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Regado Biosciences, Inc. Presents Positive Efficacy and Safety Substudy Data from the Phase 2b RADAR Trial for the REG1 Anticoagulation System at the Transcatheter Cardiovascular Therapeutics (TCT) Symposium 2011
Date:11/7/2011

BASKING RIDGE, N.J., Nov. 7, 2011 /PRNewswire/ -- Regado Biosciences, Inc., a privately held company leading the development of antithrombotic aptamers with active control agents, announced the presentation of two posters highlighting positive substudy results of the Company's Phase 2b RADAR trial of REG1, Regado's proprietary anticoagulation system.  The posters will be presented at the Transcatheter Cardiovascular Therapeutics (TCT) Symposium meeting on November 8, 2011 from 8:00-10:00 a.m. PST in San Francisco, CA.  

"The Phase 2b RADAR trial for REG1 has demonstrated a paradigm shift to provide physicians with a more effective option to control bleeding and ischemic events in ACS patients.  REG1 provides physicians the ability to titrate the intensity of anticoagulation according to specific patient needs, which are not currently met with existing drugs," said Dr. Mauricio Cohen, director of the cardiac catheterization laboratory at the University of Miami Miller School of Medicine and a lead investigator of the study, who will present the data.  "We're delighted to have the opportunity to share further analyses of these groundbreaking results among our peers."

The posters are titled "Use of the REG1 Anticoagulation System During PCI May Improve Bleeding and Ischemic Complications Compared with Heparin: A PCI Substudy from the Phase 2b RADAR Trial" and "Access and non-Access Site Bleeding in Acute Coronary Syndrome Patients Treated with a Novel Actively Reversible Factor IXa Inhibitor: Results from the RADAR Trial."

REG1 is a two-component system consisting of pegnivacogin (a.k.a. RB006), a direct Factor IXa inhibitor, and anivamersen (a.k.a. RB007), its complementary active control agent.  The RADAR clinical trial demonstrated that REG1 provided nearly complete Factor IXa inhibition followed by 75% and 100% reversal, resulting in numerically lower rates of ischemic events when compared with heparin.  The res
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