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Reportlinker Adds Monoclonal Antibodies: Pipeline Analysis and Competitive Assessment

development, and those still at the preclinical stage that are likely to play an important role in the advancement of the field.

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Executive Summary

Chapter 1



1.1. What Is an Antibody?

1.2. What Is a Monoclonal Antibody?

Chapter 2




2.1. Key Breakthroughs in the First 35 Years of Monoclonal Antibody


Murine-Derived Monoclonal Antibodies

Chimeric Monoclonal Antibodies

Humanized Monoclonal Antibodies

Fully Human Monoclonal Antibodies

Antibody Fragments

Antibody Conjugates

2.2. Monoclonal Antibody Libraries and Display Technologies

Phage Display

MedImmune (AstraZeneca)



Biosite (Inverness Medical Innovations)

Affimed Therapeutics

Ribosome Display

MedImmune (AstraZeneca)


Other Library-Based Technologies

Alexion Pharmaceuticals

BioInvent International

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Table of Contents

MSM Protein Technologies


Morphotek (Eisai Corp. of North America)


Sorrento Therapeutics

2.3. Other Technologies for Designing Monoclonal Antibodies

Techniques for Improving Hybridoma Production

New Techniques for Generating Animal-Derived Monoclonal


GENOVAC (Aldevron)


North Coast Biologics

Chiome Bioscience

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