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Researchers identify a gene that may play a key role in atherosclerosis and other diseases
Date:3/15/2010

f other stress-sensitive genes by HuR was not due to changes in mRNA stability by direct protein binding," explained Bao.

To uncover the pathways that lead to HuR's stress sensitivity, the researchers conducted a series of studies to reveal that HuR functions by adding a phosphate group to the transcriptional factor nuclear factor kappa B (NFkB) and its inhibitor IkBa. Additional research is underway to reveal what mRNAs HuR binds to and the mechanisms used to respond to mechanical and chemical stresses. Identifying the triggers for inflammation and unraveling the details of inflammatory pathways may eventually furnish new therapeutic targets.


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Contact: Abby Vogel
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Georgia Institute of Technology Research News
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