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Reportlinker Adds Biomarkers - Technologies, Markets And Companies

al-time PCR for expression profiling of miRNAs .. 94

Use of LNA to explore miRNA 94

Microarrays for analysis of miRNA gene expression .. 94

4. Biomarkers for Drug Discovery & Development 96

Introduction . 96

Biomarker technologies for drug discovery 97

Proteomics-based biomarkers for drug discovery .. 97

Chemoproteomics 97

Activity-based chemical proteomics . 97

Transcriptomics for drug discovery . 98

Metabolomics for drug discovery . 98

Biomarkers and drug safety .. 99

Biomarkers of adverse drug reactions 99

Applications of biomarkers in drug safety studies .. 99

Genomic technologies for toxicology biomarkers . 100

Proteomic technologies for toxicology biomarkers .. 100

Metabonomic technologies for toxicology biomarkers . 101

Integration of genomic and metabonomic data to develop toxicity biomarkers .. 101

Toxicology studies based on biomarkers 101

Biomarkers of hepatotoxicity .. 102

Biomarkers of nephrotoxicity .. 103

Cardiotoxicity .. 104

Neurotoxicity 105

Applications of biomarkers for drug development .. 106

Application of metabonomics/metabolomics for drug development 106

Role of pharmacokinetic/pharmacodynamic biomarkers in drug development 106

Molecular imaging as a biomarker in drug development 107

Molecular imaging in preclinical studies 107

Molecular imaging in clinical trials . 108

Prospects of molecular imaging in drug discovery and development .. 109

Biomarkers in clinical trials . 109 - 6 -

NIH recommendations on the use of biomarkers in clinical trials . 110

Advantages of biomarkers for drug development . 111

Limitations and problems with use of biomarkers in clinical trials 112

Application of biomarkers by the pharmaceutical companies 112

Use of biomarkers in relation to

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