Navigation Links
Reportlinker Adds Immunogenicity to Biologics
Date:11/3/2010

ute of administration 1.6. The influence of dose 1.7. Influence of immune status of patient

2. Clinical Consequences of an Immune Response 2.1. Examples of severe clinical consequences 2.2. Therapeutic proteins with reduced immunogenicity or no clinical consequences 2.3. Risk factors and the monitoring of potential immunogenicity

3. References

Chapter 3 Practical Approach to Assay Development and Validation

Meenu Wadhwa* and Robin Thorpe** * Section Leader, Cytokines and Growth Factor Section, Biotherapeutics Group ** Head, Biotherapeutics Group, National Institute for Biological Standards and Control, UK

1. Introduction

2. Strategy for immunogenicity assessment

3. Assays for detection of antibodies and their practical application 3.1. Screening assays 3.2. Technical challenges associated with screening assays 3.3. Antibody controls and reagents for antibody assays 3.4. Limits of detection, sensitivity, cut-points and other critical issues 3.5. Interpretation of results and data analysis 3.6. Guidance On Antibody Assays for Immununogenicity Assessment 3.7. Validation of assays 3.8. Impact of antibodies on clinical response

4. References

Chapter 4 Considerations for the Development and Validation of Assays for Neutralising Antibodies and Interpretation of Data

Dr Deborah Finco-Kent, Senior Scientist, Immunogenicity Assay Coordinator, Pfizer Inc., USA

1. Introduction 1.1. Impact of neutralising antibodies on clinical results: safety and efficacy 1.2. Significance of neutralising antibody assays for pre-clinical testing 1.3. When to determine neutralising activity

2. Design and development of neutralising assays 2.1. How to develop quickly and with minimum cost 2.2. Ligand-binding versus cell-based assays 2.3. Sensitivity required 2.4. Other assays 2.5. Factors affecting assay performance 2.6. How to deal with drug interference 2.7. Determination and detection of cut points
'/>"/>

SOURCE Reportlinker
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related biology technology :

1. Reportlinker Adds Infectious Disease Molecular Diagnostic Testing
2. Reportlinker Adds Smart Glass: Technologies and Global Markets Report
3. Reportlinker Adds Synthetic Biology: Emerging Global Markets Report
4. Reportlinker Adds Proteomics: Technologies and Global Markets Report
5. Reportlinker Adds Nanomedicine Report
6. Reportlinker Adds Small Molecule Kinase Inhibitors Report
7. Reportlinker Adds Nanoporous Materials Report
8. Reportlinker Adds Membrane Bioreactors Report
9. Reportlinker Adds The Future of Orphan Diseases Therapeutics - Market Forecasts to 2015, Pipeline Analysis and Reimbursement
10. Reportlinker Adds High-Tech Patient Monitoring Systems Markets (Remote and Wireless Systems, Data Processing, EMR Data Transfer) Report
11. Reportlinker Adds In Vitro Diagnostics in a Recession: IVD Market Forecasts, Analysis and Success Strategies Report
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2015)... September 1, 2015 Shire plc (LSE: ... Sara Mathew to its Board of Directors as a ... Audit, Compliance & Risk Committee of the Shire Board. Both ... Sara previously served as Chairman, President and Chief Executive ... 2013. During her 12-year tenure at D&B, she helped drive ...
(Date:8/31/2015)... , Aug. 31, 2015 /PRNewswire/ - BIOREM Inc. (TSXV: ... totalling $5.7 million. The orders are for air emission abatement projects ... particular note is a large order for a municipality in ... will be replacing a competitor,s system that failed to meet ... our engineered solutions," said Derek S. Webb , President ...
(Date:8/31/2015)... -- MabVax Therapeutics Holdings, Inc. (OTCQB: MBVX) aclinical stage ... antibody, HuMab 5B1, will be garnering major attention as ... World Molecular Imaging Congress (WMIC) being held in ... the Department of Radiology at Memorial Sloan Kettering Cancer ... MabVax,s lead antibody as a PET imaging agent and ...
(Date:8/31/2015)... 31, 2015 Research and Markets ( http://www.researchandmarkets.com/research/k6lcp2/mexico_biomedical ... Biomedical Sensors Market - Growth, Trends & Forecasts (2014-2020)" ... The Mexico Biomedical Sensors market is estimated at $0.20 ... the period 2014-2020 The near future will ... formulation of each individual. These sensors can be set ...
Breaking Biology Technology:Shire Appoints Sara Mathew to Board of Directors 2MabVax Therapeutics HuMab 5B1 Antibody Is Highlighted at Upcoming World Molecular Imaging Congress in Five Separate Presentations 2MabVax Therapeutics HuMab 5B1 Antibody Is Highlighted at Upcoming World Molecular Imaging Congress in Five Separate Presentations 3MabVax Therapeutics HuMab 5B1 Antibody Is Highlighted at Upcoming World Molecular Imaging Congress in Five Separate Presentations 4Mexico Biomedical Sensors Market Report 2015-2020 2
... in German . , Amphiphilic molecules, ... (hydrophobic) end, spontaneously aggregate in aqueous solutions to make ... for the effects of detergents and soaps. Dirt is ... water-soluble. Cell membranes are also based on this principle: ...
... Inc. (NASDAQ: AEZS , TSX: AEZ), a ... will announce its fourth quarter and full-year 2008 financial ... 11, 2009. The Company will host a conference call ... day at 10:00 a.m., Eastern Time. , Participants may ...
... Medicsight PLC, a subsidiary of MGT Capital Investments, ... in the development of Computer-Aided Detection (CAD) and image ... diagnosis of disease, is pleased to announce it has ... computer-aided detection software, today at the European Congress of ...
Cached Biology Technology:Bristly spheres as capsules 2Medicsight Unveils New Version of ColonCAD(TM) at ECR 2009 2Medicsight Unveils New Version of ColonCAD(TM) at ECR 2009 3
(Date:8/3/2015)... SAN JOSE, Calif. , Aug. 3, 2015 /PRNewswire/ ... developer of human interface solutions, today announced that members ... investment community at the Pacific Crest Global Technology Leadership ... Mountain Time. The conference will be held at the ... The presentation may include forward-looking information. ...
(Date:7/31/2015)... SHENZHEN, China , 31 de julio de 2015 ... sobre Genómica (ICG-10,  www.icg-10.org ) del 22 al 25 ... . La conferencia celebra su décimo ... se ha convertido en una de las reuniones anuales ... ,ómicas, y es una de las conferencias científicas más ...
(Date:7/31/2015)... , Chine, 31 juillet 2015 La ... www.icg-10.org ) sera organisée par le BGI du ... Shenzhen en Chine. La ... son inauguration en 2006, l,ICG est devenue l,une ... le domaine des « omiques » et c,est aussi la ...
Breaking Biology News(10 mins):La 10ª Conferencia Internacional sobre Genómica (ICG-10) comienza en octubre 2La 10ª Conferencia Internacional sobre Genómica (ICG-10) comienza en octubre 3La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 2La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 3
... the United Kingdom are reporting an advance toward ... Getting molecules to move quickly in a desired ... has broad implications, the scientists say, raising the ... in specific directions to treat diseases. It also ...
... Europe,s largest scientific research organizations are teaming up to ... oil sands resources. The U of A and The ... five year agreement called the Helmholtz Alberta Initiative (HAI). ... production processes by developing technologies that address these sustainability ...
... the AZTI-Tecnalia researchers, the first estimations of the geographical location ... migrations between the Azores and Portugal during the winter, later ... also that it had dived, during the winter, to depths ... tagged 26 of August 2008 in the Gulf of Bizkaia ...
Cached Biology News:U of A and leading German researchers team up to build oil sands sustainability 2Juvenile bluefin tunas can dive to depths of more than 1000 meters 2
MOUSE ANTI HUMAN MOC31:AZIDE FREE...
Incomplete Adjuvant...
2,4-Dinitrophenyl hapten is conjugated to Human Serum Albumin (HSA) protein through lysine....
PGF1α-d4 contains 4 deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of PGF1α by GC- or LC-mass spectrometry....
Biology Products: