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Research Foundations Collaborate To Fund Phase 1 Study Of Cancer Drug In Alzheimer's Disease Patients
Date:4/24/2013

mory and cognition. To further advance bexarotene and related compounds through drug development, Dr. Landreth co-founded the biotechnology company ReXceptor in 2011.

"Funding for pilot clinical trials is in short supply," said Stacy Pagos Haller , the president and chief executive officer of BrightFocus Foundation. "Partnering with another foundation in the community that shares a common goal makes research like this possible. In this time of shrinking corporate and pharmaceutical budgets, this project -- from animal model to clinical trial -- would not happen without the catalytic support of our organizations. The effort to cure Alzheimer's disease needs many voices. This project demonstrates what can be achieved when a mission of one organization becomes a movement of many."

Partial funding for ReXceptor Inc.'s trial includes The Charles Evans Foundation/Alzheimer's Drug Discovery Award to ReXceptor Therapeutics of $500,000 and a $250,000 contribution from BrightFocus to the collaboration with ADDF. Additional funds are originating from other sources of translational support, including a $200,000 investment from CWRU, to enable conduct of the full Phase I study.

The Phase I trial, set to commence later this year, will evaluate at least 12 healthy human subjects. This study will be conducted by C2N Diagnostics and Compass Research, Inc. and will employ proprietary technology allowing the measurement of apoE and amyloid beta related biomarkers in the spinal fluid of individuals following treatment with bexarotene.

About the Alzheimer's Drug Discovery Foundation (ADDF)
The mission of the Alzheimer's Drug Discovery Foundation (ADDF) is to accelerate the discovery of drugs to prevent, treat and cure Alzheimer's disease, related dementias and cognitive aging. The ADDF has invested nearly $60 million to fund 400 Alzheimer's drug discovery programs and
clinical trials in academic centers and biotechnol
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SOURCE Alzheimer's Drug Discovery Foundation
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