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Research Using Thermo Fisher Scientific RNA-Interference Technology Unveils Potential New Targets for HIV Drugs
Date:1/31/2008

irector of the HMS Division of AIDS. The team also included Dr. Abraham L. Brass, postdoctoral researcher, working with Derek Dykxhoorn and Nan Yan, molecular virologists in Dr. Lieberman's group. Brass used the Dharmacon siGENOME siRNA Library for discovering weaknesses in pathogens such as HIV.

"HIV only expresses a few proteins, so it depends greatly on our cellular machinery during its lifecycle," said Brass. "Every time the virus relies on one of our proteins, it gives us the potential to disrupt that interaction and hurt HIV, which is very exciting. We also now have the ability to combine technology like siRNA screening with advanced robotics, giving us an incredibly powerful tool to go after devastating diseases such as HIV and cancer."

Dr. Caroline Shamu, director of the ICCB-Longwood Screening Facility, added, "Whole-genome siRNA (short-interfering RNA) screening is playing an increasingly important role in advancing genomic and proteomic research. Because it allows us to investigate the entire human genome, screening thousands of samples simultaneously, it dramatically accelerates the pace of biomedical discovery." Shamu's facility hosts the Dharmacon siGENOME siRNA Library and oversees screening conducted by researchers from Harvard Medical School and its affiliates.

The siGENOME siRNA Library is a collection of more than 21,000 siRNAs targeting every gene in the human genome. Each siRNA silences or disrupts the gene's ability to produce a specific protein. The siGENOME siRNA Library is currently used by many of the world's leading research institutions to accelerate the identification of genes important to human health.

Harvard Medical School is a member of the RNAi Global Initiative, founded by the Dharmacon products team and several leading research institutions around the world. In addition to Thermo Fisher Scientific, there are now 26 member institutions, all using the siGENOME siRNA Library and collaborating on research i
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SOURCE Thermo Fisher Scientific Inc.
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