Navigation Links
Research Published in Nature Medicine Shows Disruption of Chemokine Interactions Inhibits Atherosclerosis in Mice
Date:1/5/2009

San Diego-Based Carolus Therapeutics Focuses on Discovery and Development of Anti-Inflammatory Drugs Based on Collaborators' Findings at RWTH Aachen University in Germany

SAN DIEGO, Jan. 5 /PRNewswire/ -- Research published in Nature Medicine shows that the disruption of the interactions between two small signaling proteins called chemokines by a highly potent drug-like peptide inhibits the development of atherosclerosis in mice. San Diego-based Carolus Therapeutics Inc., which has in-licensed technology based on these and other findings of collaborators at RWTH Aachen University in Aachen, Germany, is focused on the discovery and development of drugs for the treatment of atherosclerosis and other disorders triggered by acute and chronic inflammation.

In their report, which was published online yesterday, RWTH Aachen University researchers demonstrated in a mouse model that the formation of heteromers of the chemokines platelet factor-4 (PF4, also known as CXCL4) and RANTES (CCL5) plays a regulatory role in the development of atherosclerosis. The scientists also showed that peptides designed to disrupt the formation of PF4-RANTES heteromers inhibited the development of atherosclerosis in mice that had a genetic propensity to develop the disease. (Koenen et al., Nature Med, 2009)

"Disrupting interactions between PF4 and RANTES is a novel approach to targeting inflammation that may lead to a new class of medications for the treatment of a variety of chronic and acute inflammatory diseases," said Jay Lichter, Ph.D., CEO of Carolus Therapeutics. "This approach could help to meet the unmet need for anti-inflammatory therapeutics for chronic diseases such as atherosclerosis, autoimmune diseases, rheumatoid arthritis, sepsis, asthma and multiple sclerosis."

PF4 and RANTES are chemokines that are secreted by platelets. Heteromerization of PF4 and RANTES results in recruitment of monoc
'/>"/>

SOURCE Carolus Therapeutics Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. Research Triangle Area Health Care Collaborative Launches Bridges to Excellence(R) Initiative to Improve Quality and Lower Costs
2. The Multiple Myeloma Research Consortium (MMRC) and Proteolix Initiate Phase 2 Clinical Trial Investigating Carfilzomib for the Treatment of Multiple Myeloma
3. BioMarin Licenses Technology From Leading Cystic Fibrosis Research Laboratory at the University of California, San Francisco
4. IDM Pharma Names Dr. Jeffrey W. Sherman Chief Medical Officer and Senior Vice President of Research and Development
5. Dawson James Securities Initiates Research Coverage on CryoCor, Inc. (Nasdaq: CRYO) with a Strong Buy Rating and $6.00 Target Price
6. eResearchTechnology to Present at the Thomas Weisel Healthcare Conference 2007 on September 5th
7. The Debiopharm Life Sciences Award Goes to Dr Nusser for his Outstanding Research in Neuroscience
8. Study Published in Clinical Cancer Research Confirms Potential Of Peregrines Bavituximab Combined With Radiation In Lung Cancer
9. Dow AgroSciences and Exelixis Plant Sciences Announce Major Research Collaboration, Asset Purchase to Advance Gene Discovery and Validation
10. Revolutionary Genomics Research Group Opens Boston Office; Provides DNA Evidence in Workers Comp Cases
11. Richard Schulz Receives the Coveted GCPj Award for Best Clinical Researcher of the Year
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... It’s a hard truth: Nearly half of recent veterans who ... are failing to obtain a diploma or certificate within a ... an analysis by The Resume Place , a major ... college majors, which leads to underemployment, unemployment or just plain ... of post-9/11 veterans using GI Bill education benefits ...
(Date:7/28/2014)... DUBLIN , July 28, 2014 Research ... "Global Particle Size Analysis Market 2014-2018" report to their ... Particle size analysis is a technique used to determine ... powder or liquid. It is crucial to analyze the size ... material. Therefore, particle size analysis is performed to determine the ...
(Date:7/25/2014)... , July 25, 2014 Amgen (NASDAQ: ... Directors today declared a $0.61 per share dividend for ... paid on Sept. 5, 2014, to all stockholders of ... 14, 2014.  About Amgen Amgen is ... suffering from serious illnesses by discovering, developing, manufacturing and ...
(Date:7/25/2014)... July 25, 2014 According to a ... Drugs Market - Global Industry Analysis, Size, Share, Growth, ... drugs market is estimated at USD 161,056.5 million in ... of 10.1% from 2014 to 2020, to reach an ... The biological drugs market is witnessing a significant growth ...
Breaking Biology Technology:Resume Place: To Choose the Best College Majors, Veterans Need Early Career Counseling, Data Shows 2Resume Place: To Choose the Best College Majors, Veterans Need Early Career Counseling, Data Shows 3Resume Place: To Choose the Best College Majors, Veterans Need Early Career Counseling, Data Shows 4Global Particle Size Analysis Market 2014-2018 2Amgen Announces 2014 Third Quarter Dividend 2Amgen Announces 2014 Third Quarter Dividend 3Biological Drugs Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 2Biological Drugs Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 3
... Registry reveals that 70% of deaths in the stable stroke ... other than stroke, NICE, France, May 15 New ... Congress, highlight that among,those who die after a stroke the ... overall death rate is 4.45%, with,3.23% of these CV deaths ...
... , Chinese researchers have recently made a golden ... is a large ring-shaped molecule containing 36 gold atoms. The ... Universities of Beijing, Hong Kong, and Nanjing report their unusual ... is held together exclusively by goldgold bonds and is thus ...
... opportunities for micro and nano technologies. These challenges are ... the control and understanding of their behaviour. , This ... fibre analysis at the micro and nano-scale using state-of-the ... techniques. , Topics include fundamental effects of topography in ...
Cached Biology Technology:Stable Stroke Patients More Likely to Die From a Nonstroke Cardiovascular Event Than a Further Stroke 2Stable Stroke Patients More Likely to Die From a Nonstroke Cardiovascular Event Than a Further Stroke 3Stable Stroke Patients More Likely to Die From a Nonstroke Cardiovascular Event Than a Further Stroke 4Stable Stroke Patients More Likely to Die From a Nonstroke Cardiovascular Event Than a Further Stroke 5Golden nanocrown 2Micro and Nano Scale Characterization of Fibers 2
(Date:7/28/2014)... Food and Drug Administration (FDA) for other purposes can ... human cells, including those that cause Legionnaires, disease, brucellosis, ... mBio , the online open-access journal of the American ... non-antibiotic drugs that could one day help curb bacterial ... list inhibit the growth of at least three of ...
(Date:7/28/2014)... coral communities showing signs of damage from the Deepwater Horizon ... in the Gulf of Mexico. The discovery was made by ... Penn State University. A paper describing this work and additional ... Mexico will be published during the last week of July ... Proceedings of the National Academy of Sciences . , "The ...
(Date:7/28/2014)... the South Pole in 1911, but new research shows ... , Using data from 16 ice cores collected from ... South Pole, a group led by Joe McConnell of ... the most accurate and precise reconstruction to date of ... described in an article published today in the online ...
Breaking Biology News(10 mins):New route to identify drugs that can fight bacterial infections 2Impact of Deepwater Horizon oil spill on coral is deeper and broader than predicted 2Lead pollution beat explorers to South Pole, persists today 2Lead pollution beat explorers to South Pole, persists today 3
... aspires to a lifetime of addiction. But their brains ... journal Neuropsychopharmacology this week, Rockefeller University researchers ... can sustain lifelong and permanent changes in their reward ... and make such adolescents more vulnerable to the drug,s ...
... of Palm Vein Authentication Technology with, Single-Sign On Solutions ... ... Passwords, SUNNYVALE, Calif., Sept. 9 Fujitsu Computer ... products including,hard disk drives, peripherals and biometric security solutions, ...
... novel way to improve survival and recovery rate after ... Stem Cell Research by scientists at Singapore,s Institute ... and The Netherlands, University Medical Center Utrecht. ... the first non-cell based therapeutic application of human embryonic ...
Cached Biology News:Abuse of painkillers can predispose adolescents to lifelong addiction 2Fujitsu Announces PalmSecure(TM) LOGONDIRECTOR 2Fujitsu Announces PalmSecure(TM) LOGONDIRECTOR 3Fujitsu Announces PalmSecure(TM) LOGONDIRECTOR 4Human embryonic stem cell secretions minimized tissue injury after heart attack 2Human embryonic stem cell secretions minimized tissue injury after heart attack 3
EML1 (K-16)...
Bovine Renal Artery Endothelial Cells (BRAEC) (>500,000 cells)...
Bovine Brain Microvascular Endothelial Cells (BBMVEC) (>500,000 cells)...
... ,• Eliminates nonspecific products due to ... specificity allows extension through DNA regions which ... Leaves an 'A' overhang ,TEMPase II ... DNA Polymerase that remains inactive at ...
Biology Products: