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Reportlinker Adds Upstream Processing in Biopharmaceuticals - Increasing Use of Low-Cost Disposable Bioreactors to Drive the Upstream Bioprocessing Market

facturing Process Overview 14

3.2.1 Overview of Microbial Fermentation 15

3.2.2 Overview of Mammalian Cell Culture Systems 15

3.2.3 Cell Banking and Seed Culture 15

3.2.4 Overview of Upstream Process 16

3.2.5 Harvest 17

3.2.6 Downstream Process (DSP) 17

3.2.7 Formulation 19

3.2.8 Comparison of Upstream Processing and Downstream Processing 19

4 Upstream Processing in Biopharmaceuticals – Upstream Process In Detail 20

4.1 Introduction 20

4.2 Bioreactors and Cells 21

4.3 In Process Control 23

4.3.1 pH 23

4.3.2 Temperature 24

4.3.3 Holding and Storage Time 24

4.3.4 Shear Forces 24

4.3.5 Key Points to be remembered while starting Up Upstream Processes 24

4.3.6 Major Issues during Upstream Processing 25

4.4 Scale Up 25

4.4.1 The Upstream Output can be increased 26

4.4.2 Upstream Bioprocessing 28

4.4.3 Some Key Points While Starting Up Upstream Processes 28

4.4.4 Emerging Production Systems in Upstream Bioprocess 29

4.4.5 Conclusion 29

5 Upstream Processing in Biopharmaceuticals – Market Characterization 30

5.1 Culture Media Overview 30

5.1.1 Cell Culture 30

5.2 Key Biologic Reagents 31

5.2.1 Amino Acids 31

5.2.2 Growth Factors 31

5.2.3 Albumin 31

5.2.4 Transferrin 31

5.3 Culture Media/Reagent Suppliers 32

5.4 Culture Media/Reagent Market Size 33

5.4.1 Market Drivers 34

5.4.2 Market Restraints 35

5.5 Bioreactor 35

5.5.1 Selection of Bioreactors 35

5.5.2 Batch Bioreactor 36

5.5.3 Continuous Bioreactor 37

5.5.4 Submerged Bioreactors — Stirred Tank 38

5.5.5 Airlift Bioreactor 38

5.6 Upstream Process and CMO 39

5.6.1 Why CMO? 39

5.6.2 Build Vs. Buy Decision 39

5.6.3 Selection of CMOs 41

5.6.4 CMO- Upstream Market Size 43

5.6.5 Dr

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