Navigation Links
Researchers turn viruses into molecular Legos
Date:10/19/2011

s how such a simple building block can create such complicated structures with diverse functions."

The researchers began by studying the factors influencing the formation of hierarchical structures.

"We noticed how collagen is secreted in confined spaces, and how its assembly into tissues can be influenced by its environment," said study lead author Woo-Jae Chung, a post-doctoral researcher in Lee's lab. "Unfortunately, collagen is a difficult material to study because it is hard to tune its physical and chemical structures. We needed a convenient model system to solve this problem."

That system was a soup of saline solution containing varying concentrations of a common bacteria-attacking virus, the M13 bacteriophage. The researchers chose the M13 virus harmless to humans and a model organism in research labs because its long, "chopstick-like" shape with a helical groove on its surface closely resembles collagen fibers.

The technique the scientists developed entails dipping a flat sheet of glass into the viral bath, then slowly pulling it out at precise speeds. The sheet emerges with a fresh film of viruses attached to it. At a pulling rate ranging from 10-100 micrometers per minute, it could take 1-10 hours for an entire sheet to be processed.

By adjusting the concentration of viruses in the solution and the speed with which the glass is pulled, the researchers could control the liquid's viscosity, surface tension, and rate of evaporation during the film growth process. Those factors determined the type of pattern formed by the viruses. The researchers created three distinct film patterns using this technique.

With a relatively low viral concentration of up to 1.5 milligrams per milliliter, regularly spaced bands containing filaments oriented at 90 degree angles to each other were formed.

With a slower pulling rate came increased physical constraints to the movement and orientation of the viruses.
'/>"/>

Contact: Sarah Yang
scyang@berkeley.edu
510-643-7741
University of California - Berkeley
Source:Eurekalert  

Page: 1 2 3

Related biology technology :

1. UBC researchers invent tiny artificial muscles with the strength, flexibility of elephant trunk
2. Notre Dame researchers awarded millions to develop radically new computers
3. 1 room -- 63 different dust particles? Researchers aim to build dust library
4. Mirage-effect helps researchers hide objects
5. Boston College Researchers discover 2 early stages of carbon nanotube growth
6. Researchers use carbon nanotubes to make solar cells affordable, flexible
7. Roche Researchers Sequence Complete Genome of Cynomolgus Monkey and Develop Novel Gene Expression Microarray for Drug Safety Assessment
8. Slippery slope:Researchers take advice from a carnivorous plant
9. University of Western Ontario researchers investigate stress and breast cancer
10. Rice researchers power line-voltage light bulb with nanotube wire
11. Stevens researchers pioneer novel technique to make plasmonic nanogap arrays
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers turn viruses into molecular Legos
(Date:12/24/2014)... , Dec. 23, 2014 Sigma-Aldrich ... that the waiting period under the Hart-Scott-Rodino Antitrust ... acquisition expired on December 22, 2014, thereby completing ... requirement for the acquisition of the Company by ... antitrust clearance satisfies another condition to closing the ...
(Date:12/24/2014)... and NEW YORK , Dec. ... its open-label pilot study of mazindol in children with ... and Therapy in December 2014 . ... in children with attention deficit/hyperactivity disorder" ( Konofal et ... 2014 Dec 1;8:2321-2332. eCollection 2014 ) shows that ...
(Date:12/22/2014)... ROCKVILLE, Md. , Dec. 22, 2014 ... MKT: SYN), a developer of pathogen-specific therapies ... focus on protecting the microbiome, today announced ... a Phase 1a clinical trial of SYN-004, ... the prevention of Clostridium difficile (C. ...
(Date:12/22/2014)... CHAPEL HILL, N.C. , Dec. 22, 2014 ... ALNE) today announced that it has signed a ... biotechnology company that has developed and patented a ... and medical diagnostics products that enable rapid on-site ... and alcohol use/abuse and health issues in an ...
Breaking Biology Technology:Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 2Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 3Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 2Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 3Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 2Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 3Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 4Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 5ALNE Announces Intention To Acquire BioTechPharma 2
... PAT and QbD remains a field that still lacks ... Pharma IQ across the PAT and QbD community it was  found ... not implementing PAT/QbD was due to a lack of personnel with ... opens its doors to industry specialists from the PAT and QbD ...
... Germany, October 11, 2011 joimax® opened ... patronage of the German Academy for Neurosurgery (GANS) and ... Neurosurgery at the "Städtisches Klinikum" in Karlsruhe, Prof. Dr. ... place in Karlsruhe, South Germany, October 5 to 8. ...
... Oct. 11, 2011 STAAR Surgical Company (NASDAQ: STAA ) ... quarter ended September 30, 2011 on Monday, October 24, 2011 ... will host a conference call on Monday, October 24, 2011 ... to discuss the Company,s third quarter results and recent corporate ...
Cached Biology Technology:Establishing the Correct QbD Strategies and Tools Early in the Development Process is Key to Ensuring we Have Robust Quality Products Downstream 2joimax® Inspires Thai-German Neurosurgery Congress Participants for TESSYS® 2joimax® Inspires Thai-German Neurosurgery Congress Participants for TESSYS® 3STAAR Surgical Announces Third Quarter 2011 Results Release Date and Conference Call 2
(Date:12/17/2014)... 15, 2014 Research and Markets ... the "Samsung Galaxy S5 - Home Button ... their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... sensing technology than the iPhone 5S, Samsung introduces ... its product. The Galaxy S5 home ...
(Date:12/17/2014)... 16, 2014 Valencell, a leader in performance ... technology to industry leaders such as Intel, Jabra, Atlas, ... biometric wearable products. These products will be showcased at ... Las Vegas . "Our partners ... and robust – with the clinical data to back ...
(Date:12/15/2014)... Dec. 12, 2014 Research and Markets ... of the "Global Facial Recognition Market 2015-2019" ... http://photos.prnewswire.com/prnh/20130307/600769 Facial recognition ... individuals. Facial recognition system measures the overall facial ... edges, mouth, and the distance between eyes. Facial ...
Breaking Biology News(10 mins):Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3
... Dec. 17, 2012 The University of Houston (UH) ... thanks to a computer hardware donation from Total, a ... nodes that will occupy four racks of space. ... computing resources," said Jaspal Subhlok, chairman of UH,s department ...
... December 2012)New research released today, on the eve of an ... agencies and investors for a growing spate of violent clashes ... of resources from the rural poor to investors is underway, ... Top global experts at the meeting noted as well that ...
... up on snack foods may increase cancer risk in ... cancers. Published early online in CANCER , a ... suggests that an eating pattern low in snack foods ... syndromelower their risk. Lynch syndrome is an inherited ...
Cached Biology News:Total donates high-speed computer cluster to UH 2New research predicts rising trend in India's Violent Land Conflicts; 130 districts struggle 2New research predicts rising trend in India's Violent Land Conflicts; 130 districts struggle 3New research predicts rising trend in India's Violent Land Conflicts; 130 districts struggle 4Snack attack: Eating unhealthy snack foods may affect cancer risk in patients with Lynch syndrome 2
...
...
SphingoStripsTM contain fifteen different biologically active, nitrocellulose-immobilized lipids at 100 pmol per spot, which can be assayed for protein binding and specificity using a simple blot ove...
The Discovery Series PDQuest 2-D analysis software is used for imaging, analyzing, and databasing two-dimensional electrophoretic gels. The version upgrade allows upgrade of an established version of...
Biology Products: