Navigation Links
Researchers identify a gene that may play a key role in atherosclerosis and other diseases
Date:3/15/2010

e responds to different flow environments and chemical treatments. They exposed human umbilical vein endothelial cells to disturbed flow -- which occurs in artery regions where plaques form -- and found that the cells expressed higher levels of HuR than when they experienced a static or laminar flow environment. This finding was validated in tissue experiments with results showing increased amounts of HuR in regions of a mouse aorta that were exposed to disturbed flow.

Then the researchers treated endothelial cells with statins, medications used to treat atherosclerosis by reducing the number of cholesterol-containing low-density lipoprotein (LDL) molecules in the blood and inhibiting inflammation. The results indicated a decreased level of HuR with statin treatment.

After establishing HuR as a stress-sensitive gene regulated by external stimuli, including flow and statin treatment, the researchers conducted experiments to determine whether HuR regulates the expression of other stress-sensitive genes. They found that reducing the level of HuR in cells increased the levels of two genes that combat atherosclerosis -- Kruppel-like factor 2 (Klf2) and endothelial nitric oxide synthase (eNOS). The reduction in HuR also decreased the expression of bone morphogenic protein-4 (BMP-4), a gene that supports atherosclerosis.

Reducing the level of HuR in cells also significantly inhibited many inflammatory responses of the endothelial cells, including the expression of two potential atherosclerosis drug targets: inter-cellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1).

Though this study showed that HuR plays a critical role in inducing and mediating an inflammatory response in cells subjected to a stressful environment, the underlying mechanism for this regulation is still not known.

"HuR protein often binds to messenger RNAs to increase their stability and translation, but we found that regulation o
'/>"/>

Contact: Abby Vogel
avogel@gatech.edu
404-385-3364
Georgia Institute of Technology Research News
Source:Eurekalert  

Page: 1 2 3

Related biology technology :

1. Researchers improve ability to write and store information on electronic devices
2. Long-awaited international ethical guidelines for biobank researchers
3. CU researchers shed light on light-emitting nanodevice
4. Stevens researchers provide new information about mass spectrometry
5. Researchers measure carbon nanotube interaction
6. Researchers underscore limitations of genetic ancestry tests
7. ASU researchers improve memory devices using nanotech
8. UD researchers race ahead with latest spintronics achievement
9. Researchers outline structure of largest nonvirus particle ever crystallized
10. Ames Laboratory researchers solve fuel-cell membrane structure conundrum
11. Researchers use magnetism to target cells to animal arteries
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers identify a gene that may play a key role in atherosclerosis and other diseases
(Date:7/10/2014)... 2014 OMICS Group’s 5th International conference ... August, 2014 at Double Tree by Hilton Beijing, China ... in Analytical & Bioanalytical research methods only to facilitate ... this occasion, Dr. Srinubabu Gedela, MD of OMICS Group ... a remarkable one in bringing a unique and international ...
(Date:7/10/2014)...  Kainos Capital, a firm specializing in acquiring and ... has acquired the Slim-Fast brand from Unilever. Unilever will ... the transaction were not disclosed. Slim-Fast is ... markets ready-to-drink shakes, powders, bars and snacks to retail ... in the United Kingdom and ...
(Date:7/10/2014)... may help in the fight against terrorism with the ... of explosives with the use of light and special ... and Actuators B: Chemical , the researchers describe a ... concentrations as low as 6.3 ppm (parts per million). ... minutes. , "Traditionally explosives detection has involved looking for ...
(Date:7/10/2014)... our laptops and electric vehicles could store more energy ... help of a sponge-like silicon material. , Researchers ... used in one of the battery,s electrodes, as silicon ... of graphite. A paper describing the material,s performance as ... Nature Communications . , "Silicon has long been sought ...
Breaking Biology Technology:A Critical Review of Analytical Techniques for Improved Living Standards 2A Critical Review of Analytical Techniques for Improved Living Standards 3A Critical Review of Analytical Techniques for Improved Living Standards 4Kainos Capital Acquires Slim-Fast From Unilever 2Detecting trace amounts of explosives with light 2Silicon sponge improves lithium-ion battery performance 2Silicon sponge improves lithium-ion battery performance 3
... Grow to $10.5 Million in 2007; MOXATAG, Company,s Lead, PULSYS ... ... Alternatives Ongoing, GERMANTOWN, Md., March 4 ... focused on,developing and commercializing novel anti-infective products, today,announced financial and ...
... LAS VEGAS, March 4 ,Cord Blood America, Inc. ... cell preservation company ( http://www.cordblood-america.com ),focused on ... to families,nationwide and internationally, today announced its wholly ... on car #49 at the Sunday, March 2, ...
... For centuries, engineers have bent and torn metals to ... the University of Pennsylvania School of Engineering and Applied ... sizes in the form of wires a thousand times ... Penn engineers to construct a theoretical model to predict ...
Cached Biology Technology:MiddleBrook Pharmaceuticals Reports Fourth Quarter and Full Year 2007 Results 2MiddleBrook Pharmaceuticals Reports Fourth Quarter and Full Year 2007 Results 3MiddleBrook Pharmaceuticals Reports Fourth Quarter and Full Year 2007 Results 4MiddleBrook Pharmaceuticals Reports Fourth Quarter and Full Year 2007 Results 5MiddleBrook Pharmaceuticals Reports Fourth Quarter and Full Year 2007 Results 6MiddleBrook Pharmaceuticals Reports Fourth Quarter and Full Year 2007 Results 7MiddleBrook Pharmaceuticals Reports Fourth Quarter and Full Year 2007 Results 8MiddleBrook Pharmaceuticals Reports Fourth Quarter and Full Year 2007 Results 9MiddleBrook Pharmaceuticals Reports Fourth Quarter and Full Year 2007 Results 10MiddleBrook Pharmaceuticals Reports Fourth Quarter and Full Year 2007 Results 11MiddleBrook Pharmaceuticals Reports Fourth Quarter and Full Year 2007 Results 12MiddleBrook Pharmaceuticals Reports Fourth Quarter and Full Year 2007 Results 13MiddleBrook Pharmaceuticals Reports Fourth Quarter and Full Year 2007 Results 14MiddleBrook Pharmaceuticals Reports Fourth Quarter and Full Year 2007 Results 15Cord Blood America Subsidiary Featured at NASCAR Sprint Cup Series Race 2Cord Blood America Subsidiary Featured at NASCAR Sprint Cup Series Race 3Surface dislocation nucleation: Strength is but skin deep at the nanoscale, Penn engineers discover 2
(Date:7/11/2014)... WASH. July 11, 2014 Researchers have ... three-dimensional images. The new technology, called Virtual Finger, ... small structures like neurons and synapses using the ... unique technology makes 3D imaging studies orders of ... at an unprecedented level across many areas of ...
(Date:7/11/2014)... that transplantation of mesenchymal stem cells can stimulate neurogenesis ... of Alzheimer,s disease (AD) and improve tissue and function ... are reported on the therapeutic effect of adipose-derived stem ... the effect on oxidative injury and neurogenesis in the ... team, School of Life Sciences, Tsinghua University, China transplanted ...
(Date:7/11/2014)... under the normal circumstances, astrocytes participate in ... environment, and exhibit therapeutic and repairing effects ... studies have found that nerve cells differentiated ... have reduced viability, which produces influences on ... Kailuan General Hospital, Hebei United University, China ...
Breaking Biology News(10 mins):Virtual finger enables scientists to navigate and analyze complex 3D images 2
... suffer severe burns. The resulting large, deep wounds caused by ... is needed to reduce this kind of scarring is the ... of skin can be removed from the individual patient as ... grafting, another option is to engineer a skin graft in ...
... centres in synthetic biology will be established in ... to funding from the Biotechnology and Biological Sciences ... Sciences Research Council (EPSRC). The 40M+ investment ... and Science David Willetts tonight at a BBSRC ...
... have had bariatric surgery may need to take dietary ... a UT Southwestern Medical Center study suggests. The ... , tracked a group of gastric banding patients and ... most still did not meet recommended daily requirements for ...
Cached Biology News:Blood and lymphatic capillaries grown for the first time in the lab 2UK establishes 3 new synthetic biology research centers 2Gastric banding patients should closely monitor nutrition following surgery 2Gastric banding patients should closely monitor nutrition following surgery 3