Navigation Links
Researchers reveal why some pain drugs become less effective over time
Date:4/3/2012

MONTREAL, April 3, 2012 Researchers at the University of Montreal's Sainte-Justine Hospital have identified how neural cells like those in our bodies are able to build up resistance to opioid pain drugs within hours. Humans have known about the usefulness of opioids, which are often harvested from poppy plants, for centuries, but we have very little insight into how they lose their effectiveness in the hours, days and weeks following the first dose. "Our study revealed cellular and molecular mechanisms within our bodies that enables us to develop resistance to this medication, or what scientists call drug tolerance," lead author Dr. Graciela Pineyro explained. "A better understanding of these mechanisms will enable us to design drugs that avoid tolerance and produce longer therapeutic responses."

The research team looked at how drug molecules would interact with molecules called "receptors" that exist in every cell in our body. Receptors, as the name would suggest, receive "signals" from the chemicals that they come into contact with, and the signals then cause the various cells to react in different ways. They sit on the cell wall, and wait for corresponding chemicals known as receptor ligands to interact with them. "Until now, scientists have believed that ligands acted as 'on- off' switches for these receptors, all of them producing the same kind of effect with variations in the magnitude of the response they elicit," Pineyro explained. "We now know that drugs that activate the same receptor do not always produce the same kind of effects in the body, as receptors do not always recognize drugs in the same way. Receptors will configure different drugs into specific signals that will have different effects on the body."

Pineyro is attempting to tease the "painkilling" function of opioids from the part that triggers mechanisms that enable tolerance to build up. "My laboratory and my work are mostly structured around rational drug design, and trying to define how drugs produce their desired and non desired effects, so as to avoid the second, Pineyro said. "If we can understand the chemical mechanisms by which drugs produce therapeutic and undesired side effects, we will be able to design better drugs."

Once activated by a drug, receptors move from the surface of the cell to its interior, and once they have completed this 'journey', they can either be destroyed or return to the surface and used again through a process known as "receptor recycling." By comparing two types of opioids DPDPE and SNC-80 the researchers found that the ligands that encouraged recycling produced less analgesic tolerance than those that didn't. "We propose that the development of opioid ligands that favour recycling could be away of producing longer-acting opioid analgesics," Pineyro said.


'/>"/>

Contact: William Raillant-Clark
w.raillant-clark@umontreal.ca
514-343-7593
University of Montreal
Source:Eurekalert

Related biology technology :

1. Researchers Identify New Regulator in Allergic Diseases
2. CNIO researchers take part in the most comprehensive personalized medicine study performed to date
3. Researchers develop graphene supercapacitor holding promise for portable electronics
4. Researchers capture first-ever images of atoms moving in a molecule
5. Penn researchers build first physical metatronic circuit
6. Pitt researchers coax gold into nanowires
7. York researchers create tornados inside electron microscopes
8. Self-assembling nanorods: Berkeley Lab researchers obtain 1-, 2- and 3-D nanorod arrays and networks
9. Navy researchers investigate small-scale autonomous planetary explorers
10. Notre Dame researchers develop paint-on solar cells
11. Quantum computing has applications in magnetic imaging, say Pitt researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/16/2017)... King of Prussia, PA (PRWEB) , ... August 16, 2017 , ... ... leaders will be taking part in sessions at the ISPE Annual Meeting and ... the Marriott Marquis San Diego Marina. The event’s theme is “Driving innovation to advance ...
(Date:8/16/2017)... , ... August 16, 2017 , ... While art and ... much more closely connected than one might think. A Mesh Is Also a ... at the University City Science Center’s Esther Klein Gallery (EKG) on August 17 and ...
(Date:8/16/2017)... Aug. 16, 2017  This year,s edition of the Inc. 5000 features ... sciences workforce solutions, has made the list for the third year in ... nation,s fastest-growing private companies based on a set of quantitative metrics. In ... the fastest-growing companies in the Bay State . ... Inc. 5000 ...
(Date:8/15/2017)... Charlotte, NC (PRWEB) , ... August 15, 2017 , ... ... in 2017, celebrating 10 years of successes helping medical technology companies and inventors develop ... company to a renowned full-service national engineering firm with a portfolio of clients in ...
Breaking Biology Technology:
(Date:4/4/2017)...   EyeLock LLC , a leader of iris-based ... Patent and Trademark Office (USPTO) has issued U.S. Patent ... an iris image with a face image acquired in ... 45 th issued patent. "The ... the multi-modal biometric capabilities that have recently come to ...
(Date:3/30/2017)... 30, 2017 The research team of The ... (3D) fingerprint identification by adopting ground breaking 3D fingerprint minutiae recovery ... of speed and accuracy for use in identification, crime investigation, immigration ... ... A research team ...
(Date:3/28/2017)... 2017 The report "Video Surveillance ... Servers, Storage Devices), Software (Video Analytics, VMS), and Service ... Forecast to 2022", published by MarketsandMarkets, the market was ... projected to reach USD 75.64 Billion by 2022, at ... base year considered for the study is 2016 and ...
Breaking Biology News(10 mins):