Navigation Links
Researchers use genomics to investigate TB outbreak
Date:2/25/2011

Vancouver, BC - Scientists supported by Genome BC have set a new standard for studying outbreaks of infectious disease by combining advanced genomics with a detailed map of the social relationships between cases to investigate a recent outbreak of tuberculosis in a BC community.

The study tracked 41 individuals who developed tuberculosis: patient interviews revealed a tightly-knit community where most patients knew one another, while DNA fingerprinting of the bacterial samples from each individual showed them to be identical to each other. These two factors together made reconstructing the outbreak family tree impossible.

In order to get a more detailed picture of how TB spread through the community, researchers from the BC Centre for Disease Control (BCCDC), Canada's Michael Smith Genome Sciences Centre and Simon Fraser University turned to whole genome sequencing to discern subtle genetic differences between different bacterial strains. These slight differences allowed them to identify individual transmission events, in which one patient can be identified as the most likely source of the subsequent patient's infection. By looking at all of the transmission events revealed by the data, the researchers were able to identify not only where the outbreak organism had originated, but also how it had moved throughout the community.

"Genome sequencing used to be prohibitively expensive, so it was simply impossible to sequence the bacteria from all the patients involved in an outbreak and we had to go with the next best thing, DNA fingerprinting," says Dr. Jennifer Gardy at the BCCDC. "Now, however, sequencing tens, hundreds, or thousands of bacterial isolates is very doable in a reasonable timeframe and at a manageable cost. We can figure out how these bacteria are related to each other by comparing their genome sequences, and when we overlay that information onto a map of the social relationships between cases we can actually reconstruct the path by which an infectious agent worked its way through a population."

Understanding how an organism enters and spreads through a population is key to public health efforts to manage an outbreak and prevent future cases. This particular study revealed that rather than chains of transmission, in which one person infects another who then infects another and so on, this outbreak was the result of bursts of transmission, where some individuals infected several contacts and others infected none. Knowledge of patterns like this can be used to identify which individuals in a community or in an outbreak should be proactively screened for disease and treated promptly if they test positive thereby mitigating the incidence of these bursts of infection.

"Our findings are already starting to influence how we investigate other TB outbreaks and how we're screening people who might be at risk for developing TB," says Gardy. "We've been able to take our study's findings and put them into practice right away."

"Being able to fund this timely and critical research is what makes Genome BC unique and in this instance, assisting outside of our traditional programs had a significant public impact. Genomics technology was crucial to the success of this study and reflects the value it can lend to public health in a larger context," says Dr. Alan Winter, President and CEO of Genome BC.

The BC researchers' findings have caught the eye of the wider medical community their findings will be published in the February 24th issue of the prestigious New England Journal of Medicine.


'/>"/>

Contact: Jenny Boon
jboon@genomebc.ca
778-327-8374
Genome BC
Source:Eurekalert

Related biology technology :

1. Quantum hot potato: NIST researchers entice 2 atoms to swap smallest energy units
2. Researchers get a grip on nervous systems receptors
3. Researchers at Harvard and MITRE produce worlds first programmable nanoprocessor
4. Size of airborne flu virus impacts risk, Virginia Tech researchers say
5. What a ride! Researchers take molecules for a spin
6. Practice Fusion Invites Health Researchers to Analyze This! Contest on Windows Azure
7. Columbia University researchers use nanoscale transistors to study single-molecule interactions
8. Researchers visualize herpes virus tactical maneuver
9. Thomson Reuters and ChemAxon Partner to Help Speed Drug Discovery for Life Science Researchers
10. Strange new twist: Berkeley researchers discover Möbius symmetry in metamaterials
11. Rice researchers take molecules temperature
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2017)... (PRWEB) , ... May 22, 2017 , ... ... joined with other leaders of the Maryland Biohealth community in developing and issuing ... recognized Top 3 U.S. BioHealth Innovation Hub by 2023. , ...
(Date:5/19/2017)... ... May 19, 2017 , ... In response to the strong base ... Medical Systems, Inc. announces the release of their Gait Trainer 3 with an Integrated ... a biomedical system to aid in rehabilitating individuals with cerebral palsy, traumatic brain injury, ...
(Date:5/18/2017)... ... 2017 , ... Clinical Supplies Management (“CSM”), a Great Point Partners II (“GPP”) ... CSM has doubled in size over the past six months with the acquisition ... Roger Gasper joins CSM as Chief Financial Officer. Roger has over 25 years ...
(Date:5/18/2017)... ... May 17, 2017 , ... ... process optimization firm for the life sciences and healthcare industries, is honored that ... Traceability for Medical Devices conference in Brussels, Belgium. , Crowley played a crucial ...
Breaking Biology Technology:
(Date:4/5/2017)... , April 4, 2017 KEY FINDINGS ... to expand at a CAGR of 25.76% during the ... is the primary factor for the growth of the ... https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The global stem ... technology, application, and geography. The stem cell market of ...
(Date:4/3/2017)...  Data captured by IsoCode, IsoPlexis Corporation,s ... statistically significant association between the potency of ... objective response of cancer patients post-treatment. The ... cancer patients will respond to CAR-T cell ... to improve both pre-infusion potency testing and cell ...
(Date:3/30/2017)... KONG , March 30, 2017 The ... a system for three-dimensional (3D) fingerprint identification by adopting ground breaking ... into a new realm of speed and accuracy for use in ... at an affordable cost. ... ...
Breaking Biology News(10 mins):