Navigation Links
Researchers advance toward engineering 'wildly new genome'
Date:10/19/2013

ore, incorporating rare, non-standard amino acids could ensure strains only survive in a laboratory environment.

Engineering and evolution

Since a single genetic flaw can spell death for an organism, the challenge of managing a series of hundreds of specific changes was daunting, the researchers said. In both projects, the researchers paid particular attention to developing a methodical approach to planning and implementing changes and troubleshooting the results.

"We wanted to develop the ability to efficiently build the desired genome and to very quickly identify any problemsfrom design flaws or from undesired mutations and develop workarounds," Lajoie said.

The team relied on number oftechnologies developed in the Church lab and the Wyss Institute and with partners in academia and industry, including next-generation sequencing tools, DNA synthesis on a chip, and MAGE and CAGE genome editing tools. But one of the most important tools they used was the power of natural selection, the researchers added.

"When an engineering team designs a new cellphone, it's a huge investment of time and money. They really want that cell phone to work," Church said. "With E. coli we can make a few billion prototypes with many different genomes, and let the best strain win. That's the awesome power of evolution."


'/>"/>

Contact: David Cameron
david_cameron@hms.harvard.edu
617-432-0441
Harvard Medical School
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. New England Biolabs Introduces Polbase, an Information Repository of Scientific Data for Polymerase Researchers
2. In new quantum-dot LED design, researchers turn troublesome molecules to their advantage
3. Multidisciplinary team of researchers develop world’s lightest material
4. Researchers shrink tumors and minimize side effects using tumor-homing peptide to deliver treatment
5. Innovative MetaMorph® NX Software Shatters Barriers Between Researchers and Image Analysis Goals with Exclusive Visual Workflow
6. UCLA researchers demonstrate fully printed carbon nanotube transistor circuits for displays
7. Penn and Brown researchers demonstrate earthquake friction effect at the nanoscale
8. Two Top Biological Imaging Centers Offer Powerful Free Online Tool to Researchers, Educators, and Public
9. Researchers develop one of the worlds smallest electronic circuits
10. MU researchers identify key plant immune response in fight against bacteria
11. Researchers realize high-power, narrowband terahertz source at room temperature
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2015)... NEW YORK , April 17, 2015  Guggenheim ... Guggenheim Partners, today announced the hiring of William ... research analyst. Mr. Tanner will start work ... New York office. "Bill ... and academic research, to our experienced and highly acclaimed ...
(Date:4/16/2015)... Carolina (PRWEB) April 17, 2015 ... steam system services, released their newly designed, state-of-the-art ... The customer facing website effectively promotes the Spirax ... , All the information that a site visitor ... system services, company capabilities, industries serviced, the latest ...
(Date:4/16/2015)... Irvine, CA (PRWEB) April 16, 2015 ... in the Buzz of BIO Contest for ... Industry Organization (BIO), the 2015 BIO International Convention will ... in Philadelphia, Pennsylvania. During the Buzz of BIO contest, ... like to see present at the conference. The community ...
(Date:4/16/2015)... The Council for Agricultural Science ... Borlaug CAST Communication Award goes to Dr. Channapatna ... in Alabama. Award nominees must demonstrate an ability ... the use of television, radio, or other social ... a specialist in the field of plant genetics ...
Breaking Biology Technology:Guggenheim Securities Hires Biotech Analyst William Tanner in Expansion of Healthcare Coverage 2Spirax Sarco website has a new look 2Proove Bisociences to Participate in the Buzz of BIO at the 2015 BIO International Convention 2Proove Bisociences to Participate in the Buzz of BIO at the 2015 BIO International Convention 3The 2015 Borlaug CAST Communication Award Goes to Channapatna Prakash 2
... ... San Diego, CA (PRWEB) December 3, ... based on the products of newborn fibroblasts, announced today that ... Officer. Gollamudi,s business and product development expertise will be invaluable ...
... Iceland, Dec. 3 ,HemoGenix(R) and ORF Genetics announce ... and cytokines for use in all HALO(R),Assay Kits ... of human,blood-forming cells is detected. , ... large number of growth factors and cytokines using,barley ...
... Rigel,Pharmaceuticals, Inc. (Nasdaq: RIGL ) today announced ... call with simultaneous webcast,on Sunday, December 7, 2008, at 4:00 ... trial of R788, an oral Syk kinase inhibitor, in,patients with ... Conference Call and Webcast Information , ...
Cached Biology Technology:Histogen Welcomes Dr. Hyma Gollamudi as Chief Business Officer 2HemoGenix(R), Inc Announces Implementation of ORF Genetics Human Growth Factors and Cytokines in All Human HALO(R) Assay Kits and Contract Research Services 2HemoGenix(R), Inc Announces Implementation of ORF Genetics Human Growth Factors and Cytokines in All Human HALO(R) Assay Kits and Contract Research Services 3Rigel to Host Conference Call to Discuss Phase 2 Study Results of R788 in Lymphoma Presented at ASH 2
(Date:3/24/2015)... March 24, 2015   Crossmatch ™, a ... announced that its U.are.U ® 4500 Fingerprint ... Goorin Bros . to achieve PCI compliance for ... access to the POS terminal, protecting the retailer ... data breaches. With one-third of ...
(Date:3/23/2015)... 2015  In the 2014 fiscal year, irs.gov recorded ... This figure accounts for a fraction of the estimated ... Report, exceeds $11 billion globally. The polygraph has traditionally ... has occurred. Investor Mark Saint Juste along ... Paolella partnered to administer the test in a ...
(Date:3/20/2015)... , Mar. 19, 2015 Research and Markets ... "Hand Geometry - Global Strategic Business Report" report ... markets for Hand Geometry in US$ Thousands. The report provides ... , Japan , Europe ... , and Rest of World. Annual estimates ...
Breaking Biology News(10 mins):Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 2Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 4
... 25, 2008, approaching 5 p.m. PDT, NASA scientists will be ... at that time the Phoenix Mars Mission space vehicle will ... soft landing onto the northern Mars terrain called Green Valley. ... Red Planet. The place got its name after analysis of ...
... Angeles, London, New Delhi, and Singapore (April 14, 2008) ... consumption is not related to overweight in children, according ... Between 100% Fruit Juice Consumption and Weight in Children ... Journal of Lifestyle Medicine (AJLM), published by SAGE. ...
... cycle plays a major role in seagrass fields. ... of seagrasses in Indonesia. He discovered that the ... an efficient nitrogen cycle in tropical seagrass fields. ... retained. Seagrass fields are coastal ecosystems ...
Cached Biology News:Phoenix mission to Mars will search for climate clues 2Phoenix mission to Mars will search for climate clues 3New research: Fruit juice consumption not related to overweight in children 2Nitrogen retained through loss 2
RAT ANTI MOUSE TCR V BETA 7:RPE Immunogen: T-cell lymphoma TK1...
ANTI S. ENT TOX BC2D...
... Anti-Major DNA-binding protein(DBP). Protein size: ... NP_001343 ELISA titre using peptide ... conditions for Western Blot: 1.0g/ml ... and HRP conjugated anti-Rabbit IgG should be ...
Collected from sexually mature, mixed sex, mixed breed guinea pigs. Pricing: $120/unit for 1 - 10 units...
Biology Products: