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Research Demonstrates Safety of 3-Fucosyllactose (3-FL) as a Nutritional Ingredient in Food and Dietary Supplements
Date:2/26/2020

Continuing its leading research on human milk oligosaccharides (HMOs), DuPont Nutrition & Biosciences (DuPont) recently published the results of its safety assessment on the biotechnologically produced 3-Fucolsyllactose (3-FL) HMO.

3-FL is one of over 130 HMOs currently identified in human milk. These complex carbohydrates are indigestible and therefore function as a prebiotic by promoting early microbial colonization of the gut. This, in turn, provides benefits related to immunity, digestion and potentially cognitive health – benefits that begin in infancy but have a lifelong impact on human health.

This new safety study supports past research which indicated that commercially produced HMOs can mimic some of the health-promoting effects of the HMOs present in human milk. DuPont has been a pioneer in the field of HMOs and launched 2’-fucosyllactose (2’-FL) in 2018 under the name CARE4U™ for infant nutrition and dietary supplements. The important results of this current study help DuPont continue to build the framework for the upcoming launch of CARE4U™ 3-FL.

The Results

To investigate safety of this new ingredient for early life nutrition, 3-FL was produced by fermentation and then assessed for acute oral toxicity, in vitro and in vivo of genetic toxicity, and included a sub chronic rodent feeding study. These are standardized testing protocols for all new ingredients.

The results showed that subchronic dietary exposure of rats to 3-FL did not produce any statistical or biologically relevant differences in growth, food intake or efficiency, clinical observations, or clinical or anatomic pathology changes. The weight of evidence from these studies support the safe use of 3-FL produced using biotechnology as a nutritional ingredient in foods and dietary supplements.

“This is an important milestone for the launch of Care4U™ 3-FL, the next HMO from DuPont. A robust safety assessment has been completed for 3-FL demonstrating the safe use as a nutritional ingredient in foods,” stated Ratna Mukherjea, Ph.D., Technical Fellow and Global R&D Leader for Human Milk Oligosaccharides. “We continue to innovate in Early Life Nutrition by providing ingredients such as HMOs and probiotics to support good nutrition in the First 1000 Days.”

You can read more about this study at https://www.sciencedirect.com/science/article/pii/S0278691519306088?via%3Dihub.

About DuPont™ Danisco®

DuPont™ Danisco® is the brand for a range of products that help provide enhanced bioprotection, an improved nutritional profile, and better taste and texture with greater cost efficiency and lower environmental impact, meeting the needs of manufacturers of food and beverages and dietary supplements. Through the work of the global network of food scientists and technologists in DuPont, the Danisco® range is supported by a uniquely broad spectrum of know-how across applications and processing.

About DuPont Nutrition & Biosciences

DuPont Nutrition & Biosciences applies expert science to advance market-driven, healthy and sustainable solutions for the food, beverage, dietary supplement and pharmaceutical industries. We also use cutting-edge biotechnology across a range of markets to advance bio-based solutions to meet the needs of a growing population, while protecting our environment for future generations. We are innovative solvers who help our customers turn challenges into high-value business opportunities. For more information: http://www.dupontnutritionandbiosciences.com or http://www.biosciences.dupont.com

About DuPont

DuPont (NYSE: DD) is a global innovation leader with technology-based materials, ingredients and solutions that help transform industries and everyday life. Our employees apply diverse science and expertise to help customers advance their best ideas and deliver essential innovations in key markets including electronics, transportation, construction, water, health and wellness, food and worker safety. More information can be found at http://www.dupont.com.

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2/25/2020

DuPont™, the DuPont Oval Logo, and all trademarks and service marks denoted with ™, ?
or ® are owned by affiliates of DuPont de Nemours, Inc. unless otherwise noted.

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