Navigation Links
Research Published in Nature Medicine Shows Disruption of Chemokine Interactions Inhibits Atherosclerosis in Mice
Date:1/5/2009

San Diego-Based Carolus Therapeutics Focuses on Discovery and Development of Anti-Inflammatory Drugs Based on Collaborators' Findings at RWTH Aachen University in Germany

SAN DIEGO, Jan. 5 /PRNewswire/ -- Research published in Nature Medicine shows that the disruption of the interactions between two small signaling proteins called chemokines by a highly potent drug-like peptide inhibits the development of atherosclerosis in mice. San Diego-based Carolus Therapeutics Inc., which has in-licensed technology based on these and other findings of collaborators at RWTH Aachen University in Aachen, Germany, is focused on the discovery and development of drugs for the treatment of atherosclerosis and other disorders triggered by acute and chronic inflammation.

In their report, which was published online yesterday, RWTH Aachen University researchers demonstrated in a mouse model that the formation of heteromers of the chemokines platelet factor-4 (PF4, also known as CXCL4) and RANTES (CCL5) plays a regulatory role in the development of atherosclerosis. The scientists also showed that peptides designed to disrupt the formation of PF4-RANTES heteromers inhibited the development of atherosclerosis in mice that had a genetic propensity to develop the disease. (Koenen et al., Nature Med, 2009)

"Disrupting interactions between PF4 and RANTES is a novel approach to targeting inflammation that may lead to a new class of medications for the treatment of a variety of chronic and acute inflammatory diseases," said Jay Lichter, Ph.D., CEO of Carolus Therapeutics. "This approach could help to meet the unmet need for anti-inflammatory therapeutics for chronic diseases such as atherosclerosis, autoimmune diseases, rheumatoid arthritis, sepsis, asthma and multiple sclerosis."

PF4 and RANTES are chemokines that are secreted by platelets. Heteromerization of PF4 and RANTES results in recruitment of monoc
'/>"/>

SOURCE Carolus Therapeutics Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. Research Triangle Area Health Care Collaborative Launches Bridges to Excellence(R) Initiative to Improve Quality and Lower Costs
2. The Multiple Myeloma Research Consortium (MMRC) and Proteolix Initiate Phase 2 Clinical Trial Investigating Carfilzomib for the Treatment of Multiple Myeloma
3. BioMarin Licenses Technology From Leading Cystic Fibrosis Research Laboratory at the University of California, San Francisco
4. IDM Pharma Names Dr. Jeffrey W. Sherman Chief Medical Officer and Senior Vice President of Research and Development
5. Dawson James Securities Initiates Research Coverage on CryoCor, Inc. (Nasdaq: CRYO) with a Strong Buy Rating and $6.00 Target Price
6. eResearchTechnology to Present at the Thomas Weisel Healthcare Conference 2007 on September 5th
7. The Debiopharm Life Sciences Award Goes to Dr Nusser for his Outstanding Research in Neuroscience
8. Study Published in Clinical Cancer Research Confirms Potential Of Peregrines Bavituximab Combined With Radiation In Lung Cancer
9. Dow AgroSciences and Exelixis Plant Sciences Announce Major Research Collaboration, Asset Purchase to Advance Gene Discovery and Validation
10. Revolutionary Genomics Research Group Opens Boston Office; Provides DNA Evidence in Workers Comp Cases
11. Richard Schulz Receives the Coveted GCPj Award for Best Clinical Researcher of the Year
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/1/2015)...  Berg, a biopharmaceutical company committed to uncovering health ... from its trials using its cancer drug BPM 31510 ... triple negative breast cancer, at the 51 st ... (ASCO), May 29 – June 2 in ... one of the first cancer drugs guided in development ...
(Date:6/1/2015)... 1, 2015  Albany Molecular Research Inc. ... it has signed a collaborative agreement with ... structure-based drug discovery services to global pharmaceutical ... three-year agreement, AMRI gains access to HarkerBIO,s ... HarkerBIO,s customers will be able to access ...
(Date:6/1/2015)... , May 29, 2015 Research ... addition of the "2015 Strategies in ... report to their offering. This ... provides a comprehensive analysis of the POC ... growth, regulatory requirements, technological trends, competitive landscape, ...
(Date:6/1/2015)... 29, 2015 Research and Markets ( ... "2015 Strategies in the UK Flow Cytometry ... This report presents a comprehensive analysis of the ... issues pertaining to the French flow cytometry practice, ... and technological trends with significant market impact during ...
Breaking Biology Technology:Berg Presents Data On BPM 31510 Solid Tumor Trial At ASCO Annual Meeting That Reveals The Promise Of Metabolically Driven Therapy 2Berg Presents Data On BPM 31510 Solid Tumor Trial At ASCO Annual Meeting That Reveals The Promise Of Metabolically Driven Therapy 3AMRI and HarkerBIO Ink Collaborative Agreement in Buffalo, N.Y. 2AMRI and HarkerBIO Ink Collaborative Agreement in Buffalo, N.Y. 3Strategies in the UK Flow Cytometry Market 2015 2
... In their latest book, You: Being,Beautiful - The Owner,s ... Mehmet Oz, MD and Michael Roizen, MD refer to ... can "turbo-charge" those who need an,energy boost. Ribose ... to,stimulate the production of adenosine triphosphate (ATP) -- an ...
... Inc. (Nasdaq: IDIX ) announced today that ... upcoming JP Morgan 27th Annual Healthcare Conference on Wednesday, ... Westin St. Francis Hotel in San Francisco.The live and ... under "Calendar of Events" in the Idenix Investor Center ...
... 5 /PRNewswire-Asia-FirstCall/ -- BMP Sunstone,Corporation (Nasdaq: ... announced,that Sunstone (Tangshan) Pharmaceutical Co., Ltd., has been ... High tech status is awarded by the PRC ... development and,have substantial revenues generated by their own ...
Cached Biology Technology:You: Being Beautiful Authors Mehmet Oz, MD, & Michael Roizen, MD, Call Ribose One of the Decade's 'Real Nutritional Heroes' 2You: Being Beautiful Authors Mehmet Oz, MD, & Michael Roizen, MD, Call Ribose One of the Decade's 'Real Nutritional Heroes' 3BMP Sunstone Receives High Tech Status 2BMP Sunstone Receives High Tech Status 3
(Date:5/10/2015)... GOTHENBURG, Sweden , May 11, 2015 ... touch fingerprint sensors FPC1025 and FPC1155 from the distributor World ... one of FPC,s distributors in Asia . ... the sensors will be used by smartphone manufacturers in ... is included in the communicated revenue guidance of + 1 000 ...
(Date:5/7/2015)... 2015 Fingerprint Cards (FPC) ... FPC1035, FPC,s smallest touch fingerprint sensors to date.  ... for integration on the backside of the phone, ... possibilities to integrate touch fingerprint sensors in the ... possibilities for module manufacturers to customize the look ...
(Date:5/5/2015)... 5, 2015, NXT-ID, Inc. (NASDAQ: NXTD ) ... the growing mobile commerce market, reminds investors and media that ... is presenting  at CARTES SECURE CONNEXIONS AMERICA 2015, held in ... The three-day conference is organized into a series ... is themed Global Fraud: Where is the Trust in ...
Breaking Biology News(10 mins):Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 235 Million 2FPC Introduces its Smallest Touch Fingerprint Sensors to Date 2NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 2NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 3
... This week the scientific journal Ecology Letters ... plants worldwide. This global analysis has been based on more ... of 135 invasive plant species. The lead author, Dr. Montserrat ... adds: "This assessment would have been impossible to achieve ten ...
... Cowman from the Walter and Eliza Hall Institute in ... Royal Society, the UK,s peak academy promoting excellence in ... fellows inducted to the Royal Society in 2011, including ... peer review process on the basis of excellence in ...
... (Santa Barbara, Calif.) To David Cleveland, a professor of ... Santa Barbara County would be a great example of what ... a conventional agrifood network a local food system. ... counties in the United States in value of agricultural products, ...
Cached Biology News:Top Australian malaria researcher elected Fellow of the Royal Society 2Top Australian malaria researcher elected Fellow of the Royal Society 3UCSB localizing fruit, vegetable consumption doesn't solve environmental, health issues 2UCSB localizing fruit, vegetable consumption doesn't solve environmental, health issues 3
... is based on quantification of the green ... free orthophosphate. The rapid color formation from ... a spectrophotometer (600-660 nm) or on a ... have been optimized to offer superior sensitivity ...
The Odyssey Infrared Imaging System is a complete family of products that includes the Odyssey Imager, IRDye labeling reagents and Odyssey software for scan control and data analysis....
Compound(s) tested through a broad panel of 38 ligand binding and enzyme assays targeting the Central Nervous System. Used to determine selecitivty and potential CNS-Side Effect liabilities of compo...
...
Biology Products: