Navigation Links
Receptos Co-Publishes Highest Resolution G-Protein Coupled Receptor Structure to Date in Science

SAN DIEGO, July 13, 2012 /PRNewswire/ -- Receptos Inc. announced today the co-publication, in conjunction with the Stevens Lab at The Scripps Research Institute®, of key results relating to its expertise in the determination of high resolution G-protein coupled receptor (GPCR) crystal structures to enable rational drug discovery and design, including for allosteric modulators of GPCR receptors.

The article, published in today's issue of Science and titled "Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions," reveals a 1.8 angstrom resolution structure of the human adenosine 2A (A2A) receptor, including a potentially family-conserved allosteric binding site. The A2A receptor is expressed in the brain, has important roles in the regulation of glutamate and dopamine release and is a potential therapeutic target for the treatment of conditions such as Parkinson's disease and depression. Receptos is the exclusive licensee of the GPCR crystal structure determination technology platform and, together with scientific founder Raymond Stevens, Ph.D., and The Scripps Research Institute, has an unparalleled publication record that includes the identification of 15 distinct structures of eight unique receptors over the last five years.

"Today's publication of the highest resolution GPCR structure identified to date, as well as the discovery of a previously unknown allosteric binding site, reaffirms that Receptos has a best-in-class structural biology platform to address drug discovery for this important target class," said Faheem Hasnain, President and Chief Executive Officer of Receptos. "The novel biophysical screening techniques integral to our technology platform also assisted in the initial identification of allosteric modulators for our promising small molecule Glucagon-like peptide-1 (GLP-1) program for Type 2 diabetes."

The Receptos GPCR drug discovery platform is differentiated to allow rapid generation of functional, stabilized target protein in as little as four months. In addition to crystal structure determination, this protein can be used in a variety of screening modes allowing identification of novel small molecule chemotypes or as antigen for the generation of therapeutic antibody candidates. The collaborative efforts of Receptos and The Scripps Research Institute have also resulted in significant advancements in protein engineering and the availability of a growing panel of proprietary, validated fusion proteins that enable crystallization of near wild-type GPCR domains. These successes are expanding the breadth of GPCR targets that are amenable to structure determination, including previously intractable targets.

Receptos has a broad patent estate comprised of 12 patent applications, seven of which are directed to small molecule composition of matter and four of which support the technology platform, including novel reagents to enable crystallography. Receptos has initiated three technology collaborations to conduct novel drug screening assays and study dynamic conformational changes to receptor topography that allow rational drug design for high‐value GPCR targets. Receptos is also pursuing new applications for the platform technology in the discovery and development of therapeutic antibody candidates directed to GPCR receptors.

About Receptos
Receptos is a biopharmaceutical company developing autoimmune therapeutic candidates through information-driven drug discovery, including GPCR structure determination. The company's lead program, RPC1063, is a best‐in‐class S1P1 small molecule agonist candidate for autoimmune indications. Receptos has completed a Phase 1 clinical safety study with RPC1063 under a US IND that supports the desired differentiation profile and establishes justification for initiation of multiple sclerosis and inflammatory bowel disease clinical efficacy trials in 2012. Receptos' expertise in S1P1 biology has been informed by the company's high resolution protein crystal structure of the S1P1 receptor, published in Science earlier this year. Receptos has established partnerships for its GPCR structure determination technology platform with Eli Lilly, Ono Pharmaceutical and Janssen Pharmaceuticals, Inc. For more information visit

Media and Investor Contacts:
Russo Partners
Ian Stone or David Schull
(619) 308-6541 or (212) 845-4271

SOURCE Receptos Inc.
Copyright©2012 PR Newswire.
All rights reserved

Related biology technology :

1. Receptos to Present at the Cowen and Company 32nd Annual Health Care Conference
2. Receptos Scientists Publish Determination of a High Resolution Sphingosine 1-Phosphate Receptor 1 Structure in Science
3. Receptos and Ono Establish Collaboration with Focus on Bioactive Lipid Discovery Research
4. CSL Behring Study Confirms Early Treatment with Berinert® Provides Faster Resolution of Acute Hereditary Angioedema Symptoms
5. Gated STED -- developing the next generation of super-resolution microscopes
6. Cord Blood America Announces Agreement To Restructure Debt
7. X-ray vision exposes aerosol structures
8. Study shows availability of hydrogen controls chemical structure of graphene oxide
9. In metallic glasses, researchers find a few new atomic structures
10. New technique uses electrons to map nanoparticle atomic structures
11. Bio-inspired polymer synthesis enhances structure control
Post Your Comments:
(Date:11/25/2015)... SAN DIEGO , Nov. 25, 2015  Neurocrine ... Kevin Gorman , President and CEO of Neurocrine ... Jaffray Healthcare Conference in New York ... encouraged to visit the website approximately 5 minutes prior ... software.  A replay of the presentation will be available ...
(Date:11/25/2015)... , November 25, 2015 ... Report is a professional and in-depth study on ...      (Logo: ) , ... the industry including definitions, classifications, applications and industry ... for the international markets including development trends, competitive ...
(Date:11/24/2015)... , Nov. 24, 2015 Cepheid (NASDAQ: ... speaking at the following conference, and invited investors to ... NY      Tuesday, December 1, 2015 at 11.00 ... NY      Tuesday, December 1, 2015 at 11.00 ... Conference, New York, NY      Tuesday, ...
(Date:11/24/2015)... ... November 24, 2015 , ... International Society for Pharmaceutical Engineering ... premier annual events for pharmaceutical manufacturing: 2015 Annual Meeting. The conference took place ... the largest number of attendees in more than a decade. , “The ...
Breaking Biology Technology:
(Date:10/29/2015)... ANN ARBOR, Mich. , Oct. 29, 2015 ... with Eurofins Genomics for U.S. distribution of its ... DNA-seq kit and Rubicon,s new ThruPLEX Plasma-seq ... DNA to enable the preparation of NGS libraries ... in plasma for diagnostic and prognostic applications in ...
(Date:10/29/2015)... 29, 2015 Today, LifeBEAM , ... with 2XU, a global leader in technical performance ... hat with advanced bio-sensing technology. The hat will ... monitor key biometrics to improve overall training performance. ... two companies will bring together the most advanced technology, ...
(Date:10/27/2015)... Calif. , Oct. 27, 2015 Synaptics Inc. ... solutions, today announced that Google has adopted the Synaptics ... touch controller solutions to power its newest flagship smartphones, ... by Huawei. --> ... like Google to provide strategic collaboration in the joint ...
Breaking Biology News(10 mins):