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Reportlinker Adds Downstream Processing in Biopharmaceuticals - Increased Demand for Biologics Drives Improvement in Cost -effective Purification Technologies
Date:10/19/2010

A Typical Downstream Processing: 13

3.2.2 Major Check Point during Down Stream Processing 14

3.3 Overview of Downstream Industry 15

4 Downstream Processing : Role of Downstream Processing in the Biopharmaceutical Industry 16

4.1 Comparison of Upstream Processing and Downstream Processing 18

4.2 Major Reagents, Reagent Suppliers and Reagent Market Related To Downstream Processing 19

4.2.1 Major Reagents 19

4.2.2 Reagent Suppliers 20

4.2.3 Reagent Market 22

4.3 Major Equipment Suppliers 26

5 Downstream Processing: Downstream Processing Market for CMOs 27

5.1 Global CMO Market Overview 27

5.2 CMO Biopharmaceuticals Market Characterization 27

5.3 CMO Market Size for Downstream Processing 29

6 Downstream Processing : Challenges and Unmet Needs in Downstream Bioprocess 30

6.1 Challenges 30

6.1.1 Chromatographic Capture 30

6.1.2 Reducing the Purification Steps 30

6.1.3 Titer increment /Capacity Bottleneck 31

6.1.4 Virus Clearances 31

6.1.5 Scaling –Up 31

6.2 Unmet Needs 32

6.2.1 Unmet Medical Needs 32

6.2.2 Realistic Achievement of Economies of Scale 33

6.2.3 Technological Development of Disposables at Large Scale 34

6.2.4 Reagent Cost and Their Effectiveness 35

7 Downstream Processing : Emerging Technologies and their Implication 36

7.1 Disposable Technology / Single Use Technology 36

7.1.1 Use of Single Use Technology in Downstream Operations 39

7.1.2 Major Benefits of Single use Technology 40

7.1.3 Major Challenges in Single Use Technology 41

7.1.4 Some Recent Products Developed By Major Firms 42

7.2 Membrane Chromatography 42

7.3 Multi-Column Chromatography 44

7.3.1 Advantages 44

7.3.2 Drawbacks 44

7.3.3 Applications 45

7.4 Aqueous Two Phase System 45

7.5 Tangential Flow Filtration 45

7.5.1 Tan
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