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Gene therapy of genetic diseases affecting the liver 152
Crigler-Najjar syndrome 152
Hereditary tyrosinemia type I (HT1) 153
Hereditary tyrosinemia type 3 153
Gene therapy of acquired diseases affecting the liver 153
Cirrhosis of liver 153
Ophthalmic disorders 154
Introduction to gene therapy of ophthalmic disorders 154
Degenerative retinal disorders 155
Age-related macular degeneration 155
Inherited retinal degenerations 156
Inherited disorders affecting vision 157
Gene therapy for color blindness 157
Leber congenital amaurosis 157
Retinitis pigmentosa 158
Stargardt disease 159
Usher syndrome 159
X-linked juvenile retinoschisis 160
Proliferative retinopathies 160
Methods of gene transfer to retinal cells 160
DNA nanoparticles for nonviral gene transfer to the eye 161
Prevention of complications associated with eye surgery 162
Prevention of proliferative retinopathy by gene therapy 162
DNA nanoparticles for gene therapy of retinal degenerative disorders 162
Posterior capsule opacification after cataract surgery 162
Autoimmune uveitis 162
Retinal ischemic injury 163
Corneal disorders 163
Glaucoma 164
Disorders of hearing 164
Gene therapy for hearing loss 164
Organ transplantation 165
Introduction 165
DNA vaccines for transplantation 165
Gene therapy for prolonging allograft survival 165
Gene therapy in lung transplantation 166
Role of gene therapy in liver transplantation 166
Gene therapy in kidney transplantation 166
Veto cells and transplant tolerance 167
Pulmonary disorders 167
Techniques of gene delivery to the lungs 168
Adenoviral vectors 168
Non-viral vectors 169
Aerosolization as an aid to gene transfer to lungs. 169
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