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Researchers outline structure of largest nonvirus particle ever crystallized
Date:11/26/2007

rotein chains each made of 873 amino acid residues folded into 14 domains. Each chain forms an elongated stave of half the vault, as well as the cap of the barrel-like shell.

"These nanostructured vaults offer a human-friendly nanocontainer, like a molecular-level C-5A transport jet, with a cargo hold large enough to encompass a whole ribosome with its hundreds of proteins and nucleic acids, or enough drugs to control a cell," Eisenberg said.

The construction of the draft atomic model lays the foundation for further studies of vaults and will guide vault engineering projects focused on the targeted release of vault contents for drug delivery.


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Contact: Jennifer Marcus
jmarcus@cnsi.ucla.edu
310-267-4839
University of California - Los Angeles  
Source:Eurekalert

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