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Reovirus Infection of Melanoma Cells Generates Anti-Tumour Immunity
Date:9/11/2007

Oncolytics Biotech Inc. Collaborators to Present Research at National

Cancer Research Institute Conference

CALGARY, Sept. 12 /PRNewswire-FirstCall/ - Oncolytics Biotech Inc. ("Oncolytics") (TSX:ONC, NASDAQ:ONCY) announced today that Dr. Robin Prestwich of CR-UK Clinical Centre, Leeds Institute of Molecular Medicine, University of Leeds, U.K. is scheduled to deliver a poster presentation on Tuesday, October 2, 2007 at the NCRI Cancer Conference entitled "Reovirus Infection of Human Melanoma Cells Supports Priming of Anti-Tumour Cytotoxic T Cell Immunity." The conference runs from September 30 through October 3, 2007 in Birmingham, U.K.

In this study, the investigators infected melanoma cell lines with reovirus. The reovirus-infected cell lines stimulated the maturation of dendritic cells, which in turn educated cancer-killing T cells to attack and kill the melanoma cells.

"Despite widespread interest in the anti-tumour effects of oncolytic viruses, little attention has been focused upon their potential to generate anti-tumour immunity," said Professor Alan Melcher of St. James's University Hospital in Leeds, U.K. and a co-investigator of this preclinical study. "This work has demonstrated for the first time the stimulatory effect of reovirus-infected melanoma cells on dendritic cells and their superiority over uninfected cells as an antigen source for bystander priming of anti-tumour immunity."

The research will be posted on the Oncolytics website at http://www.oncolyticsbiotech.com as soon as it is available.

About Oncolytics Biotech Inc.

Oncolytics is a Calgary-based biotechnology company focused on the development of oncolytic viruses as potential cancer therapeutics. Oncolytics' clinical program includes a variety of Phase I and Phase II human trials using REOLYSIN(R), its proprietary formulation of the human reovirus, alone and in combina
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SOURCE Oncolytics Biotech Inc.
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