researchers develop new transparent nanoscintillators for radiation detection 2UT Arlington researchers develop new transparent nanoscintillators for radiation detection 3Research!America to honor leaders in medical and health research advocacy 2Research!America to honor leaders in medical and health research advocacy 3Research!America to honor leaders in medical and health research advocacy 4
... warming despite emitting small amounts of an important greenhouse gas, ... of Edinburgh suggests that plant leaves account for less than ... is considered to be about 25 times more effective than ... a previous scientific study which had suggested that plants were ...
... WASHINGTON, April 29, 2010 The American Chemical ... has awarded its 2010 research grant to Scottish ... strides in expanding green chemistry and engineering practices ... the one-year $150,000-grant to further his study of ...
... Thomas Miller , an internationally recognized expert at ... and genetics, has been chosen by the U.S. Department ... Fellowship . Miller is one of only ten ... applicants undergo a rigorous selection process, are highly accomplished ...
Cached Biology News:ACS Green Chemistry Institute Pharmaceutical Roundtable award goes to Scottish chemist 2US Department of State names UCR entomologist a Jefferson Science Fellow 2US Department of State names UCR entomologist a Jefferson Science Fellow 3