Navigation Links
Researchers identify a gene that may play a key role in atherosclerosis and other diseases
Date:3/15/2010

To understand the role of inflammation in cardiovascular and other diseases, it is essential to identify and characterize genes that induce an inflammatory response in the body -- and the genes that regulate them.

A study published online this week in the journal Proceedings of the National Academy of Sciences suggests that a gene called Hu antigen R (HuR) plays a critical role in inducing and mediating an inflammatory response in cells experiencing mechanical and chemical stresses. The study was supported by the National Institutes of Health.

The findings may open up new possibilities for developing treatments of metabolic diseases associated with inflammation, such as atherosclerosis. Atherosclerosis typically occurs in branched or curved regions of arteries where plaques form because of cholesterol build-up. Inflammation can alter the structure of plaques so that they become more likely to rupture, causing a blood vessel blockage and leading to heart attack or stroke.

"This is the first systematic study showing that HuR not only responds to external stimuli as a stress-sensitive gene, but it also regulates other stress-sensitive genes," said senior author Gang Bao, the Robert A. Milton Chair in Biomedical Engineering in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University.

The study results show that HuR promotes the expression of genes that support atherosclerosis and inhibits the expression of genes that combat atherosclerosis.

"We found that suppressing expression of HuR inhibited the inflammatory response of cells, which shows that designing drugs that block HuR function may reduce the risk of plaques rupturing," explained Bao.

Bao guided Won Jong Rhee, a former postdoctoral fellow in his laboratory, to conduct a series of experiments investigating the biology, behavior and pathways of HuR.

The researchers first studied how the HuR gen
'/>"/>

Contact: Abby Vogel
avogel@gatech.edu
404-385-3364
Georgia Institute of Technology Research News
Source:Eurekalert  

Page: 1 2 3

Related biology technology :

1. Researchers improve ability to write and store information on electronic devices
2. Long-awaited international ethical guidelines for biobank researchers
3. CU researchers shed light on light-emitting nanodevice
4. Stevens researchers provide new information about mass spectrometry
5. Researchers measure carbon nanotube interaction
6. Researchers underscore limitations of genetic ancestry tests
7. ASU researchers improve memory devices using nanotech
8. UD researchers race ahead with latest spintronics achievement
9. Researchers outline structure of largest nonvirus particle ever crystallized
10. Ames Laboratory researchers solve fuel-cell membrane structure conundrum
11. Researchers use magnetism to target cells to animal arteries
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers identify a gene that may play a key role in atherosclerosis and other diseases
(Date:9/16/2014)... , Sept. 16, 2014  Biocom, the association ... science community, recognizes the 9 th Annual National ... value of IT technologies in improving our health care ... is one of the world,s most vibrant hubs ... to mobile health applications to genomic testing to remote ...
(Date:9/16/2014)... COLUMBIA, Mo. From cell phones to cars ... everyday life. Scientists and technology companies constantly are ... Now, for the first time using a water-based ... created a long-lasting and more efficient nuclear battery ... as a reliable energy source in automobiles and ...
(Date:9/16/2014)... (PRWEB) September 16, 2014 ... world’s most efficient method for delivering dissolved gases ... Equipment Inc. as a manufacturer’s representative firm ... gas dissolution products for municipal water and wastewater ... Quebec. , H2Flow was founded in 1992 and ...
(Date:9/16/2014)... , Sept. 16, 2014  Donald Fresne, President and ... of Stephan Vagner , PhD to its Scientific Advisory ... of Toulouse, France , performed research at ... , and at Inserm, the French institute of health and ... works both at the Curie Institute, Orsay, France ...
Breaking Biology Technology:Biocom Recognizes National Health IT Week 2BlueInGreen® Expands into Canada – Signs Representative Agreement with H2Flow Equipment Inc. 2New Appointment to the Scientific Advisory Committee at Egenix, Inc. 2
... Gen-Probe Incorporated,(Nasdaq: GPRO ) announced today that the ... Conference on May 1, 2008 at,approximately 4:20 p.m. Eastern ... may be accessed through a link on the investors ... will be,available for 30 days following the event., ...
... Mass., April 24 Idenix,Pharmaceuticals, Inc. (Nasdaq: ... a corporate overview at the upcoming Morgan Stanley ... at 3:00 p.m.,ET at The Ritz Carlton in ... webcast of the company presentation can be,accessed under ...
... Commission Expected by Mid-2008, COLLEGEVILLE, Pa. ... Pharmaceuticals, a division of Wyeth (NYSE: ... PGNX ), today announced that the companies,have ... subcutaneous injection from the Committee for Medicinal ...
Cached Biology Technology:Gen-Probe to Webcast Presentation at Morgan Stanley Global Healthcare Unplugged Conference 2Wyeth and Progenics Receive Positive Opinion From European Committee for RELISTOR for the Treatment of Opioid-Induced Constipation in Advanced-Illness Patients 2Wyeth and Progenics Receive Positive Opinion From European Committee for RELISTOR for the Treatment of Opioid-Induced Constipation in Advanced-Illness Patients 3Wyeth and Progenics Receive Positive Opinion From European Committee for RELISTOR for the Treatment of Opioid-Induced Constipation in Advanced-Illness Patients 4Wyeth and Progenics Receive Positive Opinion From European Committee for RELISTOR for the Treatment of Opioid-Induced Constipation in Advanced-Illness Patients 5
(Date:9/17/2014)... State,s Institute for the Arts and Humanities has received ... for a two-year project, "The Boundaries of the Human ... project will support a wide-ranging series of events aimed ... humanities. One involves artists and researchers who are exploring ... the idea of humanism, and the other involves the ...
(Date:9/17/2014)... has developed, very cleverly, some lessons on how to ... said Joseph Shaw, director of the Optical Technology Center ... structures at the nanoscale, we,ll discover them." , Some ... August during a conference called "The Nature of Light: ... of the University of Arizona College of Optical Sciences. ...
(Date:9/17/2014)... A team of Spanish researchers have obtained the first ... a sixteenth century pig found at the site of ... that this ancient pig is closely related to today,s ... pigs were crossed with modern Iberian pigs. , The ... on evolutionary aspects of pig species, and particularly on ...
Breaking Biology News(10 mins):Mellon Foundation awards grant for major project in the humanities and sciences 2Nature's designs inspire research into new light-based technologies 2Nature's designs inspire research into new light-based technologies 3Iberian pig genome remains unchanged after 5 centuries 2
... mechanism has been discovered in a microorganism that thrives in ... key processes in human cells, and in a better understanding ... study is published today in the online version the American ... group at the Department of Molecular Evolution at Uppsala University ...
... innate defence system against deadly bacteria. However, how the step ... not yet known. To date, B. Pseudomallei, a ... can remain hidden in the human body for many years ... suddenly become activated and spread throughout the body, resulting in ...
... Measures to tackle the human impact on biodiversity ... countries working with common goals and frameworks. This ... European Science Foundation (ESF), which moved towards establishing ... and biodiversity analysis on the back of existing ...
Cached Biology News:New cell division mechanism discovered 2European biodiversity and ecosystem scientists merge and gear up for long-term research 2
... C1 Plus is a modular confocal system ... with an ultra-compact and lightweight design. The ... Plusboost optical performance to 400nm andits bi-directional ... support for X and Y scan axes ...
... integrated digital microscope and camera system that ... optical adjustment or software installation. Built on ... combines simplicity and advanced technology for users ... viewing of a macro image and a ...
... The TUNEL-based assay kit provides complete ... cells for convenient detection of DNA ... sections. The incorporation of BrdU in ... biotinylated or digoxigenylated methods. Results can ...
... The Fujifilm Life Science LAS-3000 ... technology with a simplified user interface, ... a wide range of modularities. The ... applications, and the perfect standard system ...
Biology Products: