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Reportlinker Adds Gene Therapy - technologies, markets and companies

em cells 82

Lentiviral vectors for gene transfer to marrow stem cells 82

Use of mesenchymal stem cells for gene therapy 83

Microporation for transfection of MSCs 83

In utero gene therapy using stem cells 83

Gene delivery to stem cells by artificial chromosome expression 83

Linker based sperm-mediated gene transfer technology 84

Combination of gene therapy with therapeutic cloning 84

Expansion of transduced HSCs in vivo 84

The future of hematopoietic stem cell gene therapy 85

Routes of administration for gene therapy 85

Direct injection of naked DNA 85

Intramuscular injection 86

Intravenous DNA injection 86

Intraarterial delivery 86

Companies with gene delivery devices/ technologies 86

Targeted gene therapy 88

Targeted integration 88

Bacteriophage integrase system for site-specific gene delivery 88

Controlled-release delivery of DNA 89

Controlled gene therapy 89

Controlled delivery of genetic material 89

Controlled induction of gene expression 90

Drug-inducible systems for control of gene expression 90

Timed activation of gene therapy by a circuit based on signaling network 91

Small molecules for post-transcriptional regulation of gene expression 91

Engineered zinc finger DNA binding proteins for gene correction 92

Light Activated Gene Therapy 92

Spatial control of gene expression via local hyperthermia 92

Companies with regulated /targeted gene therapy 92

Gene marking 94

Germline gene therapy 94

Potential applications of human germline genome modification 94

Pros and cons of human germline genome modification 95

Role of gene transfer in antibody therapy 96

Genetically engineered vaccines 96

DNA vaccines 96

DNA inoculation technology 97

Methods for enhancing the potency of DNA vaccines 97


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