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Reportlinker Adds Global Angiongenesis Inhibitors and Stimulators Industry
Date:3/21/2011

17

Regulatory Approvals 18

Erbitux in Head and Neck Cancer 18

Glivec/Gleevec (imatinib mesylate) 19

Herceptin (Tractuzumab) 19

Iressa (gefitinib) 19

Sutent (Sunitinib) 20

Other Regulatory Approvals 20

Sunitinib in Various Indications 20

Sunitinib in Renal Cell Carcinoma (RCC) 20

Sutent in Gastrointestinal Stromal Tumors 21

Cost Related Issues 21

Tarceva (Erlotinib) 21

Other Regulatory Approvals 22

Thalomid® (thalidomide) 22

Table 3: Thalomid - Percentage Breakdown Based on Relative

Oncology Application (includes corresponding Graph/Chart) 22

Cilengitide 23

Imiquimod 23

Angiogenesis Inhibitors - Pipeline Status 24

Select Anti-Angiogenesis Drugs in Phase III Development 24

Select Anti-Angiogenesis Drugs in Phase II Development 25

Select Anti-Angiogenesis Drugs in Phase I Development 26

Approved and Pipeline Indications of Select Anti-VEGF/VEGFR

Drugs 26

Novel Targets for Anti-Angiogenic Activity 27

Approved and Pipeline HER Receptor-Targeting Drugs 28

Select Approved and Pipeline m-TOR Inhibitors 28

Integrins 28

Select Integrin Targeting Drugs Under Development 29

Angiogenic Inhibitors - By Disease Application 29

Cancer 29

Various Types of Cancers Targeted by Angiogenesis

Inhibitors in Phase III Clinical Development 29

Diabetic Retinopathy 30

Female Reproductive Cycle 30

Psoriasis 30

Inflammatory Diseases 30

Table 4: Classification of Anti-Angiogenic Compounds Based

on Most Commonly Targeted Indication (includes

corresponding Graph/Chart) 31

Angiogenesis Inhibitors in Eye Related Diseases 31

Age-Related Macular Degeneration 31

Wet AMD 32

Dry AMD 32

Select Anti-Angiogenic Drugs Approved by FDA for Treatment

of Eye Diseases 32

Angiogenesis In
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