Navigation Links
Receptos Co-Publishes Highest Resolution G-Protein Coupled Receptor Structure to Date in Science
Date:7/12/2012

SAN DIEGO, July 13, 2012 /PRNewswire/ -- Receptos Inc. announced today the co-publication, in conjunction with the Stevens Lab at The Scripps Research Institute®, of key results relating to its expertise in the determination of high resolution G-protein coupled receptor (GPCR) crystal structures to enable rational drug discovery and design, including for allosteric modulators of GPCR receptors.

The article, published in today's issue of Science and titled "Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions," reveals a 1.8 angstrom resolution structure of the human adenosine 2A (A2A) receptor, including a potentially family-conserved allosteric binding site. The A2A receptor is expressed in the brain, has important roles in the regulation of glutamate and dopamine release and is a potential therapeutic target for the treatment of conditions such as Parkinson's disease and depression. Receptos is the exclusive licensee of the GPCR crystal structure determination technology platform and, together with scientific founder Raymond Stevens, Ph.D., and The Scripps Research Institute, has an unparalleled publication record that includes the identification of 15 distinct structures of eight unique receptors over the last five years.

"Today's publication of the highest resolution GPCR structure identified to date, as well as the discovery of a previously unknown allosteric binding site, reaffirms that Receptos has a best-in-class structural biology platform to address drug discovery for this important target class," said Faheem Hasnain, President and Chief Executive Officer of Receptos. "The novel biophysical screening techniques integral to our technology platform also assisted in the initial identification of allosteric modulators for our promising small molecule Glucagon-like peptide-1 (GLP-1) program for Type 2 diabetes."

The Receptos GPCR drug discovery platform is differentiated to allow rapid generation of
'/>"/>

SOURCE Receptos Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. Receptos to Present at the Cowen and Company 32nd Annual Health Care Conference
2. Receptos Scientists Publish Determination of a High Resolution Sphingosine 1-Phosphate Receptor 1 Structure in Science
3. Receptos and Ono Establish Collaboration with Focus on Bioactive Lipid Discovery Research
4. CSL Behring Study Confirms Early Treatment with Berinert® Provides Faster Resolution of Acute Hereditary Angioedema Symptoms
5. Gated STED -- developing the next generation of super-resolution microscopes
6. Cord Blood America Announces Agreement To Restructure Debt
7. X-ray vision exposes aerosol structures
8. Study shows availability of hydrogen controls chemical structure of graphene oxide
9. In metallic glasses, researchers find a few new atomic structures
10. New technique uses electrons to map nanoparticle atomic structures
11. Bio-inspired polymer synthesis enhances structure control
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/20/2014)... 20, 2014 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ("Biorem" or "the ... Q3 orders to $5.8 million and provides a good start to ... North America and one in the ... projects at record levels," said Peter Bruijns , President & ... end of Q3 than they have been for any complete year ...
(Date:10/20/2014)... Earle Martin , Chief Executive ... Ellen Teplitzky, an experienced attorney specializing in business ... has joined the firm as Director of Legal ... NDA Partners provides legal services, including research, ... top law firms and their clients in cases ...
(Date:10/19/2014)... The Asia-Pacific Bromine Market report defines and ... and forecast of revenue. , Browse through the ... to get an idea of the in-depth analysis ... segmentation in the Asia-Pacific bromine market, and is ... http://www.micromarketmonitor.com/market/asia-pacific-bromine-6741503144.html , Bromine is a volatile ...
(Date:10/19/2014)... The report "Unmanned Ground Vehicle Market by ... Type & by Geography - Forecasts & Analysis ... vehicle market into various sub segments with an ... report also identifies the factors driving this market, ... the adoption trends. , The unmanned ground vehicle ...
Breaking Biology Technology:NDA Partners Appoints Ellen Teplitzky, JD as Director of its Legal Services Practice 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 3Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 2Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 3Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 4Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 5
... Mass., May 11 Boston Scientific Corporation (NYSE: ... Company,s major events and news announcements at the 30th ... run from May 13 to 16 in Boston. ... from the MADIT II clinical trial and the ALTITUDE ...
... VANCOUVER, May 11 /PRNewswire-FirstCall/ - OncoGenex Pharmaceuticals, Inc. ... final survival data from a randomized Phase 2 ... docetaxel alone as first-line chemotherapy in patients with ... an oral presentation at the American Society of ...
... 11 Dalton Pharma Services and ProCitius Research jointly ... contract chemistry services of exceptional ... their discovery and development output in an era of ... "offshore" contract research organizations (CROs) ...
Cached Biology Technology:Boston Scientific Announces Company Schedule for Heart Rhythm Society Scientific Sessions 2Boston Scientific Announces Company Schedule for Heart Rhythm Society Scientific Sessions 3Boston Scientific Announces Company Schedule for Heart Rhythm Society Scientific Sessions 4Boston Scientific Announces Company Schedule for Heart Rhythm Society Scientific Sessions 5OncoGenex Pharmaceuticals' Clinical Programs to be Featured in Oral Presentations at the American Society of Clinical Oncology Annual Meeting 2OncoGenex Pharmaceuticals' Clinical Programs to be Featured in Oral Presentations at the American Society of Clinical Oncology Annual Meeting 3Dalton Pharma Services and ProCitius Announce a Strategic Alliance to Provide Contract Chemistry Services 2Dalton Pharma Services and ProCitius Announce a Strategic Alliance to Provide Contract Chemistry Services 3
(Date:10/17/2014)... release is available in German . ... of sperms every day in order to reproduce? And why ... the topic of the latest issue of the research journal ... The evolutionary biologist Steven Ramm from Bielefeld University Bielefeld has ... is not unusual for a female to copulate with several ...
(Date:10/16/2014)... Institute of Marine Science have received a 3-year, ... identify the streams and wetlands most vulnerable to ... local governments and citizens conserve these important ecosystems. ... of tidal-marsh observations first gathered by VIMS scientists ... can today,s researchers accurately map the slow but ...
(Date:10/16/2014)... infections and worldwide claims the lives of 160,000 ... University have succeeded in developing a promising vaccination ... , Xavier Saelens (VIB/UGent): "We discovered a new ... development of a novel approach to vaccination against ... small children and elderly people." , RSV: ...
Breaking Biology News(10 mins):Sperm wars 2EPA grant will help localities conserve headwater wetlands 2EPA grant will help localities conserve headwater wetlands 3New perspectives for development of an RSV vaccine 2
... have developed a computer-aided method that uses electronic ... advances toward personalized health care, disease management and ... Chawla and his doctoral student, Darcy A. Davis, ... Engine (CARE) for personalized disease risk predictions and ...
... A forest full of rabbits and foxes, a bubbling ... a cell are, to a computer, similar systems: Many ... of rules and individual interactions that can,t be precisely ... pathways, or rabbits multiplying or getting eaten. Predicting ...
... WA, and Ahmedabad, India, July 25, 2013: In ... group and an innovation-led global healthcare provider, and ... organization, announced today they are collaborating on the ... (VL) vaccine candidate, designed to prevent the deadly ...
Cached Biology News:Notre Dame researchers develop system that uses a big data approach to personalized healthcare 2Computer can infer rules of the forest 2IDRI and Zydus sign agreement for development of IDRI's vaccine candidate for visceral leishmaniasis 2
... The GSTTag Monoclonal Antibody is a ... affinity to the 26 kDa glutathione-S-transferase ... This purified antibody is suitable for ... sequence expressed in E. coli , ...
... LNA microarray slides for microRNA expression ... incorporate Exiqons unique Locked Nucleic Acid (LNA) ... mismatch discrimination for short microRNA (miRNA) targets. ... 1 g total RNA (no need for ...
... there have been many modifications to the original ... salt solutions still play an important role in ... the pH and osmotic balance in the medium ... essential inorganic ions, is as valuable today as ...
Imject Freund's Complete Adjuvant (FCA)...
Biology Products: