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Date:3/21/2011

FDA's Subpart H Approval for Revlimid in

Myelodysplastic Syndromes 72

US FDA Approves OSI's Tarceva® for Treating Pancreatic Carcinoma 72

OSI Obtains FDA Approval for Tarceva™ In the Treatment of NSCLC 73

FDA Grants Approval to Erbitux® in the Treatment of Metastatic

Colorectal Carcinoma 73

AstraZeneca Obtains FDA Approval for Iressa in NSCLC Treatment 74

9. RECENT INDUSTRY ACTIVITY 75

Genentech to Carry Out Additional Trial of Avastin in Her2-

negative mBC 75

Pfizer to Seek regulatory Clearance for Axitinib in Europe and US 75

FDA to Withdraw Avastin's Approval for Breast Cancer 75

Eyetech Receives QTDP Grant To Develop Extended- Release

Formulation of Macugen® 75

sanofi-aventis and Regeneron to Continue VELOUR Trial as Planned 76

EntreMed Enters into Financing Deal for ENMD-2076 Development 76

Chugai Pharmaceuticals Fulfills Condition for Avastin's Approval 76

Gilead Sciences to Take Over CGI Pharma 77

Mersana Commences XMT-1107 Phase I Clinical Trial 77

Astellas Pharma Acquires OSI Pharmaceuticals 77

Roche to Conduct a Trial on Anti-Cancer Antibody TB-403 77

Mersana Therapeutics Inks License Agreement With Teva 78

Acceleron Publishes Pre-clinical Data Study on ACE-041 78

Antisense Raises Capital to Continue Phase III Trabedersen Trial 78

GSK Receives Positive Opinions from EMEA for Two Cancer Medicines 79

EMEA Issues Positive Opinion on GSK's Votrient 79

EMEA Issues Positive Opinion on GSK's Anti Cancer Drug

Candidate, Tyverb 79

Abbott Enters into Licensing Agreement with Pierre Fabre 80

Arno Therapeutics Inks Global Licensing Agreement with OSU 80

BI Initiates Late Stage Clinical Trials for Two Oncology Drug

Candidates 80

AnGes Obtains US FDA Approval for Phase III Trial of Collategene™ 80

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