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Gene delivery by intrathecal route 303
Gene transfer for delivery of analgesics to the spinal nerve roots 303
Gene therapy of peripheral neuropathic pain 304
Gene transfer by injections into the brain substance 305
Targets for gene therapy of pain 305
Zinc finger DNA-binding protein therapeutic for chronic pain 305
Gene therapy for producing enkephalin to block pain signals 305
Targeting nuclear factor-kB 306
Gene therapy targeted to neuroimmune component of chronic pain 306
Potential applications of gene therapy for management of pain 306
Concluding remarks on gene therapy for pain 307
Gene therapy for psychiatric disorders 308
Gene therapy for depression 308
Gene therapy for enhancing cognition after stress 308
Gene therapy against fear disorders 309
Companies involved in gene therapy of neurological disorders 309
7. Gene Therapy of Cardiovascular Disorders 311
Introduction 311
Techniques of gene transfer to the cardiovascular system 311
Direct plasmid injection into the myocardium 312
Catheter-based systems for vector delivery 312
Ultrasound microbubbles for cardiovascular gene delivery 313
Vectors for cardiovascular gene therapy 313
Adenoviral vectors for cardiovascular diseases 313
Plasmid DNA-based delivery in cardiovascular disorders 313
Intravenous rAAV vectors for targeted delivery to the heart 314
Hypoxia-regulated gene therapy for myocardial ischemia 314
Angiogenesis and gene therapy of ischemic disorders 314
Therapeutic angiogenesis vs vascular growth factor therapy 315
Gene painting for delivery of targeted gene therapy to the heart 315
Gene delivery to vascular endothelium 316
Targeted plasmid DNA delivery to the cardiovascular system with nanoparticles 316
Vascular stents for gene delivery 316
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