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e . 174

6. Biomarkers of Cancer . 176

Introduction .. 176

The ideal biomarker for cancer . 176

Single vs multiple biomarkers of cancer . 177

Types of cancer biomarkers 177

HER3 as biomarker of cancer . 178

DNA repair biomarkers 178

miRNAs as biomarkers in cancer .. 178

Circulating miRNAs for cancer detection .. 180

Diagnostic value of miRNA in cancer . 180

Biomarkers of epigenetic gene silencing in cancer .. 180

Immunologic biomarkers of cancer .. 181

Molecular diagnostic techniques for cancer 181

Technologies for detection of cancer biomarkers . 182

Genomic technologies for cancer biomarkers 182

Cold-PCR .. 182

Genome analysis at the molecular level .. 183

Sequencing-based approaches for detection of cancer biomarkers .. 183

Early detection of tumor suppressor gene mutations .. 183

Biomarkers of PTEN tumor suppressor gene status .. 184

HAAH as a biomarker for cancer 184

KRAS as a biomarker of cancer .. 185

Telomerase as a biomarker of cancer .. 185

Digital karyotyping for cancer biomarkers .. 185

LigAmp for detection of gene mutations in cancer 186

Mitochondrial DNA as a cancer biomarker 186

Tissue microarrays for study of cancer biomarkers . 186

Molecular fingerprinting of cancer 187

Biomarkers of inflammation in cancer . 188

Proteomic technologies for detecting biomarkers of cancer .. 188

2D PAGE 189

Antibody-based detection of protein biomarkers .. 189

Aptamer-based molecular probes for cancer biomarker discovery 190

Cancer immunomics to identify autoantibody signatures 190

Desorption electrospray ionization for detection of cancer biomarkers 191

Detection of circulating nucleosomes in serum of cancer patients 191

Detection of tumor markers with ProteinChip technology ..

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