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Receptos Co-Publishes Highest Resolution G-Protein Coupled Receptor Structure to Date in Science
Date:7/12/2012

SAN DIEGO, July 13, 2012 /PRNewswire/ -- Receptos Inc. announced today the co-publication, in conjunction with the Stevens Lab at The Scripps Research Institute®, of key results relating to its expertise in the determination of high resolution G-protein coupled receptor (GPCR) crystal structures to enable rational drug discovery and design, including for allosteric modulators of GPCR receptors.

The article, published in today's issue of Science and titled "Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions," reveals a 1.8 angstrom resolution structure of the human adenosine 2A (A2A) receptor, including a potentially family-conserved allosteric binding site. The A2A receptor is expressed in the brain, has important roles in the regulation of glutamate and dopamine release and is a potential therapeutic target for the treatment of conditions such as Parkinson's disease and depression. Receptos is the exclusive licensee of the GPCR crystal structure determination technology platform and, together with scientific founder Raymond Stevens, Ph.D., and The Scripps Research Institute, has an unparalleled publication record that includes the identification of 15 distinct structures of eight unique receptors over the last five years.

"Today's publication of the highest resolution GPCR structure identified to date, as well as the discovery of a previously unknown allosteric binding site, reaffirms that Receptos has a best-in-class structural biology platform to address drug discovery for this important target class," said Faheem Hasnain, President and Chief Executive Officer of Receptos. "The novel biophysical screening techniques integral to our technology platform also assisted in the initial identification of allosteric modulators for our promising small molecule Glucagon-like peptide-1 (GLP-1) program for Type 2 diabetes."

The Receptos GPCR drug discovery platform is differentiated to allow rapid generation of
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SOURCE Receptos Inc.
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