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Reportlinker Adds Small Molecule Kinase Inhibitors Report
Date:9/8/2009

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3. KINASE INHIBITORS: A RUDIMENTARY OVERVIEW II-40

Kinase Inhibitors: A Definition II-40

Kinase Inhibitors Vs Monoclonal Antibodies (mAbs): A Comparison II-40

Comparison of Various Pharmacological and Pharmacokinetic

Parameters For Small Molecules and Monoclonal Antibodies II-41

Types of Protein Kinase Inhibitors: A Classification II-41

Receptor Tyrosine Kinase (RTK) Inhibitors II-42

EGFR (Epidermal Growth Factor Receptor) Inhibitors II-42

HER2 Inhibitors II-42

VEGF (Vascular Endothelial Growth Factor) Inhibitors II-42

FLT3 (Fms-like tyrosine kinase 3) Inhibitors II-43

Non- Receptor Tyrosine Kinase Inhibitors II-43

BCR-Abl Kinase Inhibitors II-43

Src Kinase Inhibitors II-43

Janus (JAK) Kinase Inhibitors II-44

Serine-Threonine Kinase Inhibitors II-44

mTOR (Mammalian Target of Rapamycin) Inhibitors II-44

Rho Kinase Inhibitors II-44

CDK (Cyclin Dependent Kinase) Inhibitors II-45

Protein Kinase C (PKC) InhibitorsII-45

PI3K (Phosphatidylinositol-3-Kinase) Inhibitors II-45

Aurora Kinase Inhibitors II-45

MAP (Mitogen activated protein) / MEK Inhibitors II-46

JNK (C-JUN N-TERMINAL KINASE) INHIBITORS II-46

Others II-46

4. PRODUCT LAUNCHES II-47

KAI Initiates Third Phase Iia Trial for KAI-1678 II-47

SuperGen Discovers a New Class of Kinase Inhibitors II-47

AVEO Joins Hands with Biogen to Develop and Market ErbB3-

Targeted AntibodiesII-47

AVEO Identifies New Indication for AV-951 Triple VEGF

Receptor Inhibitor II-48

GPC Biotech Demonstrates Role of Kinase Inhibitor in Multiple Myeloma Treatment II-48

MD Biosciences and PharmaGap Join Hands II-48

New JAK Inhibitor Drug from Pfizer Enters Phase III Trial II-48

Millennium Commences Phase II Trials for MLN8237 II-49


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5. BioSpecifics Technologies Corp. to Present at CapStone Investments Third Annual Small-Cap Investor Conference
6. Global Small Molecule Kinase Inhibitors Market to Reach $16.2 Billion by 2015, According to a New Report by Global Industry Analysts, Inc.
7. Debiopharm Group and Moffitt Cancer Center Sign Development and Commercialisation Agreement for Small Molecule Debio 0928 in Early Preclinical Development for Treatment of Solid Tumours
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