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Receptos Scientists Publish Determination of a High Resolution Sphingosine 1-Phosphate Receptor 1 Structure in Science
Date:2/16/2012

SAN DIEGO, Feb. 16, 2012 /PRNewswire/ -- Receptos Inc. announced today the publication of key results relating to its expertise in S1P1 biology and structure-based drug discovery for high-value G-protein-coupled receptor (GPCR) targets in Science.

The article, entitled "Crystal Structure of a Lipid G Protein-Coupled Receptor," was co-authored by Receptos in collaboration with scientific founders Hugh Rosen, M.D., Ph.D., and Raymond Stevens, Ph.D. Drs. Rosen and Stevens are both professors at The Scripps Research Institute®, with expertise in immunology and lymphocyte trafficking and GPCR crystallography, respectively. Receptos is the exclusive licensee of the GPCR crystal structure determination technology platform, developed at The Scripps Research Institute®, which enabled the elucidation of the S1P1 receptor structure.

"Receptos and its founders have an unparalleled track record in the determination of high resolution GPCR structures to enable rational drug design," said Faheem Hasnain, President and Chief Executive Officer of Receptos. "The publication of the S1P1 structure in Science highlights the importance of this therapeutic target and Receptos's leading position in decoding receptor-ligand interactions for pharmaceutically relevant GPCR targets. Our expertise in the S1P1 field has resulted in the discovery of a best-in-class small molecule agonist, RPC1063, which is scheduled to initiate Phase 2 clinical studies in multiple sclerosis and inflammatory bowel disease later this year."

Receptos utilizes the GPCR crystal structure determination technology platform to assist in building a pipeline of high-value therapeutic candidates. In addition to RPC1063, the technology supports a small molecule glucagon-like peptide 1 (GLP1) research program, which has demonstrated proof of concept in in vivo models of type 2 diabetes. Receptos has also initiated technology collaborations to c
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