Navigation Links
ReceptorBio Announces Diabetes License Agreement With Telik

FOSTER CITY, Calif., Aug. 19 /PRNewswire-FirstCall/ -- ReceptorBio, Inc. announced today that it has entered into a license agreement with Telik, Inc. (Palo Alto, CA) (Nasdaq: TELK) that would enable ReceptorBio to develop and commercialize Telik's unique, oral small molecule insulin receptor activators. These compounds were identified through the application of TRAP(R), Telik's proprietary drug discovery technology. The agreement provides for payments related to regulatory milestones and royalties based on product sales.

Pre-clinical testing has indicated that these insulin receptor activators, as single agents, lower glucose levels in models of diabetes. The compounds are active in the presence of sub-maximal levels of insulin, and do not cause hypoglycemia at the dose levels examined. This synergy with insulin suggests the compounds could potentially be co-administered with other anti-diabetic agents including insulin. The insulin receptor activating activity of these compounds suggests that they may be attractive drug candidates for advancing the treatment of Type 2 diabetes mellitus (T2D) and the Insulin Resistance/Metabolic Syndrome (Journal of Biological Chemistry (2002), 277, 43565-43571).

"ReceptorBio is very enthusiastic about gaining the opportunity to continue the development of the insulin receptor activator compounds discovered by Telik," said Joseph Evans, Ph.D., ReceptorBio's Co-founder and President. "These compounds have a unique mechanism of action directed against a validated drug target, the insulin receptor, and thus they represent a novel class of insulin sensitizers."

"The oral agents currently available on the market for the treatment of T2D are limited, and may be associated with undesirable side effects," added David Klonoff, M.D., ReceptorBio's Co-founder and Chairman of its Clinical Advisory Board. "A drug that acts by targeting and activating the insulin receptor should provide a novel treatment for this disease, both as a single agent, and in combination with other drugs that have complimentary mechanisms of action."

ReceptorBio, Inc. is an early stage biopharmaceutical company located in Foster City, CA with plans to develop orally active pharmaceuticals for the treatment of T2D and related diseases including obesity, and the insulin resistance/metabolic syndrome which has been associated with a markedly increased risk of cardiovascular disease. The Company's initial focus will be on the clinical development of its lead compound, RB101, believed to activate the insulin receptor tyrosine kinase (IRTK), a recognized drug target for T2D. IRTK activation is one of the early signaling events required to mediate insulin's physiologically effects on glycemic control. Currently, there are no FDA-approved drugs that have this mechanism of action. ReceptorBio believes its novel agents are thus positioned to be first in their class, with a mechanism of action that may be compatible for use both as a single agent and in combination with existing medications for T2D.

The founders and management team of ReceptorBio have a long and successful history of accomplishments in T2D research and drug development. Joseph L. Evans, Ph.D., ReceptorBio President, has over twenty years experience in the research, development, and pharmacology of therapeutics for T2D and obesity, including positions of increasing responsibility in drug discovery and development at Sandoz (now Novartis), Shaman, SUGEN, Telik, and Leptogen. David Klonoff, M.D., FACP, ReceptorBio Director and Chairman of the Clinical Advisory Board, is a Clinical Professor of Medicine at the University of California, San Francisco. In addition, Dr. Klonoff is Medical Director of the Dorothy L. and James E. Frank Diabetes Research Institute of Mills-Peninsula Health Services (San Mateo, CA). Dr. Klonoff is the founding editor-in-chief of Journal of Diabetes Science and Technology, published by the Diabetes Technology Society, also founded by Dr. Klonoff. Dr Klonoff is also a Medical Officer of the U.S. Army Telemedicine and Advanced Technology Research Center in the areas of biosensors and physiologic monitoring. Ira D. Goldfine, M.D., FACP, Chairman of the Scientific Advisory Board, is a Professor of Medicine and Physiology at the University of California at San Francisco. He is also Director of Diabetes and Endocrine Research at Mt. Zion Hospital (San Francisco, CA). His research focuses on the molecular basis of T2D, and he has been a pioneer in the area of identifying new agents that activate the IRTK. Dr. Goldfine has received the Rosenthal Award from American College of Physicians and the Mount Zion Distinguished Alumni Award. Dr. Goldfine is past president of the American Diabetes Association, Western Region.

SOURCE ReceptorBio, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Related biology technology :

1. Lixte Biotechnology Holdings Announces Filing of a New Patent Application for Cancer Therapy Based on Targeting a Biomarker by Novel Investigational Agents
2. ArunA Biomedical Announces Exclusive Worldwide Technology Licensing Agreement to Commercialize Human Embryonic Stem Cell Derived Mesenchymal Cells
3. Arno Therapeutics Announces Second Quarter 2008 Financial Results
4. 4C Controls Announces the Appointment of Dr. Philip Hayden as Vice President, Security Assessment & Threat Analysis
5. Logical Therapeutics Inc. Announces Results of Phase 1b Clinical Study of its Naproxen Prodrug
6. Lotus Pharmaceuticals Announces Second Quarter 2008 Results
7. Yongye Biotechnology International Announces Second Quarter Results
8. China Kangtai Cactus Biotech Announces Record Second Quarter Results
9. AMDL Inc. Announces Second Quarter 2008 Results; Company Posts $5.8 Million in Sales With a Revenue Increase of 140%
10. CV Therapeutics Announces Ranexa(R) Named Finalist for Prix Galien USA 2008 Award
11. Arno Therapeutics Announces Appointment of Brian Lenz, CPA as Chief Financial Officer
Post Your Comments:
(Date:10/12/2015)... SAN DIEGO , Oct. 12, 2015 /PRNewswire/ ... for debilitating allergic and inflammatory diseases and conditions, ... Series A preferred stock financing. Concurrent with the ... also entered into a Loan and Security Agreement ... borrow up to $7 million. Patara will use ...
(Date:10/12/2015)... Oct. 12, 2015 VolitionRx Limited (NYSE ... clinical study of its NuQ ® blood-based test for ... issue of Clinical Epigenetics , the official journal of ... collaboration with Lund University, ... MD, PhD, Professor of Surgery and Vice-Dean, Faculty of Medicine. ...
(Date:10/12/2015)... , ... October 12, 2015 , ... LifeTrak , ... launch of LifeTrak Zoom, the world’s first amphibious fitness tracker that seeks to meet ... flexwear technology and accurate heart rate monitoring both in water and on ...
(Date:10/10/2015)... 2015 Am 8. Oktober hat die ... für Kalifornien) ihre Würdigung der International Plasma Awareness ... Aufzeichnungen des Kongresses eintragen lassen. Die IPAW wird ... (PPTA) und ihren Mitgliedsunternehmen unterstützt. Ihre Ziele bestehen ... über Plasmaspenden weltweit , Würdigung des Beitrages ...
Breaking Biology Technology:
(Date:10/8/2015)... , 8. Oktober 2015 ... global tätiges Unternehmen des Bereiches Tracking, hat ... mit der Gefängnisbehörde Virginias (Department of Corrections ... elektronische Überwachungsdienste für alle Strafen geliefert werden, ... Cassell , Präsident für den Amerikanischen Kontinent ...
(Date:10/6/2015)... SAN MATEO, Calif. , Oct. 6, 2015 ... software company, today announced enhancements to its software ... gene expression analysis kit for differential expression in ... Analytic Platform, which is a cloud-based genomic analysis ... to advance scientific discovery from next-generation sequencing efforts. ...
(Date:9/30/2015)... 2015  The U.S. Court of Appeals for the ... in favor of Crossmatch ™, affirming the International ... Suprema and its U.S. partner Mentalix violated Section 337 ... that declares it unlawful to engage in "unfair practices" ... Crossmatch,s patents, the 5,900,993 patent and the 7,203,344 patent. ...
Breaking Biology News(10 mins):