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Reportlinker Adds Future Directions in Regenerative Medicine

e 15

Chapter 1 An introduction to regenerative medicine 17

Summary 17

Introduction 17

Cell-based therapies 18

Tissue engineering 19

Acellular therapies 20

Chapter 2 Allogeneic regenerative cell therapies 21

Summary 21

Introduction 21

Case studies 23

Advanced Cell Technology 24

Altrika 25

Athersys 26

BetaLogics 29

BioTime – embryonic progenitor cells 29

California Stem Cell 31

Cardio3 Biosciences 32

Celgene Cellular Therapeutics 33

Effector Cell Institute 33

Gamida Cell 34

Genzyme and Osiris Therapeutics 35

Geron 36

International Stem Cell 39

ISTO Technologies 40

MediStem – universal donor cells and cord blood transplants 41

Mesoblast – mesenchymal precursor cells 43

NeuralStem – fetal neural stem cells 45

Pfizer 46

Pluristem Therapeutics 47

Promethera Biosciences 49

Proteonomix 50

ReNeuron Group 50

Saneron CCEL Therapeutics. 51

Stematix 52

StemCells 52

Stemedica Cell Technologies 54

Stempeutics Research 55

TiGenix – allogeneic MSCs 55

TissueGene 56

Summary of allogeneic cell therapies in development 57

Discussion 63

Technical issues 63

Regulatory issues 66

Logistical issues 66

Conclusions 67

Chapter 3 Autologous regenerative cell therapies 69

Summary 69

Introduction 69

Case studies 71

Aastrom Biosciences 72

Aldagen 72

American Medical Systems Holdings 75

Amorcyte 75

Azellon 75

Bioheart 76

BioTime – induced pluripotent stem cells 77

BrainStorm Cell Therapeutics 79

Cytori Therapeutics 80

Ectycell 81

GeneGrafts 82

GlaxoSmithKline 83

Intercytex 84

LoneStar Heart – regenerative cell induction 86'/>"/>

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