The gene that controls for plating is called Eda, which comes in two forms: one causes low plating and the other complete plating. Peichel was the first person to home in on the neighborhood where the Eda gene lives while a postdoctoral researcher in the laboratory of David Kingsley, Ph.D., at Stanford University.
In humans, mutations in this gene cause a syndrome called ectodermal dysplasia, a group of more than 100 inherited disorders that impact the ectoderm, the outer layer of tissue involved in the formation of many parts of the body, including the skin, nails, hair, teeth and sweat glands.
"There's probably a developmental correlation between these external structures in humans and the bony plates on the fish," Peichel said. "It also looks like the Eda gene was probably important for human evolution although we don't really know in what context," she said.
Collaborators on the study included researchers from the University of Washington in Seattle; the University of Texas in Austin; Gifu Keizai University in Ogaki, Gifu, Japan; and the Research Institute for Humanity and Nature in Kyoto, Japan. The work was supported by a Uehara Memorial Fellowship, the Packard Foundation, Seattle Public Utilities, Water and People Project, and a Burroughs Wellcome Fund Career Award in the Biomedical Sciences.
At Fred Hutchinson Cancer Research Center, our interdisciplinary teams
of world-renowned scientists and humanitarians wor
|SOURCE Fred Hutchinson Cancer Research Center|
Copyright©2008 PR Newswire.
All rights reserved