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Reportlinker Adds Gene Therapy - technologies, markets and companies

expression in DMD 210

Repair of dystrophin gene 211

Routes of administration of gene therapy in DMD 211

Types of dystrophin constructs 211

Viral vectors for DMD 212

Conclusions and future prospects of gene therapy of DMD 213

Limb-girdle muscular dystrophy 214

Myotonic dystrophy 214

Spinal muscular atrophy 215

Antisense gene therapy of SMA 215

Hereditary neuropathies 215

Charcot-Marie-Tooth disease 215

Hereditary axonal neuropathies of the peripheral nerves 216

Gene therapy of mitochondrial disorders 216

Companies involved in gene therapy of genetic disorders 217

5. Gene Therapy of Cancer 219

Strategies for cancer gene therapy 219

Direct gene delivery to the tumor 220

Injection into tumor 220

Direct injection of adenoviral vectors 220

Direct injection of a plasmid DNA-liposome complex 221

A polymer approach to local gene therapy for cancer 221

Electroporation for cancer gene therapy 221

Control of gene expression in tumor by local heat 222

Radiation-guided gene therapy of cancer 222

Nanoparticles to facilitate combination of hyperthermia and gene therapy 223

Cell-based cancer gene therapy 223

Adoptive cell therapy 223

Cytokine gene therapy 224

Genetic modification of human hematopoietic stem cells 227

Immunogene therapy 227

Cancer vaccines 228

Genetically modified cancer cell vaccines 228

GVAX cancer vaccines 228

Genetically modified dendritic cells 229

Nucleic acid-based cancer vaccines 229

DNA cancer vaccines 230

RNA vaccines 230

Viral vector-based cancer vaccines 230

Intradermal delivery of cancer vaccines by Ad vectors 231

Future prospects of cancer vaccines 231

Companies involved in nucleic acid-based cancer vaccines 231

Monoclonal antibody gene transfer for cancer 232

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