Navigation Links
Researchers use genomics to investigate TB outbreak
Date:2/25/2011

Vancouver, BC - Scientists supported by Genome BC have set a new standard for studying outbreaks of infectious disease by combining advanced genomics with a detailed map of the social relationships between cases to investigate a recent outbreak of tuberculosis in a BC community.

The study tracked 41 individuals who developed tuberculosis: patient interviews revealed a tightly-knit community where most patients knew one another, while DNA fingerprinting of the bacterial samples from each individual showed them to be identical to each other. These two factors together made reconstructing the outbreak family tree impossible.

In order to get a more detailed picture of how TB spread through the community, researchers from the BC Centre for Disease Control (BCCDC), Canada's Michael Smith Genome Sciences Centre and Simon Fraser University turned to whole genome sequencing to discern subtle genetic differences between different bacterial strains. These slight differences allowed them to identify individual transmission events, in which one patient can be identified as the most likely source of the subsequent patient's infection. By looking at all of the transmission events revealed by the data, the researchers were able to identify not only where the outbreak organism had originated, but also how it had moved throughout the community.

"Genome sequencing used to be prohibitively expensive, so it was simply impossible to sequence the bacteria from all the patients involved in an outbreak and we had to go with the next best thing, DNA fingerprinting," says Dr. Jennifer Gardy at the BCCDC. "Now, however, sequencing tens, hundreds, or thousands of bacterial isolates is very doable in a reasonable timeframe and at a manageable cost. We can figure out how these bacteria are related to each other by comparing their genome sequences, and when we overlay that information onto a map of the social relationships between cases we can actually reconstruct
'/>"/>

Contact: Jenny Boon
jboon@genomebc.ca
778-327-8374
Genome BC
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Quantum hot potato: NIST researchers entice 2 atoms to swap smallest energy units
2. Researchers get a grip on nervous systems receptors
3. Researchers at Harvard and MITRE produce worlds first programmable nanoprocessor
4. Size of airborne flu virus impacts risk, Virginia Tech researchers say
5. What a ride! Researchers take molecules for a spin
6. Practice Fusion Invites Health Researchers to Analyze This! Contest on Windows Azure
7. Columbia University researchers use nanoscale transistors to study single-molecule interactions
8. Researchers visualize herpes virus tactical maneuver
9. Thomson Reuters and ChemAxon Partner to Help Speed Drug Discovery for Life Science Researchers
10. Strange new twist: Berkeley researchers discover Möbius symmetry in metamaterials
11. Rice researchers take molecules temperature
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... (PRWEB) September 18, 2014 Pipette.com ... include Sartorius/Biohit, Socorex, Capp, and AccuPet brand of ... of 100 uL or less and are a ... forensic applications. , The micropipette promotions were ... and economic alternative products to help customers find ...
(Date:9/17/2014)... SAN FRANCISCO , Sept. 17, 2014 /PRNewswire/ ... patients receiving accelerated partial breast irradiation (APBI) via ... and those with positive lymph nodes could be ... for Radiation Oncology (ASTRO) guidelines place these patients ... an abstract at the 2014 ASTRO meeting, Beaumont ...
(Date:9/17/2014)... SAN DIEGO and PRINCETON, N.J. ... Inc. (NASDAQ: OTCQB:AEMD), the pioneer in developing targeted therapeutic ... conditions, and its diagnostic subsidiary, Exosome Sciences, Inc. (ESI), ... the 2014 Exosomes & SingleCell Analysis Summit. ... of Exosome Sciences will give a presentation entitled: "Exosomes: ...
(Date:9/17/2014)... 17, 2014 JH Technologies ... located in Irvine. JH Technologies, a leader in ... recently announced an expanded partnership with Leica Microsystems into ... and image analysis solutions will be featured at the ... The new showroom facility is located within the JH ...
Breaking Biology Technology:Major Pipette Distributor Pipette.com Announces Promotions on Sartorius/Biohit, Socorex, Capp, and AccuPet Micropipettes 2Major Pipette Distributor Pipette.com Announces Promotions on Sartorius/Biohit, Socorex, Capp, and AccuPet Micropipettes 3Partial Breast Irradiation With Interstitial Brachytherapy Appears Appropriate For Women Previously Considered Unsuitable 2Partial Breast Irradiation With Interstitial Brachytherapy Appears Appropriate For Women Previously Considered Unsuitable 3Partial Breast Irradiation With Interstitial Brachytherapy Appears Appropriate For Women Previously Considered Unsuitable 4Aethlon Medical and Exosome Sciences To Present at the Exosomes & SingleCell Analysis Summit 2Aethlon Medical and Exosome Sciences To Present at the Exosomes & SingleCell Analysis Summit 3JH Technologies displays newest microscope imaging technology at Southern California showroom grand opening 2JH Technologies displays newest microscope imaging technology at Southern California showroom grand opening 3
... , Prepare DNA from blood, cultured cells, or bacteria: ... for 1530 min, then , boil for 8 min. ... , substrate for PCR amplification. , ... Use whole blood samples that are frozen, refrigerated, or collected fresh. , ...
... Genomic DNA Isolation Kit , Catalog #732-6340 , ... Method , Cell ... cerebrospinal fluid, plasma, saliva, serum, , sputum, synovial fluid, urine, whole ... 5 ml cell lysis solution. Pipet up and down several times , ...
... Ph.D. , MJ Research, Inc., South San Francisco, ... Abstract , We present a ... and quantitation of soy genetically modified to be resistant to the herbicide , ... of the genetically modified organism (GMO) specific sequences as ...
Cached Biology Technology:InstaGene Matrix: Prepare DNA Templates for PCR With No Phenol/Chloroform Extractions and No Deproteinization Steps, Rev C 2Genomic DNA Isolation From 1 ml of Body Fluid 2Detection of Genetically Modified Soybean in Processed Foods Using Real-Time Quantitative PCR with SYBR Green I Dye on the DNA Engine Opticon 2 System 2Detection of Genetically Modified Soybean in Processed Foods Using Real-Time Quantitative PCR with SYBR Green I Dye on the DNA Engine Opticon 2 System 3Detection of Genetically Modified Soybean in Processed Foods Using Real-Time Quantitative PCR with SYBR Green I Dye on the DNA Engine Opticon 2 System 4Detection of Genetically Modified Soybean in Processed Foods Using Real-Time Quantitative PCR with SYBR Green I Dye on the DNA Engine Opticon 2 System 5Detection of Genetically Modified Soybean in Processed Foods Using Real-Time Quantitative PCR with SYBR Green I Dye on the DNA Engine Opticon 2 System 6Detection of Genetically Modified Soybean in Processed Foods Using Real-Time Quantitative PCR with SYBR Green I Dye on the DNA Engine Opticon 2 System 7Detection of Genetically Modified Soybean in Processed Foods Using Real-Time Quantitative PCR with SYBR Green I Dye on the DNA Engine Opticon 2 System 8
(Date:9/17/2014)... at UTSouthwestern Medical Center have found that the most ... apoE3, helps repair the lining of blood vessels. Individuals ... benefit of this repair, putting them at higher risk ... identified one mechanism by which apoE3 promotes a healthy ... detrimental," said Dr. Philip Shaul , Professor of ...
(Date:9/17/2014)... decline, grasses have returned to some once-denuded patches of ... those places seems healthy again, but a new study ... coastal protection remains diminished. , "We,ve got ... back," said ecologist Mark Bertness, professor of biology at ... journal Biological Conservation . "The metric of a ...
(Date:9/17/2014)... United Kingdom forms a new crime unit designed to ... last year over horse meat being passed off as ... for detecting meat adulteration. They describe their approach, which ... Journal of Agricultural and Food Chemistry . , ... a major global economic problem. But they also say ...
Breaking Biology News(10 mins):Protein variant may boost cardiovascular risk by hindering blood vessel repair 2Cape Cod saltmarsh recovery looks good, falls short 2Cape Cod saltmarsh recovery looks good, falls short 3
... Like a kindergarten or a busy airport where cold ... places where pollinators such as bees and butterflies can pick ... benign as the sniffles or as debilitating as influenza. ... pollinators are transmitted at flowers," postdoctoral researcher Scott McArt and ...
... are more positive than negative now with regards to the ... way to go." Considerable progress has been made in ... continues to generate smoke from the open mine. Fire ... there are still "weeks of firefighting ahead" according to Craig ...
... New research from Plymouth State University and the ... horseshoe crabs for biomedical purposes causes short-term changes in ... population decline in parts of the east coast. ... blue blood from almost half a million living horseshoe ...
Cached Biology News:As hubs for bees and pollinators, flowers may be crucial in disease transmission 2Biomedical bleeding affects horseshoe crab behavior 2Biomedical bleeding affects horseshoe crab behavior 3
... 2000 instrument can be used as a ... Data Manager Software provides the means to ... the instrument. These data can then be ... such as Microsoft Excel or Lotus 123, ...
... Gasket slide kit (1x 22K gasket/slide) G2534-60003 ... or Gasket slide kit (2x 11K ... slides offered in either 11K or 22K microarray feature ... gaskets are carefully fabricated and batch tested to ensure ...
... is a new product number, ... product number. If showing no ... the old Sigma-Aldrich number (Z71,346-5) ... assistance. ID clarifier: box holds ...
... description: self locking design in ice/water ... new product number, created to easily ... no availability yet, please order under ... contact customer service for assistance. ID ...
Biology Products: