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Researchers advance toward engineering 'wildly new genome'
Date:10/19/2013

ologically Inspired Engineering. Farren Isaacs, assistant professor of molecular, cellular, and developmental biology at Yale School of Medicine, is co-senior author on the first study.

Toward safer, more productive, more versatile biotech

Recoded genomes can confer protection against viruseswhich limit productivity in the biotech industryand help prevent the spread of potentially dangerous genetically engineered traits to wild organisms.

"In science we talk a lot about the 'what' and the 'how' of things, but in this case, the 'why' is very important," Church said, explaining how this project is part of an ongoing effort to improve the safety, productivity and flexibility of biotechnology.

"These results might also open a whole new chemical toolbox for biotech production," said Isaacs. "For example, adding durable polymers to a therapeutic molecule could allow it to function longer in the human bloodstream."

But to have such an impact, the researchers said, large swaths of the genome need to be changed all at once.

"If we make a few changes that make the microbe a little more resistant to a virus, the virus is going to compensate. It becomes a back and forth battle," Church said. "But if we take the microbe offline and make a whole bunch of changes, when we bring it back and show it to the virus, the virus is going to say 'I give up.' No amount of diversity in any reasonable natural virus population is going to be enough to compensate for this wildly new genome."

In the first study, with just a single codon removed, the genomically recoded organism showed increased resistance to viral infection. The same potential "wildly new genome" would make it impossible for engineered genes to escape into wild populations, Church said, because they would be incompatible with natural genomes. This could be of considerable benefit with strains engineered for drug or pesticide resistance, for example. What's m
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Contact: David Cameron
david_cameron@hms.harvard.edu
617-432-0441
Harvard Medical School
Source:Eurekalert

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