Navigation Links
Researchers at the University of Georgia Discover Protein is Crucial to Reproduction of Parasites Involved in Disease
Date:2/12/2009

s crucial to progress in understanding how these disease processes evolve."

Toxoplasma parasites replicate by dividing into two new parasites. Each new parasite requires a new apicoplast that must divide in synchrony with the parasite. What the team showed is that a protein called DrpA is crucial to the division of the apicoplast.

DrpA belongs to a family of proteins called dynamins, which are involved in a range of cellular processes that require constriction or pinching. Tracking the evolution of dynamins, the current work suggests that cells have the ability to retool these proteins to perform novel tasks, in this case to divide the symbiotic alga that was the ancestor of the apicoplast.

The group generated a mutant cell line to disrupt DrpA function in T. gondii. Using modern genetic and microscopy techniques, they showed that when the DrpA protein is no longer functional, the apicoplast can't pinch in two, preventing new parasites from acquiring this essential organelle. It results in the death of the parasite.

"Understanding that DrpA is necessary for apicoplast fission gives researchers a new working model to understand how the causative agents of several parasitic diseases flourish in human and animal hosts," said van Dooren.

Indeed, the team's search for similar dynamin-related proteins led them to examine, in addition to T. gondii, the genomes of four other parasitic organisms.

"In each, including Plasmodium, the cause of malaria, we found the DrpA protein, suggesting a common mechanism for apicoplast division in these parasites," said Striepen.

The new system now allows researchers to study what happens when organisms lose their apicoplast organelles.

###

Read the full story at http://www.prweb.com/releases/Toxoplasmosis/Cellular_Biology/prweb2041024.htm.


'/>"/>
Source: PRWeb
Copyright©2009 Vocus, Inc.
All rights reserved

Page: 1 2 3

Related biology technology :

1. FDA Approves Clinical Studies of a Novel Anti-Cancer Drug Developed by Italian Researchers
2. In Analyst Interview, Cord Blood America Says Stem Cells Now Front and Center for Researchers and Investors
3. Researchers: Molecular forklifts overcome obstacle to smart dust
4. Researchers control the assembly of nanobristles into helical clusters
5. Researchers measure elusive repulsive force from quantum fluctuations
6. USC researchers derive first embryonic stem cells from rats
7. Clemson researchers advance nanoscale electromechanical sensors
8. Duke researchers coax bright white light from unexpected source
9. Pitt researchers create nontoxic clean-up method for potentially toxic nano materials
10. USC researchers print dense lattice of transparent nanotube transistors on flexible base
11. J. Craig Venter Institute Researchers Publish Significant Advance in Genome Assembly Technology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... “Preparative & Process Chromatography Market by ... Solvents, Buffers, Valves, Guages, Seals), Accessories, Services, End ... to 2019” provides a detailed overview of the ... and strategies impacting the preparative and process chromatography ... the revenue and share analysis. , Full ...
(Date:12/24/2014)... 2014 SoundConnect’s ... to introduce cutting edge communication technology, provide ... of platform upgrades. This webinar series demonstrates ... in their quest to leverage web conferencing’s ... to SoundConnect’s Marketing Manager, Seanna Baumgartner, “Our ...
(Date:12/24/2014)... (PRWEB) December 23, 2014 ... mercaptan such as its definition, classification, application ... product specification, manufacturing process, and product cost ... and applications. The analysis also covers upstream ... channels, industry development trend and proposals. In ...
(Date:12/24/2014)... CA (PRWEB) December 23, 2014 Pipette.com ... where their Twitter followers can submit their #HolidayInTheLab pictures ... and their lab mates. , For those struggling to ... mates, the Pipette.com Holiday in the Lab Contest provides ... Pipette.com Twitter followers to send pictures of their ...
Breaking Biology Technology:Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3Worldwide Methyl Mercaptan Market 2015-2020 Forecasts on Development & Trends Now Available at ReportsnReports.com 2Major Pipette Distributor Pipette.com Announces their Holiday in the Lab Contest 2
... Inc. today announced that data from its phase 1/2 ... be highlighted in an oral presentation at the 50th ... in San Francisco, California, on December 9, 2008. , ... of the XIAP Antisense Oligonucleotide (AEG35156) in Combination with ...
... BioMarin Pharmaceutical,Inc. (Nasdaq: BMRN ) today announced that ... update at the Piper,Jaffray Healthcare Conference in New York City ... Interested parties may access a ... of the BioMarin website, http://www.BMRN.com . A,replay of the ...
... JOLLA, Calif., Nov. 25 TorreyPines Therapeutics, Inc.,(Nasdaq: ... from Eli Lilly & Company,a reduction in certain royalty ... sales of TorreyPines, clinical-stage compounds NGX426 and tezampanel,should either ... rate will be reduced three percentage points and the ...
Cached Biology Technology:Aegera Therapeutics' phase 1/2 clinical trial results selected for oral presentation at 2008 ASH Annual Meeting 2Aegera Therapeutics' phase 1/2 clinical trial results selected for oral presentation at 2008 ASH Annual Meeting 3BioMarin to Present at the Piper Jaffray Healthcare Conference 2TorreyPines Therapeutics Enters into Agreement to Reduce Royalty Rates and Delay Clinical Milestone Payments Due to Eli Lilly for NGX426 and Tezampanel 2
(Date:12/11/2014)... , Dec. 10, 2014  Data Sciences International ... has released a new series of digital telemetry ... toxicology researchers. M series, part of the PhysioTel™ ... the best possible physiologic data when incorporating functional ... functional endpoints to toxicology studies has evolved from ...
(Date:12/10/2014)... -- Valencell, a leader in performance biometric data sensor technology, ... its licensees for highly accurate, clinically validated biometric technology. ... from fitness and health sectors, but first responders/military and ... only as useful as the biometric data it delivers. ... long-term mass consumer adoption of wearable products," said Dr. ...
(Date:12/10/2014)... 9, 2014 CIE San Diego has launched ... the connective tissue that enhances care coordination among social ... share client-level information; earned a second $1 million grant ... serving seniors aging in community and; will be recognized ... 11 th 4-6p. CIE San Diego ...
Breaking Biology News(10 mins):New telemetry implants expected to change how large animal toxicology studies are conducted 2Wearable Technology Products Demand Highly Accurate Biometric Technology 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4
... "Net energy is a (mostly) irrelevant, misleading and dangerous ... Bioresources and Biorefining (Biofpr) in the latest issue ... a metric by which some scientists attempt to assess ... fossil fuel but recent debate in Biofpr shows that ...
... NASCAR, competitors and fans know that speed is only part ... elements like aerodynamic drafting, which makes it easier to follow ... -- is also critical. But in some cases, drafting ... experiences reduced drag, while the followers encounter more resistance -- ...
... University scientists concerned about lethal mold infections have found a ... gene, called srbA, allows molds to thrive during infections even ... author of a paper published in the Nov. 7 issue ... the mold becomes much more vulnerable to lack of oxygen ...
Cached Biology News:Scientific community called upon to resolve debate on 'net energy' once and for all 2Following the leader can be a drag, according to student's research on flapping flags 2Montana State University researchers find gene that regulates mold's resistance to drugs 2
Mouse monoclonal [B314.1 (MAC 387)] to Macrophage L1 protein Calprotectin (rating: ****) ( Abpromise for all tested applications)....
MOUSE ANTI HUMAN CYTOKERATIN 1-8...
Request Info...
... Polyoxyethylene Lauryl Ether 30% ... Kathon Preservative. Surfactant. Clear ... immunohistochemistry is 1 mL ... solution added to 400 ...
Biology Products: