Navigation Links
Real-time observation of the DNA-repair mechanism
Date:5/22/2008

For the first time, researchers at Delft University of Technology have witnessed the spontaneous repair of damage to DNA molecules in real time. They observed this at the level of a single DNA molecule. Insight into this type of repair mechanism is essential as errors in this process can lead to the development of cancerous cells. Researchers from the Kavli Institute of Nanoscience Delft are to publish an article on this in the leading scientific journal Molecular Cell.

Cells have mechanisms for repairing the continuous accidental damage occurring in DNA. These damages can vary from a change to a single part of the DNA to a total break in the DNA structure. These breaks can, for instance, be caused by ultraviolet light or X-rays, but also occur during cell division, when DNA molecules split and form two new DNA molecules. If this type of break is not properly repaired it can be highly dangerous to the functioning of the cell and lead to the creation of a cancerous cell.

One major DNA-repair mechanism involved in repairing these breaks is known as homologous recombination. This mechanism has been observed for the first time by Delft University of Technology researchers in real time and at the level of a single DNA molecule.

To observe this, a DNA molecule is stretched between a magnetic bead and a glass surface. A force is exerted on the magnetic bead using a magnetic field, enabling researchers to pull and rotate a single DNA molecule in a controlled fashion. As the position of the bead changes when the DNA molecule is repaired, researchers are able to observe the repair process in detail.


'/>"/>

Contact: Frank Nuijens
f.w.nuijens@tudelft.nl
31-152-784-259
Delft University of Technology
Source:Eurekalert

Page: 1

Related biology technology :

1. Better business decisions with real-time data
2. LUMEDX Updates Real-Time Patient and Resource Scheduler for Healthcare Systems
3. Enigma Signs Real-Time PCR Licences With Applera
4. Roche Real-Time HIV Test is Faster and Less Labor-Intensive Than Competitors
5. Growing old together: Yeast, worms and people may age by similar mechanisms
6. FDA Approves New Mechanism of Action Labeling for Ranexa(R)
7. Agendia Acquires Rights to the Discovery of a Major Drug Resistance Mechanism in Breast Cancer Potentially Leading to a Herceptin(R) Sensitivity Test
8. Mechanism for the in-vivo transport of siRNA
9. Cleveland Clinic-Led Research Uncovers New Mechanism That Heightens Risk of Heart Disease
10. Gladstone scientists uncover potential mechanism of memory loss in Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2015)... May 05, 2015 Research and Markets ... of the "Clinical Laboratory, Molecular Diagnostics and ... to 2019 - Global Version" report to ... in the area of molecular diagnostics and pharmacogenics ... evolving world market that is moving out of ...
(Date:5/5/2015)... (PRWEB) May 05, 2015 ... Hannifin distributor, announces the launch of http://www.cng.exoticautomation.com ... operators with a convenient way to purchase genuine ... products . , The new website provides ... vehicles with direct access to high performance products ...
(Date:5/4/2015)... May 4, 2015 Many of us ... for certain infants with rare, inherited mutations of ... consequences of their impaired immune responses. ... identified an important role for calcium signaling in ... tuberculosis, the bacterium causing tuberculosis (TB). ...
(Date:5/4/2015)... AVIV, Israel , May 4, 2015  Tikcro ... filed its annual report on Form 20-F for the ... Securities and Exchange Commission ("SEC"). The annual report on ... the development of antibodies in the area of cancer ... with superior qualities of high specificity and binding in ...
Breaking Biology Technology:Global Clinical Laboratory, Molecular Diagnostics and Genomic Testing Services Market Trends and Forecast 2015 to 2019 2Exotic Automation & Supply Launches Ecommerce Website 2Researchers Discover A Novel And Unexpected Role For Calcium In Controlling Inflammation During Chronic Lung Infection 2Researchers Discover A Novel And Unexpected Role For Calcium In Controlling Inflammation During Chronic Lung Infection 3Tikcro Technologies Files Annual Report on Form 20-F for the Year Ended December 31, 2014 2
... Inc., the leading,manufacturer of specialized graphics solutions, confirms ... display controller boards with its,ME/CCL medical LCD displays., ... Express single-slot board with,all-digital, triple-monitor output and the ... supports resolutions from <1MP to,8MP with up to ...
... Oct. 8 CJPS Enterprises, LLC, (http://www.CJPS-Enterprises.com ... Sciences,Pipeline (http://www.MichiganPipeline.com ) is announcing a ... funding for their business, or looking to,invest ... Some of the existing resources available on ...
... heart disease that included numerous medications, trips to the emergency room and ... Intensive Care Unit at an Ohio hospital. Both sides of his heart ... , ... TUCSON, Ariz. (Business Wire EON) October 8, 2008 -- ...
Cached Biology Technology:Totoku Europe Chooses Matrox Xenia(TM) Series to Drive Medical Monitors 2The Michigan Life Sciences Pipeline Announces 'The Funding Place(TM)' and Other Resources to Connect Investors and Startups 2 "Put Down the BBQ Ribs, We've Found You a Donor Heart," Nurse Tells Patient : Ohio Father near Death Gets Second Chance at Life with CardioWest&#8482; temporary Total Artificial Heart 2
(Date:3/24/2015)... PALM BEACH GARDENS, Fla. , March 24, ... of biometric identity management solutions, today announced that ... enabling premium clothing accessory retailer Goorin Bros ... login. The Crossmatch biometrics-based solution secures access to ... customers from the increased risk of data breaches. ...
(Date:3/23/2015)... , March 23, 2015  In the 2014 ... fraud case conviction losses. This figure accounts for a ... according to The Nilson Report, exceeds $11 billion globally. ... tool after a crime has occurred. Investor Mark ... polygraph expert Joe Paolella partnered to administer ...
(Date:3/20/2015)... , Mar. 19, 2015 Research and Markets ... "Hand Geometry - Global Strategic Business Report" report to ... for Hand Geometry in US$ Thousands. The report provides separate ... Japan , Europe , ... , and Rest of World. Annual estimates and ...
Breaking Biology News(10 mins):Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 2Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 4
... grown in popularity, so have complaints of adverse side ... new study, done by chemistry students at Northern Arizona ... of tattoo inks to better understand their potential health ... national meeting of the American Chemical Society, the world's ...
... medical conference here heard that an Australian developed ... common cold virus to control cancer cell growth ... The research was presented to the third International ... 11 March by Newcastle University associate professor, Darren ...
... In a 12-hour, dual-stage surgery known to be performed ... at the University of Alabama at Birmingham on Tuesday ... surgically removing his pancreas to eliminate constant, severe pain ... of Panama City, Fla., remained anesthetized in the operating ...
Cached Biology News:Chemicals in tattoo inks need closer scrutiny 2Chemicals in tattoo inks need closer scrutiny 3Anti cancer virotherapy well tolerated in first human administration, research finds 2Rare surgery performed to remove pancreas, prevent diabetes 2
NPT1 (M-19)...
XA7 B6...
Total Proteins from over 50 different human Alzheimer, Diabetic, Liver Cirrhosis, and Lupus diseased tissues are available....
... With its patented technology, the Lone Wolf ... any Normally Open proportional valve available on ... operation, provides repeatable high-speed performance, and ensures ... , Enhances system control and patient ...
Biology Products: