Navigation Links
Reportlinker Adds R&D Trends: Osteoporosis - Strong pipeline bodes well for future treatment

NEW YORK, April 26, 2011 /PRNewswire/ -- announces that a new market research report is available in its catalogue:

R&D Trends: Osteoporosis - Strong pipeline bodes well for future treatment

Over the last 12 months, there have been encouraging developments in the osteoporosis pipeline, with new therapies either receiving regulatory approval or launching. Moreover, both in the clinical and preclinical pipeline, companies continue their quest to bring to market a new, safe, effective, and affordable anabolic drug to address unmet need in the osteoporosis market. Understand key dynamics in the R&D pipeline for new osteoporosis therapies Benchmark novel and existing therapies using the target product profile identified by DatamonitorSupport R&D decision making by evaluating osteoporosis clinical trial designs that have set a precedent, as well as analysis of discontinued projectsAccess Datamonitor's prediction of how the treatment landscape may change in the next 20 years The osteoporosis pipeline remains well stocked, with several products continuing their clinical trials and no significant discontinuations. There most exciting novel candidates with new mechanisms of action continue to be the new antiresorptives cathepsin K inhibitors and the anti-sclerostin monoclonal antibodies anabolics. The osteoporosis treatment paradigm has been largely static for the past 20 years, but this trend is likely to change as new drugs reach the market. It is probable that the fracture prevention strategy will evolve from just focusing on increasing bone mineral density to improving the bone quality and strength. The major change in the treatment of osteoporosis will be the launch of new efficacious and safe anabolic treatments, allowing physicians to use these treatments earlier in the algorithm and in a wider category of patients. In particular companies are targeting the Wnt pathway, bone morphogenetic proteins, and insulin-like growth factor. What are the key trends in the osteoporosis pipeline? What is the clinical gold standard and how do new candidates have to compare to this to successfully penetrate the market? How will new osteoporosis treatments evolve in the next 20 years? What are the requirements of European and US regulatory bodies to ensure approval of a novel candidate?

Executive Summary

Strategic scoping and focus

Datamonitor key findings

Related reports





Osteoporosis pipeline

The osteoporosis pipeline remains robust

Companies are focusing on developing anabolics as competition in the antiresorptive market increases

Mechanism of action

Late-stage development compounds recently discontinued


Comparator therapies

Fosamax (alendronate; Merck & Co)

Target product profile versus current level of attainment


Preclinical trials

Two different animal species tests are required by both the FDA and EMA

Preclinical trial design should reflect the clinical indication

Clinical trials

The FDA and EMA have different patient inclusion requirements for osteoporosis trials

Clinical endpoints

Future developments in clinical trial design

Trial endpoints unlikely to change


New targets for osteoporosis treatments

Targets for antiresorptive treatment

Targets for anabolic treatment


Screening and osteoporosis diagnosis

Increased use of FRAX will lead to more osteoporosis prevention

Change in treatment outcomes

Focusing on bone quality

New treatment strategies

Anabolic treatments are likely to be used earlier in the treatment algorithm

Combination therapies

Personalized medicine


Journal papers



Contributing experts

Conferences attended

Report methodology

To order this report:

: R&D Trends: Osteoporosis - Strong pipeline bodes well for future treatment

More  Market Research Report

Check our  Company Profile, SWOT and Revenue Analysis!

Nicolas Bombourg
US: (805)652-2626
Intl: +1 805-652-2626

SOURCE Reportlinker
Copyright©2010 PR Newswire.
All rights reserved

Related biology technology :

1. Reportlinker Adds Infectious Disease Molecular Diagnostic Testing
2. Reportlinker Adds Smart Glass: Technologies and Global Markets Report
3. Reportlinker Adds Synthetic Biology: Emerging Global Markets Report
4. Reportlinker Adds Proteomics: Technologies and Global Markets Report
5. Reportlinker Adds Nanomedicine Report
6. Reportlinker Adds Small Molecule Kinase Inhibitors Report
7. Reportlinker Adds Nanoporous Materials Report
8. Reportlinker Adds Membrane Bioreactors Report
9. Reportlinker Adds The Future of Orphan Diseases Therapeutics - Market Forecasts to 2015, Pipeline Analysis and Reimbursement
10. Reportlinker Adds High-Tech Patient Monitoring Systems Markets (Remote and Wireless Systems, Data Processing, EMR Data Transfer) Report
11. Reportlinker Adds In Vitro Diagnostics in a Recession: IVD Market Forecasts, Analysis and Success Strategies Report
Post Your Comments:
(Date:11/24/2015)... 24, 2015 Capricor Therapeutics, Inc. ... the discovery, development and commercialization of first-in-class therapeutics, today ... Officer, is scheduled to present at the 2015 Piper ... a.m. EST, at The Lotte New York Palace Hotel ... . --> . ...
(Date:11/24/2015)... INCLINE VILLAGE, Nev. , Nov. 24, 2015  PDL ... John P. McLaughlin , the company,s president and chief ... Piper Jaffray Healthcare Conference next week in New ... and will occur on Tuesday, December 1, 2015 at 9:30 ... and Presentations." Please connect to the website at least 15 ...
(Date:11/24/2015)... ... , ... Whitehouse Laboratories is pleased to announce that it has completed construction ... dedicated to basic USP 61, USP 62 and USP 51 testing specific to raw ... and micro testing performed by one supplier. Management has formally announced that ...
(Date:11/23/2015)... , Nov. 24, 2015 Women with a certain ... exams face a higher risk of lung cancer than men ... next week at the annual meeting of the Radiological Society ... --> --> Lung nodules are ... as solid or subsolid based on their appearance on CT. ...
Breaking Biology Technology:
(Date:11/2/2015)...  SRI International has been awarded a contract of ... to the National Cancer Institute (NCI) PREVENT Cancer Program ... modern testing and support facilities, and analytical instrumentation to ... studies to evaluate potential cancer prevention drugs. ... Drug Development Program is an NCI-supported pipeline to bring ...
(Date:10/29/2015)... Va. , Oct. 29, 2015 Daon, ... today that it has released a new version of ... customers in North America have ... IdentityX v4.0 also includes a FIDO UAF certified ... are already preparing to activate FIDO features. These customers ...
(Date:10/29/2015)... , October 29, 2015 ... biometric authentication company focused on the growing mobile ... wallet announces that StackCommerce, a leading marketplace to ... featuring the Wocket® smart wallet on StackSocial for ... ) ("NXT-ID" or the "Company"), a biometric authentication ...
Breaking Biology News(10 mins):