Navigation Links
Research Published in Nature Medicine Shows Disruption of Chemokine Interactions Inhibits Atherosclerosis in Mice
Date:1/5/2009

ytes (a type of white blood cell and part of the body's immune system) to the arterial wall, causing the inflammation that is characteristic of atherosclerosis.

The RWTH Aachen University scientists characterized the structure of the PF4-RANTES interactions using NMR spectroscopy and then designed a series of peptides to disrupt those interactions. One such peptide, termed CKEY2, is comprised of sequences from the RANTES protein. CKEY2 was shown to be stable and formed the secondary structural motif found in RANTES when stabilized by disulfide bridged cysteines at both ends of the peptide. The scientists demonstrated that CKEY2 disrupts PF4-RANTES heteromer formation by binding preferentially to RANTES. In vitro assays demonstrated that CKEY2 inhibited the recruitment of monocytes to endothelial cells. Finally, the scientists demonstrated that mice that are genetically predisposed to develop atherosclerosis when fed a high fat diet did not develop chronic arterial inflammation when injected with the mouse version of the CKEY2 peptide.

"With the efficacy of the PF4-RANTES inhibitor established in preclinical studies for atherosclerosis, we are expanding our work into pre-clinical studies in other inflammatory disease models," said Josh Schultz, Ph.D., Carolus Therapeutics' vice president of research. "Our ongoing collaboration with RWTH Aachen University involves the further exploration of chemokine interactions involved in inflammatory signaling."

In addition to targeting PF4-RANTES heterodimers, Carolus Therapeutics has a second drug discovery program targeting the pro-inflammatory cytokine MIF (Macrophage Migration Inhibitory Factor), which has emerged as a critical mediator of innate, cell-mediated immunity, immunoregulation and inflammation. Carolus Therapeutics' scientific founders previously identified two CXC chemokine receptors as novel functional receptors for MIF. Identification of structural moti
'/>"/>

SOURCE Carolus Therapeutics Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. Research Triangle Area Health Care Collaborative Launches Bridges to Excellence(R) Initiative to Improve Quality and Lower Costs
2. The Multiple Myeloma Research Consortium (MMRC) and Proteolix Initiate Phase 2 Clinical Trial Investigating Carfilzomib for the Treatment of Multiple Myeloma
3. BioMarin Licenses Technology From Leading Cystic Fibrosis Research Laboratory at the University of California, San Francisco
4. IDM Pharma Names Dr. Jeffrey W. Sherman Chief Medical Officer and Senior Vice President of Research and Development
5. Dawson James Securities Initiates Research Coverage on CryoCor, Inc. (Nasdaq: CRYO) with a Strong Buy Rating and $6.00 Target Price
6. eResearchTechnology to Present at the Thomas Weisel Healthcare Conference 2007 on September 5th
7. The Debiopharm Life Sciences Award Goes to Dr Nusser for his Outstanding Research in Neuroscience
8. Study Published in Clinical Cancer Research Confirms Potential Of Peregrines Bavituximab Combined With Radiation In Lung Cancer
9. Dow AgroSciences and Exelixis Plant Sciences Announce Major Research Collaboration, Asset Purchase to Advance Gene Discovery and Validation
10. Revolutionary Genomics Research Group Opens Boston Office; Provides DNA Evidence in Workers Comp Cases
11. Richard Schulz Receives the Coveted GCPj Award for Best Clinical Researcher of the Year
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... MA (PRWEB) December 18, 2014 LayerBio ... for ophthalmology and wound care. The National Eye Institute ... awarded LayerBio a Phase I SBIR grant to develop ... Cataracts are the most common cause of vision loss ... of blindness worldwide. According to Dr. Ken Mandell, LayerBio’s ...
(Date:12/19/2014)... (PRWEB) December 18, 2014 iLab Solutions, ... the appointment of Siri Bryant as the new Director ... Director of Core Implementations. These two new leadership positions ... customer service by ensuring that iLab continues to meet ... the last four years, iLab has been deployed at ...
(Date:12/19/2014)... December 18, 2014 With only 2 ... special on Sartorius Biohit products . The product ... pipettes, Picus Electronic Pipette Trade-in Program, and free pipette ... Safety officers around the world. They are ideal for ... features include:, ,     Full volume range of ...
(Date:12/19/2014)... Dec. 18, 2014   ISN has released ... Performance Indicators publication series. With data aggregated ... reported in 2013 within its online contractor management platform, ... key performance indicator (KPI) statistics. The ... publication is available in two industry specific ...
Breaking Biology Technology:LayerBio Awarded NIH Grant to Develop a Drug Delivery Device for Cataract Surgery 2iLab Solutions Announces Two New Leadership Positions to Meet the Needs of Its Growing Customer Base 2Major Pipette Distributor Pipette.com Announces Sartorius Year End Specials 2ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 2ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 3
... 16 Scientists at Biomodels have successfully ... treatment-relat e d fatigue (CTRF). The ... independent of anemia or weight loss and persists long after cancer ... will be presented today at the American Association for Cancer Research-NCI-EORTC ...
... Nov. 16 Neogen Corporation (Nasdaq: NEOG ) today announced ... With the split, shareholders of record on Nov. 30, 2009, will ... , The stock split will be effected in the form ... common stock on Dec. 15, 2009. As of today, Neogen has ...
... 16 Cornerstone Therapeutics Inc. (Nasdaq CM: CRTX), a ... significant products primarily for the respiratory and related markets, ... Chief Financial Officer, will be presenting a corporate overview ... at 9:00AM EST on Wednesday, November 18, 2009 ...
Cached Biology Technology:Biomodels Scientists Report Development of a Novel Model for Cancer Treatment-Related Fatigue 2Neogen Announces 3 for-2 Stock Split 2Cornerstone Therapeutics to Present at the 6th Annual Lazard Capital Markets Healthcare Conference 2
(Date:12/11/2014)... Dec. 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced the ... 2015-2019" report to their offering. ... is the adoption of multimodal biometric systems. Multimodal ... an individual for verification and identification purposes. This ...
(Date:12/10/2014)... , Dec. 9, 2014  Wake Forest Baptist Medical ... building for its School of Medicine. Funding for this ... capital campaign that will be publicly launched next summer. ... located in the former 60 series R.J. Reynolds Tobacco ... Quarter. Construction will begin immediately with plans to be ...
(Date:12/5/2014)... Utah , Dec. 4, 2014  Tute Genomics, ... raised $2.3 million in Series A1 funding led by ... investors also participated in the investment round. ... the healthcare community adopts next-generation sequencing and seeks new ... said Reid Robison , MD MBA, and CEO ...
Breaking Biology News(10 mins):Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 3
... Mere months after porcine epidemic diarrhea virus (PEDV) ... University of Minnesota researchers have developed a PEDV rapid ... available now, provides a way to quickly and cost-effectively ... Characterized by acute diarrhea and vomiting, a PEDV outbreak ...
... (NASDAQ: AWRE ), a leading supplier of biometrics ... reported financial results for its second quarter ended June 30, ... 2013 was $4.9 million, an increase of 19% compared to ... for the second quarter of 2013 was $307,000, or $0.01 ...
... weight should eat high fiber, low-fat food balanced with ... still burning fat, according to a report by an ... has a record number of overweight athletes, a population ... Nationally, more than 45 percent of high school linebackers ...
Cached Biology News:U of M researchers unveil nation's first porcine virus rapid detection test 2Aware, Inc. Reports Second Quarter 2013 Financial Results 2Aware, Inc. Reports Second Quarter 2013 Financial Results 3Aware, Inc. Reports Second Quarter 2013 Financial Results 4Aware, Inc. Reports Second Quarter 2013 Financial Results 5Athletes need to be careful to monitor diet, weight to maintain muscle mass 2Athletes need to be careful to monitor diet, weight to maintain muscle mass 3
... unit with motorized heated lid and skirted inner ... for microarrays and chips. The four screw-down points ... force of the motorized lid is set with ... results. This interchangeable Moto Alpha unit functions on ...
... These skirted micro test tubes are ... of polypropylene, these tubes have uniform walls ... nonsterile, with separate O-ring screw caps. The ... and have an operating range from -55 ...
... carriers to suit the widest possible range ... science laboratory. Labware carriers can be placed ... is simple for the user, thanks to ... are correctly guided into position. This allows ...
... For affinity chromatography, Affi-Prep protein ... (IgG), selectively remove IgG prior to ... adsorb immune complexes for antigen purification. ... region of immunoglobulins, especially IgG from ...
Biology Products: