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Reportlinker Adds Gene Therapy - technologies, markets and companies
Date:12/21/2010

lar disorders 334

8. Gene therapy of viral infections 337

Introduction 337

Acquired Immunodeficiency Syndrome (AIDS) 337

Current management of AIDS 337

Gene therapy strategies in HIV/AIDS 338

HIV/AIDS vaccines 338

Insertion of protective genes into target cells. 339

Cell/gene therapies for HIV/AIDS 340

Transplantation of genetically modified T-cells 340

Transplantation of genetically modified hematopoietic cells 340

Anti-HIV ribozyme delivered in hematopoietic progenitor cells 341

Inhibition of HIV-1 replication by lentiviral vectors 341

VRX496 341

Intracellular immunization 342

Engineered cellular proteins such as soluble CD4s 342

Intracellular antibodies 342

Anti-rev single chain antibody fragment 342

Use of genes to chemosensitize HIV-1 infected cells 343

Autocrine interferon (INF)-b production by somatic cell gene therapy 343

Antisense approaches to AIDS 343

RNA decoys 343

Antisense oligodeoxynucleotides 343

RNA decoys 344

Ribozymes 344

RNAi applications in HIV/AIDS 345

siRNA-directed inhibition of HIV-1 infection 345

Role of the nef gene during HIV-1 infection and RNAi 345

Bispecific siRNA constructs 346

Targeting CXCR4 with siRNAs 346

Targeting CCR5 with siRNAs 346

Companies involved in developing gene therapy for HIV/AIDS 347

Conclusions regarding gene therapy of HIV/AIDS 348

Genetic vaccines for other viral infections 348

Cytomegalic virus infections 348

Viral hepatitis 349

Vaccine for hepatitis B virus 349

Vaccine for hepatitis C virus 350

Vaccine for herpes simplex virus 350

DNA vaccine against rabies 350

DNA vaccine for Ebola 351

Vaccines for avian influenza 351

Future prospects of DNA vaccines for avian influenza 352

Human trial of a DNA vaccine for avian inf
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