Navigation Links
Researchers gain detailed insight into failing heart cells using new nano technique
Date:2/25/2010

ound that the beta2AR receptors are normally anchored in the t-tubules, but in those cells damaged by heart failure they change location and move into the same space as beta1AR receptors. The researchers believe that this altered distribution of receptors might affect the beta2AR receptors' ability to protect cells, and lead to more rapid degeneration of the failing heart.

One of the most important categories of drugs for slowing the development of heart failure are the beta-blockers, which prevent adrenaline from affecting the heart cells by targeting the beta receptors. The new finding increases understanding of what happens to the two receptors in heart failure and could lead to the design of improved beta-blockers. It may eventually help resolve an existing debate about whether it is better to block the beta2AR receptors as well as the beta1AR.

Dr Julia Gorelik, corresponding author of the study from the National Heart and Lung Institute at Imperial College London, said: "Our new technique means we can get a real insight into how individual cells are disrupted by heart failure. Using our new nanoscale live-cell microscopy we can scan the surface of heart muscle cells to much greater accuracy than has been possible before and to see tiny structures that affect how the cells function.

"Through understanding what's happening on this tiny scale, we can ultimately build up a really detailed picture of what's happening to the heart during heart failure and long term, this should help us to tackle the disease. The main question for our future research will be to understand whether drugs can prevent the beta2-AR from moving in the cell and how this might help us to fight heart failure," added Dr Gorelik.

For the study, the researchers looked at single living cardiac muscle cells in a culture dish, taken from healthy or failing rat hearts. They stimulated the beta1AR and beta2AR receptors using drugs applied via nanopipette inside th
'/>"/>

Contact: Laura Gallagher
l.gallagher@imperial.ac.uk
44-020-759-48432
Imperial College London
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Researchers improve ability to write and store information on electronic devices
2. Long-awaited international ethical guidelines for biobank researchers
3. CU researchers shed light on light-emitting nanodevice
4. Stevens researchers provide new information about mass spectrometry
5. Researchers measure carbon nanotube interaction
6. Researchers underscore limitations of genetic ancestry tests
7. ASU researchers improve memory devices using nanotech
8. UD researchers race ahead with latest spintronics achievement
9. Researchers outline structure of largest nonvirus particle ever crystallized
10. Ames Laboratory researchers solve fuel-cell membrane structure conundrum
11. Researchers use magnetism to target cells to animal arteries
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... 2014 After the boom of the ... next beverage craze is going to be the stress ... can use Stress Relief energy pattern which can be ... of a beverage, including minerals, herbs and liquids. Stress ... that power into rapid recovery and helping to adapt ...
(Date:8/27/2014)... WriteResult, LLC – a premier provider of ePRO ... when it comes to meeting the needs of a ... their most recent study closeout on-time and with near ... writing platform to collect Patient Reported Outcomes electronically for ... data from a number of assessments including the IBS-Severity ...
(Date:8/26/2014)... -- NeuroSigma, Inc., a Los Angeles -based ... announced that it has filed a registration statement on ... relating to a proposed initial public offering of its ... and the price range for the proposed offering have ... act as the book-running manager for the proposed offering, ...
(Date:8/26/2014)... The 20 ambassadors representing the ALS ... issued the following statement on Facebook today regarding the ... new funding specifically for ALS research: , “Who would ... ice would raise all this awareness and funding toward ... on behalf of the entire ALS community, would like ...
Breaking Biology Technology:Stress Relief: 1 Way to De-Stress Your Beverage Formula 2Stress Relief: 1 Way to De-Stress Your Beverage Formula 3Stress Relief: 1 Way to De-Stress Your Beverage Formula 4A Perfect Record: WriteResult Maintains a 100% On-Time ePRO Record with Latest Irritable Bowel (IBS) Study Data Lock 2ALS TDI’s Young Faces of ALS Ambassadors Thank You for Accepting the Ice Bucket Challenge to End ALS 2ALS TDI’s Young Faces of ALS Ambassadors Thank You for Accepting the Ice Bucket Challenge to End ALS 3ALS TDI’s Young Faces of ALS Ambassadors Thank You for Accepting the Ice Bucket Challenge to End ALS 4
... Services Provided by Interleukin ... ... ,Interleukin Genetics, Inc. (Amex: ILI ), and OralDNA Labs, Inc., ... Genetics, proprietary PST(R) Genetic Test. The PST(R),Genetic Test provides a means ...
... Aug. 13 WaferGen Biosystems,Inc. (OTC Bulletin Board: ... cell biology and stem cell research systems,today highlighted ... results for the quarter and six months ended ... Milestones:, -- Initiation of alpha testing of ...
... Bio-Forge® product line through the use of its new interactive micro ... proprietary technology, plant growth cycles and hormone balance--the critical relationship that ... , ... Houston, TX (PRWEB) August 14, 2008 -- StollerUSA ...
Cached Biology Technology:Interleukin Genetics Licenses its PST(R) Genetic Test to OralDNA Labs 2Interleukin Genetics Licenses its PST(R) Genetic Test to OralDNA Labs 3Interleukin Genetics Licenses its PST(R) Genetic Test to OralDNA Labs 4WaferGen Announces Second Quarter 2008 Financial Results 2WaferGen Announces Second Quarter 2008 Financial Results 3WaferGen Announces Second Quarter 2008 Financial Results 4WaferGen Announces Second Quarter 2008 Financial Results 5WaferGen Announces Second Quarter 2008 Financial Results 6WaferGen Announces Second Quarter 2008 Financial Results 7WaferGen Announces Second Quarter 2008 Financial Results 8StollerUSA Launches Bio-Forge.com to Offer Solutions for Crops Under Stress 2StollerUSA Launches Bio-Forge.com to Offer Solutions for Crops Under Stress 3
(Date:8/27/2014)... that century-old museum specimens hold clues to how global climate ... and kill trees and the news is not good. ... oak and maple trees in warmer urban areas, which raises ... warming," says Dr. Elsa Youngsteadt, a research associate at NC ... , "More scale insects would be a problem, since scales ...
(Date:8/26/2014)... Scientists at the University of Warwick have provided ... naturally occurring protein is linked to early signs ... , the research found that the absence of ... to cells in the nervous system. These changes ... early signs of dementia, including restricted learning and ...
(Date:8/26/2014)... of a pen a New Zealand endemic tree has for ... a group of ,weedy, Australian shrubs and small trees. A ... some surprises and discover astonishing cryptic diversity behind what was ... in the open access journal PhytoKeys . ... species was one of the many discoveries made in the ...
Breaking Biology News(10 mins):Museum specimens, modern cities show how an insect pest will respond to climate change 2Lack of naturally occuring protein linked to dementia 2And then there were 10 -- unexpected diversity in New Zealand kanuka genus Kunzea 2And then there were 10 -- unexpected diversity in New Zealand kanuka genus Kunzea 3
... BLOOMINGTON, Ind. -- Two recently diverged populations of a ... contribute to the reproductive isolation that accompanies the origin ... of organic compounds present in the preen oils of ... Ecology . "There,s so much we don,t know ...
... Age and gender play a major role in how ... 20-to-64-year-olds. Published in the journal Psychophysiology , the investigation ... the Montreal Heart Institute in collaboration with colleagues from the ... findings suggest that women who are more defensive are at ...
... University of Western Ontario finds the sauces you use when ... benefits. The research, led by Western biology and psychology ... than just tasty sauces they can also provide a ... Mark Bernards and Christopher Guglielmo in Western,s department of biology. ...
Cached Biology News:Could smell play a role in the origin of new bird species? 2Could smell play a role in the origin of new bird species? 3Men and women respond differently to stress 2Spice up your health this barbecue season 2
... software for JASCO HPLC systems. , Integrated Instrument Control ... EZChrom Elite can ... JASCO HPLC systems. This provides a completely integrated system to control ... each run. , ...
... Gel loading solution, ... for non-denaturing polyacrylamide and ... nucleic acids and offers ... tracking dyes (bromphenol blue ...
Rabbit polyclonal to QKI...
... Introducing SilverSNAP Stain for Mass Spectrometry ... proteome, mass spectrometry (MS) has emerged as ... Silver staining of 2-D gels is now ... of procedures that leads ultimately to identification ...
Biology Products: