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Reportlinker Adds Gene Therapy - technologies, markets and companies
Date:12/21/2010

ications of surface to improve gene delivery 60

Liposomes for gene therapy 61

Liposome-nucleic acid complexes 62

Liposome-HVJ complex 63

Transposons DNA vectors 63

Polycation-DNA complexes (polyplexes) 64

Plasmid DNA vector for treatment of chronic inflammatory disease 65

Polymer molecules 65

Synthetic biology and DNA vectors 65

Synthetic peptide complexes 66

Future prospects of nonviral vs viral vectors 66

Nanobiotechnology for gene therapy 66

Antisense nanoparticles for gene regulation 67

Biological nanoparticle technology 67

Dendrimers 67

Cochleates 67

Calcium phosphate nanoparticles as nonviral vectors 68

Gelatin nanoparticles for gene delivery 68

Lipid nanoparticles for nucleic acid delivery 69

Nanoparticles as nonviral vectors for gene therapy 69

Nanoparticles with virus-like function as gene therapy vectors 70

Nonionic polymeric micelles for oral gene delivery 70

Silica nanoparticles as a nonviral vector for gene delivery 70

Receptor-mediated endocytosis 71

Artificial viral vectors 72

Directed evolution of AAV to create efficient gene delivery vectors 72

Bacterial ghosts as DNA delivery systems 73

Bacteria plus nanoparticles for gene delivery into cells 73

Chromosome-based vectors for gene therapy 74

Companies using nonviral vectors 76

Concluding remarks about vectors 77

Cell-mediated gene therapy 78

Fibroblasts 78

Skeletal muscle cells 79

Vascular smooth muscle cells 79

Keratinocytes 80

Hepatocytes 80

Lymphocytes 80

Regulating protein delivery by genetically encoded lymphocytes 81

Implantation of microencapulated genetically modified cells 81

Stem cell gene therapy 82

Therapeutic applications for hematopoietic stem cell gene transfer 82

Improving delivery of genes to st
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