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Case Studies
Case Study #1 - SNPs in Gene for P-glycoprotein Affect Antidepressant Response
Case Study #2 - Celera Studying SNPs Associated With Heart Disease
Case Study #3 - Synonymous SNPs Alter mRNA Splicing with Obesity
Case Study #4 - University of Ottawa Heart Institute (UOHI) Coronary Artery Disease Research
Case Study #5 - Development of Miniaturized Integrated SNP Genotyping Microsystems
CHAPTER THREE: INDUSTRY, TECHNOLOGY, REGULATORY TRENDS
Industry Trends
Period of Limbo While Funding and Content Materialize
Consolidation Occurring in Array and Life Science Markets
Drug and Diagnostics Industries More Comfortable
Broad Acceptance of SNP Analysis' Value
Core Labs Becoming Established Paradigm
Technology Trends
Rapid Rate of Product Introductions
Increased Multiplexing Creates Improved Products
End-Users Attracted to Larger-Scale SNP Platforms
Complexity of Biological Systems Requires Multiple Techniques
Miniaturization of Equipment and Instruments
Regulatory Trends
Introduction
March 2004 - Critical Path Initiative
March 2005 - "Guidance for Industry - Pharmacogenomic Data Submissions"
March 2006 - Critical Path Opportunities
November 2006 - "Recommendations for the Generation and Submission of Genomic Data"
August 2007 - Pharmacogenomic Data Submissions — Companion Guidance
December 2007 - EGAPP Reviews Use of
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